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Q83R14

- COBT_SHIFL

UniProt

Q83R14 - COBT_SHIFL

Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

    Catalytic activityi

    Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei318 – 3181Proton acceptorUniRule annotation

    GO - Molecular functioni

    1. cobalamin-transporting ATPase activity Source: UniProtKB-HAMAP
    2. nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-KW
    2. nucleoside biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Cobalamin biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00061; UER00516.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
    Short name:
    NN:DBI PRTUniRule annotation
    Alternative name(s):
    N(1)-alpha-phosphoribosyltransferaseUniRule annotation
    Gene namesi
    Name:cobTUniRule annotation
    Ordered Locus Names:SF2059, S2169
    OrganismiShigella flexneri
    Taxonomic identifieri623 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferasePRO_0000167071Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi198214.SF2059.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83R14.
    SMRiQ83R14. Positions 7-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CobT family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2038.
    HOGENOMiHOG000263499.
    KOiK00768.
    OMAiLMIANMA.
    OrthoDBiEOG6HF61K.

    Family and domain databases

    Gene3Di1.10.1610.10. 1 hit.
    HAMAPiMF_00230. CobT.
    InterProiIPR003200. Nict_dMeBzImd_PRibTrfase-like.
    IPR023195. Nict_dMeBzImd_PRibTrfase_N.
    IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
    [Graphical view]
    PfamiPF02277. DBI_PRT. 1 hit.
    [Graphical view]
    SUPFAMiSSF52733. SSF52733. 1 hit.
    TIGRFAMsiTIGR03160. cobT_DBIPRT. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q83R14-1 [UniParc]FASTAAdd to Basket

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    MQIIADLLNT IPAINSAAMS RAQRHVDGLF KPVGSLGKLE ALAIQLAGMP    50
    GVNGIPHVGK KAVLVMCADH GVWEEGVAIS PKEVTAIQAE NMTRGTTGVC 100
    VLAAQAGANV HVIDVGIDTA EPIPGLINMR VARGSGNIAS APAMSRRQAE 150
    KLLLDVICYT RELAKNGVTL FGVGELGMAN TTPAAAIVST ITGRDPEEVV 200
    GIGANLPTDK LANKIDVVRR AITLNQPNPQ DGVDVLAKVG GFDLVGIAGV 250
    MLGAASCGLP VLLDGFLSYA AALAACQMSP AIKPYLIPSH LSAEKGARIA 300
    LSHLGLEPYL NMDMRLGEGS GAALAMSIIE AACAIYNNMG ELAASNIVLP 350
    GNTTSDLNS 359
    Length:359
    Mass (Da):36,880
    Last modified:June 1, 2003 - v1
    Checksum:i337ABE66B7B6443F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN43600.1.
    AE014073 Genomic DNA. Translation: AAP17423.1.
    RefSeqiNP_707893.1. NC_004337.2.
    NP_837614.1. NC_004741.1.

    Genome annotation databases

    EnsemblBacteriaiAAN43600; AAN43600; SF2059.
    AAP17423; AAP17423; S2169.
    GeneIDi1025890.
    1078475.
    KEGGisfl:SF2059.
    sfx:S2169.
    PATRICi18705851. VBIShiFle31049_2404.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN43600.1 .
    AE014073 Genomic DNA. Translation: AAP17423.1 .
    RefSeqi NP_707893.1. NC_004337.2.
    NP_837614.1. NC_004741.1.

    3D structure databases

    ProteinModelPortali Q83R14.
    SMRi Q83R14. Positions 7-350.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198214.SF2059.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN43600 ; AAN43600 ; SF2059 .
    AAP17423 ; AAP17423 ; S2169 .
    GeneIDi 1025890.
    1078475.
    KEGGi sfl:SF2059.
    sfx:S2169.
    PATRICi 18705851. VBIShiFle31049_2404.

    Phylogenomic databases

    eggNOGi COG2038.
    HOGENOMi HOG000263499.
    KOi K00768.
    OMAi LMIANMA.
    OrthoDBi EOG6HF61K.

    Enzyme and pathway databases

    UniPathwayi UPA00061 ; UER00516 .

    Family and domain databases

    Gene3Di 1.10.1610.10. 1 hit.
    HAMAPi MF_00230. CobT.
    InterProi IPR003200. Nict_dMeBzImd_PRibTrfase-like.
    IPR023195. Nict_dMeBzImd_PRibTrfase_N.
    IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
    [Graphical view ]
    Pfami PF02277. DBI_PRT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52733. SSF52733. 1 hit.
    TIGRFAMsi TIGR03160. cobT_DBIPRT. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
      Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
      , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
      Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 301 / Serotype 2a.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700930 / 2457T / Serotype 2a.

    Entry informationi

    Entry nameiCOBT_SHIFL
    AccessioniPrimary (citable) accession number: Q83R14
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3