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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi102 – 109ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:TWT_130
OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
Taxonomic identifieri203267 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesTropheryma
Proteomesi
  • UP000002200 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation
  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003184821 – 847Protein translocase subunit SecAAdd BLAST847

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi203267.TWT130

Structurei

3D structure databases

ProteinModelPortaliQ83N29
SMRiQ83N29
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6 Bacteria
COG0653 LUCA
KOiK03070
OMAiFEYDEVM
OrthoDBiPOG091H01RS

Family and domain databases

HAMAPiMF_01382 SecA, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000185 SecA
IPR020937 SecA_CS
IPR011115 SecA_DEAD
IPR014018 SecA_motor_DEAD
IPR011130 SecA_preprotein_X-link_dom
IPR011116 SecA_Wing/Scaffold
IPR036266 SecA_Wing/Scaffold_sf
IPR036670 SecA_X-link_sf
PANTHERiPTHR30612 PTHR30612, 2 hits
PfamiView protein in Pfam
PF07517 SecA_DEAD, 1 hit
PF01043 SecA_PP_bind, 1 hit
PF07516 SecA_SW, 1 hit
PRINTSiPR00906 SECA
SMARTiView protein in SMART
SM00957 SecA_DEAD, 1 hit
SM00958 SecA_PP_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
SSF81767 SSF81767, 1 hit
SSF81886 SSF81886, 1 hit
TIGRFAMsiTIGR00963 secA, 1 hit
PROSITEiView protein in PROSITE
PS01312 SECA, 1 hit
PS51196 SECA_MOTOR_DEAD, 1 hit

Sequencei

Sequence statusi: Complete.

Q83N29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKLLERIL RAGEGRTLKR LRNIAHTVNA IEDEYKGCTD GELRTFAFDL
60 70 80 90 100
KVRHQNGESL DSILPEAFAM VREASSRTLG LRHFDVQIMG GAALHMGYIA
110 120 130 140 150
EMFTGEGKTL VATLPAFLNS LSGNGVHIVT VNDYLAGYHS QQMGRVYKVL
160 170 180 190 200
GLETGVILAD QDPSTRAQQY RADITYGTNN EFGFDYLRDN MAWSCAERVQ
210 220 230 240 250
RGHNFVILDE VDSILIDEAR TPLIISGSSS GEVSRWFVEF AGIARALTAG
260 270 280 290 300
EDYDVDERKH TVGVLEPGIA KVEDLLGISN LYESVNTPLI SFLNNSIKAK
310 320 330 340 350
ELFKRDRDYV VLDGEVMIVD EHTGRILSGR RYNEGLHQAI EAKEGVEIKA
360 370 380 390 400
ENQTLATVTL QNYFRLYKKI SGMTGTAVTE ASEFMSTYKL PVVSIPTNKP
410 420 430 440 450
NIRKDHPDVV YKNEQIKFEN LADHVRECYT RGQPVLIGTT SVEKSEYVSK
460 470 480 490 500
LLSKRGVRHE VLNAKNHAKE ARIVAEAGRL RAVTVATNMA GRGTDIILGG
510 520 530 540 550
NPEVLTAVEL RRKGLDPSKD PERYEQAWSS AFPKLHRRTR EEAEKVIEAG
560 570 580 590 600
GLMVIGTERH ESRRIDNQLR GRSGRQGDPG ESRFYLSLTD DLMRKFNPGA
610 620 630 640 650
ASALAARVPD DTAIESKLVS RAIRSAQAQV ESLNAETRKN VLKYDDVLNR
660 670 680 690 700
QRAAIYTDRS RILEGGDIAD RVQAFLSDAI EEIINSHAVT AWDFDALWAD
710 720 730 740 750
LKTIYPVGIS IEELTDEAGG MGRITPDFVM REILSDAKFA YEKRESEIGP
760 770 780 790 800
ESMRDLERKV VLSVIDRCWR DHLYEMEYLK EGIGLRAMAQ RDPLVEYQKE
810 820 830 840
GFDMFEAMMG RIREESIGYL FNIDAQVSSN SPSDARNRPI EHDDNAV
Length:847
Mass (Da):94,928
Last modified:June 1, 2003 - v1
Checksum:iE9DBF5EE8722D41B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014184 Genomic DNA Translation: AAO44227.1
RefSeqiWP_011096100.1, NC_004572.3

Genome annotation databases

EnsemblBacteriaiAAO44227; AAO44227; TWT_130
GeneIDi29578106
KEGGitwh:TWT_130

Similar proteinsi

Entry informationi

Entry nameiSECA_TROWT
AccessioniPrimary (citable) accession number: Q83N29
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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