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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi102 – 109ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:TWT_130
OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
Taxonomic identifieri203267 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesTropheryma
Proteomesi
  • UP000002200 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003184821 – 847Protein translocase subunit SecAAdd BLAST847

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi203267.TWT130.

Structurei

3D structure databases

ProteinModelPortaliQ83N29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
KOiK03070.
OMAiIATERHE.
OrthoDBiPOG091H01RS.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83N29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVKLLERIL RAGEGRTLKR LRNIAHTVNA IEDEYKGCTD GELRTFAFDL
60 70 80 90 100
KVRHQNGESL DSILPEAFAM VREASSRTLG LRHFDVQIMG GAALHMGYIA
110 120 130 140 150
EMFTGEGKTL VATLPAFLNS LSGNGVHIVT VNDYLAGYHS QQMGRVYKVL
160 170 180 190 200
GLETGVILAD QDPSTRAQQY RADITYGTNN EFGFDYLRDN MAWSCAERVQ
210 220 230 240 250
RGHNFVILDE VDSILIDEAR TPLIISGSSS GEVSRWFVEF AGIARALTAG
260 270 280 290 300
EDYDVDERKH TVGVLEPGIA KVEDLLGISN LYESVNTPLI SFLNNSIKAK
310 320 330 340 350
ELFKRDRDYV VLDGEVMIVD EHTGRILSGR RYNEGLHQAI EAKEGVEIKA
360 370 380 390 400
ENQTLATVTL QNYFRLYKKI SGMTGTAVTE ASEFMSTYKL PVVSIPTNKP
410 420 430 440 450
NIRKDHPDVV YKNEQIKFEN LADHVRECYT RGQPVLIGTT SVEKSEYVSK
460 470 480 490 500
LLSKRGVRHE VLNAKNHAKE ARIVAEAGRL RAVTVATNMA GRGTDIILGG
510 520 530 540 550
NPEVLTAVEL RRKGLDPSKD PERYEQAWSS AFPKLHRRTR EEAEKVIEAG
560 570 580 590 600
GLMVIGTERH ESRRIDNQLR GRSGRQGDPG ESRFYLSLTD DLMRKFNPGA
610 620 630 640 650
ASALAARVPD DTAIESKLVS RAIRSAQAQV ESLNAETRKN VLKYDDVLNR
660 670 680 690 700
QRAAIYTDRS RILEGGDIAD RVQAFLSDAI EEIINSHAVT AWDFDALWAD
710 720 730 740 750
LKTIYPVGIS IEELTDEAGG MGRITPDFVM REILSDAKFA YEKRESEIGP
760 770 780 790 800
ESMRDLERKV VLSVIDRCWR DHLYEMEYLK EGIGLRAMAQ RDPLVEYQKE
810 820 830 840
GFDMFEAMMG RIREESIGYL FNIDAQVSSN SPSDARNRPI EHDDNAV
Length:847
Mass (Da):94,928
Last modified:June 1, 2003 - v1
Checksum:iE9DBF5EE8722D41B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014184 Genomic DNA. Translation: AAO44227.1.
RefSeqiWP_011096100.1. NC_004572.3.

Genome annotation databases

EnsemblBacteriaiAAO44227; AAO44227; TWT_130.
KEGGitwh:TWT_130.
PATRICi23996539. VBITroWhi72342_0161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014184 Genomic DNA. Translation: AAO44227.1.
RefSeqiWP_011096100.1. NC_004572.3.

3D structure databases

ProteinModelPortaliQ83N29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi203267.TWT130.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO44227; AAO44227; TWT_130.
KEGGitwh:TWT_130.
PATRICi23996539. VBITroWhi72342_0161.

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
KOiK03070.
OMAiIATERHE.
OrthoDBiPOG091H01RS.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSECA_TROWT
AccessioniPrimary (citable) accession number: Q83N29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.