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Q83M39

- AES_SHIFL

UniProt

Q83M39 - AES_SHIFL

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Protein
Acetyl esterase
Gene
aes, SF0421, S0428
Organism
Shigella flexneri
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei165 – 1651 By similarity
Active sitei262 – 2621 By similarity
Active sitei292 – 2921 By similarity

GO - Molecular functioni

  1. carboxylic ester hydrolase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl esterase (EC:3.1.1.-)
Gene namesi
Name:aes
Ordered Locus Names:SF0421, S0428
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Acetyl esteraseUniRule annotation
PRO_0000239713Add
BLAST

Interactioni

Subunit structurei

Homodimer. Interacts with MalT and MelA By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi198214.SF0421.

Structurei

3D structure databases

ProteinModelPortaliQ83M39.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi91 – 933Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0657.
HOGENOMiHOG000117644.
KOiK01066.
OrthoDBiEOG6SZ1F1.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
HAMAPiMF_01958. Acetyl_esterase.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR023508. Acetyl_esterase.
IPR002168. Lipase_GDXG_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01173. LIPASE_GDXG_HIS. 1 hit.
PS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83M39-1 [UniParc]FASTAAdd to Basket

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MKPENKLPVL DLISAEMKTV VNTLQPDLPS WPATGTIAEQ RQYYTLERRF    50
WNAGAPEMAT RAYMVPTKYG QVETRLFCPQ PDSPATLFYL HGGGFILGNL 100
DTHDRIMRLL ASYSQCTVIG INYTLSPEAR FPQAIEEIVA ACCYFHQQAE 150
DYQINMSRIG FAGDSAGAML ALASALWLRD KQIDCGKIAG VLLWYGLYGL 200
RDSVTRRLLG GVWDGLTQQD LQMYEEAYLS NDADRESPYY CLFNNDLTRE 250
VPPCFIAGAE FDPLLDDSRL LYQTLAAHQQ PCEFKLYPGT LHAFLHYSRM 300
MKTADEALRD GAQFFTAQL 319
Length:319
Mass (Da):36,037
Last modified:June 13, 2006 - v2
Checksum:iA61E91C47CEB35D6
GO

Sequence cautioni

The sequence AAN42076.1 differs from that shown. Reason: Erroneous termination at position 273. Translated as Gln.
The sequence AAP15953.1 differs from that shown. Reason: Erroneous termination at position 273. Translated as Gln.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN42076.1. Sequence problems.
AE014073 Genomic DNA. Translation: AAP15953.1. Sequence problems.
RefSeqiNP_706369.1. NC_004337.2.
NP_836147.1. NC_004741.1.

Genome annotation databases

EnsemblBacteriaiAAN42076; AAN42076; SF0421.
AAP15953; AAP15953; S0428.
GeneIDi1027722.
1076865.
KEGGisfl:SF0421.
sfx:S0428.
PATRICi18701879. VBIShiFle31049_0472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005674 Genomic DNA. Translation: AAN42076.1 . Sequence problems.
AE014073 Genomic DNA. Translation: AAP15953.1 . Sequence problems.
RefSeqi NP_706369.1. NC_004337.2.
NP_836147.1. NC_004741.1.

3D structure databases

ProteinModelPortali Q83M39.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 198214.SF0421.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN42076 ; AAN42076 ; SF0421 .
AAP15953 ; AAP15953 ; S0428 .
GeneIDi 1027722.
1076865.
KEGGi sfl:SF0421.
sfx:S0428.
PATRICi 18701879. VBIShiFle31049_0472.

Phylogenomic databases

eggNOGi COG0657.
HOGENOMi HOG000117644.
KOi K01066.
OrthoDBi EOG6SZ1F1.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
HAMAPi MF_01958. Acetyl_esterase.
InterProi IPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR023508. Acetyl_esterase.
IPR002168. Lipase_GDXG_AS.
[Graphical view ]
Pfami PF07859. Abhydrolase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS01173. LIPASE_GDXG_HIS. 1 hit.
PS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
    Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
    , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
    Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 301 / Serotype 2a.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700930 / 2457T / Serotype 2a.

Entry informationi

Entry nameiAES_SHIFL
AccessioniPrimary (citable) accession number: Q83M39
Secondary accession number(s): Q7C2W8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: June 11, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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