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Protein

Peptide methionine sulfoxide reductase MsrB

Gene

msrB

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46ZincPROSITE-ProRule annotation1
Metal bindingi49ZincPROSITE-ProRule annotation1
Metal bindingi95ZincPROSITE-ProRule annotation1
Metal bindingi98ZincPROSITE-ProRule annotation1
Active sitei118NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase MsrBUniRule annotation (EC:1.8.4.12UniRule annotation)
Alternative name(s):
Peptide-methionine (R)-S-oxide reductaseUniRule annotation
Gene namesi
Name:msrBUniRule annotation
Ordered Locus Names:SF1445, S1560
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001402941 – 137Peptide methionine sulfoxide reductase MsrBAdd BLAST137

Proteomic databases

PaxDbiQ83L66.

Interactioni

Protein-protein interaction databases

STRINGi198214.SF1445.

Structurei

3D structure databases

ProteinModelPortaliQ83L66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 129MsrBPROSITE-ProRule annotationAdd BLAST123

Sequence similaritiesi

Belongs to the MsrB Met sulfoxide reductase family.UniRule annotation
Contains 1 MsrB (methionine-R-sulfoxide reductase) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105E0X. Bacteria.
COG0229. LUCA.
HOGENOMiHOG000243425.
KOiK07305.
OMAiRIEVQCK.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83L66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKPSAEEL KKNLSEMQFY VTQNHGTEPP FTGRLLHNKR DGVYHCLICD
60 70 80 90 100
APLFHSETKY DSGCGWPSFY EPVSEESIRY IKDLSHGMQR IEIRCGNCDA
110 120 130
HLGHVFPDGP QPTGERYCVN SASLRFTDGE NGEEING
Length:137
Mass (Da):15,452
Last modified:June 1, 2003 - v1
Checksum:i615B62E77EA4CF71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43043.1.
AE014073 Genomic DNA. Translation: AAP16938.1.
RefSeqiNP_707336.1. NC_004337.2.
WP_001284613.1. NZ_LVJC01000058.1.

Genome annotation databases

EnsemblBacteriaiAAN43043; AAN43043; SF1445.
AAP16938; AAP16938; S1560.
GeneIDi1024628.
KEGGisfl:SF1445.
sft:NCTC1_01554.
sfx:S1560.
PATRICi18704442. VBIShiFle31049_1724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43043.1.
AE014073 Genomic DNA. Translation: AAP16938.1.
RefSeqiNP_707336.1. NC_004337.2.
WP_001284613.1. NZ_LVJC01000058.1.

3D structure databases

ProteinModelPortaliQ83L66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF1445.

Proteomic databases

PaxDbiQ83L66.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN43043; AAN43043; SF1445.
AAP16938; AAP16938; S1560.
GeneIDi1024628.
KEGGisfl:SF1445.
sft:NCTC1_01554.
sfx:S1560.
PATRICi18704442. VBIShiFle31049_1724.

Phylogenomic databases

eggNOGiENOG4105E0X. Bacteria.
COG0229. LUCA.
HOGENOMiHOG000243425.
KOiK07305.
OMAiRIEVQCK.

Family and domain databases

Gene3Di2.170.150.20. 1 hit.
HAMAPiMF_01400. MsrB. 1 hit.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002579. Met_Sox_Rdtase_MsrB.
IPR011057. Mss4-like.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01641. SelR. 1 hit.
[Graphical view]
SUPFAMiSSF51316. SSF51316. 1 hit.
TIGRFAMsiTIGR00357. TIGR00357. 1 hit.
PROSITEiPS51790. MSRB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMSRB_SHIFL
AccessioniPrimary (citable) accession number: Q83L66
Secondary accession number(s): Q7C1P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.