Q83NS5 (GLMM_TROW8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	TW155

Organism

Tropheryma whipplei (strain TW08/27) (Whipple's bacillus) [Complete proteome] [HAMAP]

Taxonomic identifier

218496 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › unclassified Micrococcineae › Tropheryma › Tropheryma whipplei

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP-Rule MF_01554
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP-Rule MF_01554
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_01554
Post-translational modification	Activated by phosphorylation By similarity. HAMAP-Rule MF_01554
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP phosphoglucosamine mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 453	453	Phosphoglucosamine mutase HAMAP-Rule MF_01554		PRO_0000147994
Sites
	Active site	110	1	Phosphoserine intermediate By similarity
	Metal binding	110	1	Magnesium; via phosphate group By similarity
	Metal binding	247	1	Magnesium By similarity
	Metal binding	249	1	Magnesium By similarity
	Metal binding	251	1	Magnesium By similarity
Amino acid modifications
	Modified residue	110	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q83NS5 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 220D71FD59A240BC	FASTA	453	48,455
	10 20 30 40 50 60 MARLFGTDGI RALANGDLLT PELAMAVARA AAVVFTHGRV AKRRQVLGKR PVAIVARDPR 70 80 90 100 110 120 ISGDFLVAAI SAGLASSGVD VLDAGVIPTP AVAFLVKNAN ADFGFMISAS HNPGYDNGVK 130 140 150 160 170 180 IFAHGGVKLP DVVEDRIEYF LDKQKLSPIG SKVGRITRFV DAEDRYQMHL LSTLFTRIDG 190 200 210 220 230 240 VKVVIDCANG AASGVSPDVF KSAGAAVKVI CADPNGVNIN DGVGSAYPER LRAEVIRNSA 250 260 270 280 290 300 TLGLAFDGDA DRCIAVDSNG NTVDGDQIMA ILARSMQQRG TLRNKTLVTT IMSNIGLDRA 310 320 330 340 350 360 MKKLGINLKR TQVGDRYVIE AMTQGGFNIG GEQSGHIILS DYSTAGDGIL AGLHLCAEII 370 380 390 400 410 420 RTGKSLTDLA SIMEIVPQVT ANIETDDPTT LLNNKKIRHE ISRIEKSLKG RVVIRPSGTE 430 440 450 PLIRIMVEDL NPEKAERACS HLADFFKQEI QKS

References

[1]

"Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei." Bentley S.D., Maiwald M., Murphy L.D., Pallen M.J., Yeats C.A., Dover L.G., Norbertczak H.T., Besra G.S., Quail M.A., Harris D.E., von Herbay A., Goble A., Rutter S., Squares R., Squares S., Barrell B.G., Parkhill J., Relman D.A. Lancet 361:637-644(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW08/27.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX251410 Genomic DNA. Translation: CAD66835.1.
RefSeq	NP_789098.1. NC_004551.1.
3D structure databases
ProteinModelPortal	Q83NS5.
ModBase	Search...
Protein-protein interaction databases
STRING	218496.TW155.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAD66835; CAD66835; TW155.
GeneID	1064450.
KEGG	tws:TW155.
PATRIC	23998701. VBITroWhi42739_0195.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
HOGENOM	HOG000268678.
KO	K03431.
OMA	TLMSNMS.
ProtClustDB	PRK14318.
Family and domain databases
Gene3D	3.40.120.10. 3 hits.
HAMAP	MF_01554_B. GlmM_B.
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 2 hits.
TIGRFAMs	TIGR01455. glmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_TROW8

Accession

Primary (citable) accession number: Q83NS5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 20, 2005
Last sequence update:	June 1, 2003
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program