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Q83QB7 (Q83QB7_SHIFL) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Diaminopimelate decarboxylase HAMAP-Rule MF_02120

Short name=DAP decarboxylase HAMAP-Rule MF_02120
Short name=DAPDC HAMAP-Rule MF_02120
EC=4.1.1.20 HAMAP-Rule MF_02120
Gene names
Name:lysA HAMAP-Rule MF_02120 EMBL AAN44334.1
Ordered Locus Names:S3046 EMBL AAP18160.1, SF2848 EMBL AAN44334.1
OrganismShigella flexneri [Complete proteome] [HAMAP]
Taxonomic identifier623 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella

Protein attributes

Sequence length420 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine By similarity. HAMAP-Rule MF_02120

Catalytic activity

Meso-2,6-diaminoheptanedioate = L-lysine + CO2. RuleBase RU003738 HAMAP-Rule MF_02120

Cofactor

Pyridoxal phosphate By similarity. SAAS SAAS009006 RuleBase RU003738 HAMAP-Rule MF_02120

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; L-lysine from DL-2,6-diaminopimelate: step 1/1. RuleBase RU003738 HAMAP-Rule MF_02120

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_02120

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily. HAMAP-Rule MF_02120

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region268 – 2714Pyridoxal phosphate binding By similarity HAMAP-Rule MF_02120

Sites

Binding site2271Pyridoxal phosphate; via amide nitrogen By similarity HAMAP-Rule MF_02120
Binding site2711Substrate By similarity HAMAP-Rule MF_02120
Binding site3071Substrate By similarity HAMAP-Rule MF_02120
Binding site3111Substrate By similarity HAMAP-Rule MF_02120
Binding site3431Substrate By similarity HAMAP-Rule MF_02120
Binding site3781Pyridoxal phosphate By similarity HAMAP-Rule MF_02120
Binding site3781Substrate By similarity HAMAP-Rule MF_02120

Amino acid modifications

Modified residue541N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_02120

Sequences

Sequence LengthMass (Da)Tools
Q83QB7 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 5CF953BC40B338F9

FASTA42046,175
        10         20         30         40         50         60 
MPHSLFSTDT DLTAENLLRL PAEFGCPVWV YDAQIIRRQI AALKQFEVVR FAQKACSNIH 

        70         80         90        100        110        120 
ILRLMREQGV KVDSVSLGEI ERALAAGYNP QTHPDDIVFT ADVIDQATLE RVSELQIPVN 

       130        140        150        160        170        180 
AGSVDTLDQL GQVSPGHRVW LRVNPGFGHG HSQKTNTGGE NSKHGIWYTD LPAALDVIQR 

       190        200        210        220        230        240 
HHLQLVGIHM HIGSGVDYAH LEQVCGAMVR QVIEFGQDLQ AISAGGGLSI PYQQGEEAVD 

       250        260        270        280        290        300 
TEHYYGLWNA AREQIARHLG HPVKLEIEPG RFLVAQSGVL ITQVRSVKQM GSRHFVLVDA 

       310        320        330        340        350        360 
GFNDLMRPAM YGSYHHISAL AADGRSLEHA PTVETVVAGP LCESGDVFTQ QEGGNVETRA 

       370        380        390        400        410        420 
LPEVKAGDYL VLHDTGAYGA SMSSNYNSRP LLPEVLFDNG QARLIRRRQT IEELLALELL 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. expand/collapse author list , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 301 EMBL AAN44334.1 and 301 / Serotype 2a.
[2]"Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T."
Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G.III., Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.
Infect. Immun. 71:2775-2786(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 2457T EMBL AAP18160.1 and ATCC 700930 / 2457T / Serotype 2a.
[3]Jin Q., Shen Y., Wang J.H., Liu H., Yang J., Yang F., Zhang X.B., Zhang J.Y., Yang G.W., Wu H.T., Dong J., Sun L.L., Xue Y., Zhao A.L., Gao Y.S., Zhu J.P., Chen S.X., Yao Z.J. expand/collapse author list , Wang Y., Lu W.C., Qiang B.Q., Wen Y.M., Hou Y.D.
Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 301 EMBL AAN44334.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005674 Genomic DNA. Translation: AAN44334.1.
AE014073 Genomic DNA. Translation: AAP18160.1.
RefSeqNP_708627.1. NC_004337.2.
NP_838350.1. NC_004741.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING198214.SF2848.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN44334; AAN44334; SF2848.
AAP18160; AAP18160; S3046.
GeneID1025821.
1079313.
KEGGsfl:SF2848.
sfx:S3046.
PATRIC18707782. VBIShiFle31049_3343.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000045070.
KOK01586.
OMACETDTFA.
OrthoDBEOG6Z9B18.
ProtClustDBPRK11165.

Enzyme and pathway databases

UniPathwayUPA00034; UER00027.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_02120. LysA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002986. DAP_deCOOHase_LysA.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PRINTSPR01181. DAPDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR01048. lysA. 1 hit.
PROSITEPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ83QB7_SHIFL
AccessionPrimary (citable) accession number: Q83QB7
Secondary accession number(s): Q7C059
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)