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Q83R14 (COBT_SHIFL) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Short name=NN:DBI PRT
EC=2.4.2.21
Alternative name(s):
N(1)-alpha-phosphoribosyltransferase
Gene names
Name:cobT
Ordered Locus Names:SF2059, S2169
OrganismShigella flexneri [Complete proteome] [HAMAP]
Taxonomic identifier623 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB) By similarity. HAMAP-Rule MF_00230

Catalytic activity

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate. HAMAP-Rule MF_00230

Pathway

Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2. HAMAP-Rule MF_00230

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00230

Sequence similarities

Belongs to the CobT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase HAMAP-Rule MF_00230
PRO_0000167071

Sites

Active site3181Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83R14 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 337ABE66B7B6443F

FASTA35936,880
        10         20         30         40         50         60 
MQIIADLLNT IPAINSAAMS RAQRHVDGLF KPVGSLGKLE ALAIQLAGMP GVNGIPHVGK 

        70         80         90        100        110        120 
KAVLVMCADH GVWEEGVAIS PKEVTAIQAE NMTRGTTGVC VLAAQAGANV HVIDVGIDTA 

       130        140        150        160        170        180 
EPIPGLINMR VARGSGNIAS APAMSRRQAE KLLLDVICYT RELAKNGVTL FGVGELGMAN 

       190        200        210        220        230        240 
TTPAAAIVST ITGRDPEEVV GIGANLPTDK LANKIDVVRR AITLNQPNPQ DGVDVLAKVG 

       250        260        270        280        290        300 
GFDLVGIAGV MLGAASCGLP VLLDGFLSYA AALAACQMSP AIKPYLIPSH LSAEKGARIA 

       310        320        330        340        350 
LSHLGLEPYL NMDMRLGEGS GAALAMSIIE AACAIYNNMG ELAASNIVLP GNTTSDLNS 

« Hide

References

[1]"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. expand/collapse author list , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 301 / Serotype 2a.
[2]"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T."
Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.
Infect. Immun. 71:2775-2786(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 700930 / 2457T / Serotype 2a.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005674 Genomic DNA. Translation: AAN43600.1.
AE014073 Genomic DNA. Translation: AAP17423.1.
RefSeqNP_707893.1. NC_004337.2.
NP_837614.1. NC_004741.1.

3D structure databases

ProteinModelPortalQ83R14.
SMRQ83R14. Positions 7-350.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198214.SF2059.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN43600; AAN43600; SF2059.
AAP17423; AAP17423; S2169.
GeneID1025890.
1078475.
KEGGsfl:SF2059.
sfx:S2169.
PATRIC18705851. VBIShiFle31049_2404.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2038.
HOGENOMHOG000263499.
KOK00768.
OMALMIANMA.
OrthoDBEOG6HF61K.

Enzyme and pathway databases

UniPathwayUPA00061; UER00516.

Family and domain databases

Gene3D1.10.1610.10. 1 hit.
HAMAPMF_00230. CobT.
InterProIPR003200. Nict_dMeBzImd_PRibTrfase-like.
IPR023195. Nict_dMeBzImd_PRibTrfase_N.
IPR017846. Nict_dMeBzImd_PRibTrfase_pro.
[Graphical view]
PfamPF02277. DBI_PRT. 1 hit.
[Graphical view]
SUPFAMSSF52733. SSF52733. 1 hit.
TIGRFAMsTIGR03160. cobT_DBIPRT. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCOBT_SHIFL
AccessionPrimary (citable) accession number: Q83R14
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways