Q83NN3 (EFTS_TROW8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Elongation factor Ts
Short name=EF-Ts

Gene names

Name:	tsf
Ordered Locus Names:	TW319

Organism

Tropheryma whipplei (strain TW08/27) (Whipple's bacillus) [Complete proteome] [HAMAP]

Taxonomic identifier

218496 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. HAMAP MF_00050
Subcellular location	Cytoplasm HAMAP MF_00050.
Sequence similarities	Belongs to the EF-Ts family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Elongation factor Ts HAMAP MF_00050		PRO_0000161226
Regions
	Region	80 – 83	4	Involved in Mg(2+) ion dislocation from EF-Tu By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q83NN3 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 2A83FCB1432E432C	FASTA	273	30,093
	10 20 30 40 50 60 MVDISMADVR LLRERLGVGV MDSRNALIEA GGDIERAVEI LRLKGLKSAE KREGRSVSEG 70 80 90 100 110 120 LVVSRQFATH AVLAELCCET DFVAKSDRFL ALSERVADLV SDADSLETAL RVRCDEGSVA 130 140 150 160 170 180 DLIALEAAVL GENVALRRFA RVEGSRFSVY MHRTSSDLPP QVGVILAYEG HDDATARFIA 190 200 210 220 230 240 QHIAFAAPEY LSVGDIPQGI LQRERDLLTE ISRGEGKPEE VLPQIVEGRL VKLYKQNVLL 250 260 270 EQDYVRDNKV TISKVLEATG LRVISFARFR VGT

References

[1]

"Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei." Bentley S.D., Maiwald M., Murphy L.D., Pallen M.J., Yeats C.A., Dover L.G., Norbertczak H.T., Besra G.S., Quail M.A., Harris D.E., von Herbay A., Goble A., Rutter S., Squares R., Squares S., Barrell B.G., Parkhill J., Relman D.A. Lancet 361:637-644(2003) [PubMed: 12606174] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW08/27.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX251411 Genomic DNA. Translation: CAD66992.1.
RefSeq	NP_789254.1. NC_004551.1.
3D structure databases
ProteinModelPortal	Q83NN3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q83NN3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1064607.
GenomeReviews	Gene locus TW319 in contig BX072543_GR.
KEGG	tws:TW319.
PATRIC	23999095. VBITroWhi42739_0383.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0264.
HOGENOM	HBG713289.
OMA	YLHGTRI.
PhylomeDB	Q83NN3.
ProtClustDB	PRK09377.
Enzyme and pathway databases
BioCyc	TWHI218496:TW0299-MONOMER.
Family and domain databases
HAMAP	MF_00050. EF_Ts. [Tree]
InterPro	IPR001816. Transl_elong_EFTs/EF1B. IPR014039. Transl_elong_EFTs/EF1B_dimer. IPR018101. Transl_elong_Ts_CS. IPR009060. UBA-like. IPR000449. UBA/transl_elong_EF1B_N. [Graphical view]
Gene3D	G3DSA:3.30.479.20. Transl_elong_EFTs/EF1B_dimer. 3 hits.
KO	K02357.
PANTHER	PTHR11741. Transl_elong_EFTs/EF1B. 1 hit.
Pfam	PF00889. EF_TS. 1 hit. PF00627. UBA. 1 hit. [Graphical view]
SUPFAM	SSF54713. EF_TS. 1 hit. SSF46934. UBA_like. 1 hit.
TIGRFAMs	TIGR00116. Tsf. 1 hit.
PROSITE	PS01126. EF_TS_1. False negative. PS01127. EF_TS_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFTS_TROW8

Accession

Primary (citable) accession number: Q83NN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program