Reviewed,
UniProtKB/Swiss-Prot Q83PP7 (LLDD_SHIFL)
Last modified
November 25, 2008.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: L-lactate dehydrogenase [cytochrome] EC=1.1.2.3 | ||||
| Gene names |
| ||||
| Organism | Shigella flexneri [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 623 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Shigella |
Protein attributes
| Sequence length | 396 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+). |
| Cofactor | FMN By similarity. |
| Sequence similarities | Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. Contains 1 FMN hydroxy acid dehydrogenase domain. |
Ontologies
Keywords | |
|---|---|
| Ligand | FMN Flavoprotein |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | FMN binding Inferred from electronic annotation. Source: InterPro L-lactate dehydrogenase (cytochrome) activityInferred from electronic annotation. Source: HAMAP electron carrier activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 396 | 396 | L-lactate dehydrogenase [cytochrome] | PRO_0000206350 | |||||
Regions | |||||||||
| Domain | 1 – 380 | 380 | FMN hydroxy acid dehydrogenase | ||||||
| Nucleotide binding | 306 – 330 | 25 | FMN By similarity | ||||||
Sites | |||||||||
| Active site | 275 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 24 | 1 | Substrate Potential | ||||||
| Binding site | 106 | 1 | FMN By similarity | ||||||
| Binding site | 127 | 1 | FMN By similarity | ||||||
| Binding site | 129 | 1 | Substrate By similarity | ||||||
| Binding site | 155 | 1 | FMN By similarity | ||||||
| Binding site | 164 | 1 | Substrate By similarity | ||||||
| Binding site | 251 | 1 | FMN By similarity | ||||||
| Binding site | 278 | 1 | Substrate Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157." Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y. Yu J.Nucleic Acids Res. 30:4432-4441(2002) [PubMed: 12384590] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 301 / Serotype 2a. |
| [2] | "Complete genome sequence and comparative genomics of Shigella flexneri serotype 2a strain 2457T." Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G., Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T., Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R. Infect. Immun. 71:2775-2786(2003) [PubMed: 12704152] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 700930 / 2457T / Serotype 2a. |
Cross-references
Sequence databases | |
|---|---|
| AE005674 Genomic DNA. Translation: AAN45091.1. AE014073 Genomic DNA. Translation: AAP19101.1. | |
| RefSeq | NP_709384.1. NP_839290.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GOX based on UniProtKB P05414. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1026893. 1078229. |
| GenomeReviews | Gene locus S4124 in contig AE014073_GR. Gene locus SF3644 in contig AE005674_GR. |
| KEGG | sfl:SF3644. sfx:S4124. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q83PP7. |
Enzyme and pathway databases | |
| BioCyc | SFLE198214:AAN45091.1-MON. |
Family and domain databases | |
| HAMAP | MF_01559. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR012133. Alpha_OHA_DHase_FMN. IPR008259. FMN_hydac_DHase_AS. IPR000262. FMN_OHA_DHase. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| Pfam | PF01070. FMN_dh. 1 hit. [Graphical view] |
| PIRSF | PIRSF000138. Al-hdrx_acd_dh. 1 hit. |
| PROSITE | PS00557. FMN_HYDROXY_ACID_DH_1. 1 hit. PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LLDD_SHIFL | ||||||||
| Accession | Primary (citable) accession number: Q83PP7 Secondary accession number(s): Q7BZ23 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


