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Protein

Membrane-bound lytic murein transglycosylase C

Gene

mltC

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.UniRule annotation

Catalytic activityi

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Cell wall biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-bound lytic murein transglycosylase CUniRule annotation (EC:4.2.2.n1UniRule annotation)
Alternative name(s):
Murein lyase CUniRule annotation
Gene namesi
Name:mltCUniRule annotation
Ordered Locus Names:SF2960, S3163
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

  • Cell outer membrane UniRule annotation; Lipid-anchor UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16UniRule annotationAdd BLAST16
ChainiPRO_000003279817 – 359Membrane-bound lytic murein transglycosylase CAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi17N-palmitoyl cysteineUniRule annotation1
Lipidationi17S-diacylglycerol cysteineUniRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ83Q83.

Interactioni

Protein-protein interaction databases

STRINGi198214.SF2960.

Structurei

3D structure databases

ProteinModelPortaliQ83Q83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transglycosylase Slt family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4106S48. Bacteria.
COG0741. LUCA.
HOGENOMiHOG000283572.
KOiK08306.
OMAiAIMQIES.

Family and domain databases

HAMAPiMF_01616. MltC. 1 hit.
InterProiIPR023346. Lysozyme-like_dom.
IPR023664. Murein_transglycosylaseC.
IPR024570. Murein_transglycosylaseC_N.
IPR000189. Transglyc_AS.
IPR008258. Transglycosylase_SLT_dom_1.
[Graphical view]
PfamiPF11873. DUF3393. 1 hit.
PF01464. SLT. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00922. TRANSGLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q83Q83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKYLALALI APLLISCSTT KKGDTYNEAW VKDTNGFDIL MGQFAHNIEN
60 70 80 90 100
IWGFKEVVIA GPKDYVKYTD QYQTRSHINF DDGTITIETI AGTEPAAHLR
110 120 130 140 150
RAIIKTLLMG DDPSSVDLYS DVDDITISKE PFLYGQVVDN TGQPIRWEGR
160 170 180 190 200
ASNFADYLLK NRLKSRSNGL RIIYSVTINM VPNHLDKRAH KYLGMVRQAS
210 220 230 240 250
RKYGVDESLI LAIMQTESSF NPYAVSRSDA LGLMQVVQNT AGKDVFRSQG
260 270 280 290 300
KSGTPSRSFL FDPASNIDTG TAYLAMLNNV YLGGIDNPTS RRYAVITAYN
310 320 330 340 350
GGAGSVLRVF SNDKIQAANI INTMTPGDVY QTLTTRHPSA ESRRYLYKVN

TAQKSYRRR
Length:359
Mass (Da):40,089
Last modified:July 19, 2005 - v2
Checksum:i622F09CC9C41909C
GO

Sequence cautioni

The sequence AAN44441 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP18265 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN44441.1. Different initiation.
AE014073 Genomic DNA. Translation: AAP18265.1. Different initiation.
RefSeqiNP_708734.1. NC_004337.2.
WP_005064048.1. NZ_LVJC01000036.1.

Genome annotation databases

EnsemblBacteriaiAAN44441; AAN44441; SF2960.
AAP18265; AAP18265; S3163.
GeneIDi1026499.
KEGGisfl:SF2960.
sft:NCTC1_03251.
sfx:S3163.
PATRICi18708027. VBIShiFle31049_3463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN44441.1. Different initiation.
AE014073 Genomic DNA. Translation: AAP18265.1. Different initiation.
RefSeqiNP_708734.1. NC_004337.2.
WP_005064048.1. NZ_LVJC01000036.1.

3D structure databases

ProteinModelPortaliQ83Q83.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF2960.

Proteomic databases

PaxDbiQ83Q83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN44441; AAN44441; SF2960.
AAP18265; AAP18265; S3163.
GeneIDi1026499.
KEGGisfl:SF2960.
sft:NCTC1_03251.
sfx:S3163.
PATRICi18708027. VBIShiFle31049_3463.

Phylogenomic databases

eggNOGiENOG4106S48. Bacteria.
COG0741. LUCA.
HOGENOMiHOG000283572.
KOiK08306.
OMAiAIMQIES.

Family and domain databases

HAMAPiMF_01616. MltC. 1 hit.
InterProiIPR023346. Lysozyme-like_dom.
IPR023664. Murein_transglycosylaseC.
IPR024570. Murein_transglycosylaseC_N.
IPR000189. Transglyc_AS.
IPR008258. Transglycosylase_SLT_dom_1.
[Graphical view]
PfamiPF11873. DUF3393. 1 hit.
PF01464. SLT. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00922. TRANSGLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMLTC_SHIFL
AccessioniPrimary (citable) accession number: Q83Q83
Secondary accession number(s): Q7C017
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 19, 2005
Last modified: November 30, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.