Q83QM8 (TALA_SHIFL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transaldolase A
EC=2.2.1.2

Gene names

Name:	talA
Ordered Locus Names:	SF2506, S2657

Organism

Shigella flexneri [Complete proteome] [HAMAP]

Taxonomic identifier

623 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway By similarity. HAMAP MF_00492
Catalytic activity	Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate. HAMAP MF_00492
Pathway	Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3. HAMAP MF_00492
Subcellular location	Cytoplasm By similarity HAMAP MF_00492.
Sequence similarities	Belongs to the transaldolase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Pentose shunt
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	pentose-phosphate shunt Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Transaldolase A HAMAP MF_00492		PRO_0000173616
Sites
	Active site	131	1	By similarity
Experimental info
	Sequence conflict	33	1	A → T in AAP17825. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q83QM8 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 2C07428EA4F75CF1	FASTA	316	35,652
	10 20 30 40 50 60 MNELDGIKQF TTVVADSCDI ESIRHYHPQD ATANPSLLLK AAGLSQYEHL IDDAIAWGKK 70 80 90 100 110 120 NGKTQEQQVV AACDKLAVNF GAEILKIVPG CVSTEVDARL SFDKEKSIEK ARHLVDLYQQ 130 140 150 160 170 180 QGVEKSRILI KLASTWEGIR AAEELEKEGI NCNLTLLFSF TQARACAEAG VFLISPFVGR 190 200 210 220 230 240 IYDWYQARKP MDPYVVEEDP GVKSVRNIYD YYKQHHYETI VMGASFRRTE QILALTGCDR 250 260 270 280 290 300 LTIAPNLLKE LQEKVSPVVR KLIPPSQTFP RPAPMSEAEF RWEHNQDAMA VEKLSEGIRL 310 FAVDQRKLED LLAAKL

References

[1]

"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157." Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J. Nucleic Acids Res. 30:4432-4441(2002) [PubMed: 12384590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 301 / Serotype 2a.

[2]

"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T." Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R. Infect. Immun. 71:2775-2786(2003) [PubMed: 12704152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700930 / 2457T / Serotype 2a.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005674 Genomic DNA. Translation: AAN44010.1. AE014073 Genomic DNA. Translation: AAP17825.1.
RefSeq	NP_708303.1. NC_004337.2. NP_838015.1. NC_004741.1.
3D structure databases
ProteinModelPortal	Q83QM8.
SMR	Q83QM8. Positions 2-313.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBESCT00000085322; EBESCP00000082144; EBESCG00000084368. EBESCT00000093464; EBESCP00000090100; EBESCG00000092508.
GeneID	1026828. 1078928.
GenomeReviews	Gene locus SF2506 in contig AE005674_GR. Gene locus S2657 in contig AE014073_GR.
KEGG	sfl:SF2506. sfx:S2657.
PATRIC	18706932. VBIShiFle31049_2935.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000009451.
HOGENOM	HBG286747.
OMA	NREKSIE.
ProtClustDB	PRK12346.
Enzyme and pathway databases
BioCyc	SFLE198214:AAN44010.1-MONOMER.
Family and domain databases
HAMAP	MF_00492. Transaldolase_1. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001585. Transaldolase. IPR004730. Transaldolase_1. IPR018225. Transaldolase_AS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00616.
PANTHER	PTHR10683. Transaldolase. 1 hit.
Pfam	PF00923. Transaldolase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00874. TalAB. 1 hit.
PROSITE	PS01054. TRANSALDOLASE_1. False negative. PS00958. TRANSALDOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TALA_SHIFL

Accession

Primary (citable) accession number: Q83QM8
Secondary accession number(s): Q7UC15

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program