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Protein

Phenylalanine--tRNA ligase beta subunit

Gene

pheT

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per tetramer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi454MagnesiumUniRule annotation1
Metal bindingi460Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi463MagnesiumUniRule annotation1
Metal bindingi464MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase, RNA-binding, tRNA-binding
Biological processProtein biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phenylalanine--tRNA ligase beta subunitUniRule annotation (EC:6.1.1.20UniRule annotation)
Alternative name(s):
Phenylalanyl-tRNA synthetase beta subunitUniRule annotation
Short name:
PheRSUniRule annotation
Gene namesi
Name:pheTUniRule annotation
Ordered Locus Names:SF1518, S1635
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001269461 – 795Phenylalanine--tRNA ligase beta subunitAdd BLAST795

Proteomic databases

PRIDEiQ83L36

Interactioni

Subunit structurei

Tetramer of two alpha and two beta subunits.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ83L36
SMRiQ83L36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 148tRNA-bindingUniRule annotationAdd BLAST110
Domaini401 – 476B5UniRule annotationAdd BLAST76
Domaini701 – 794FDX-ACBUniRule annotationAdd BLAST94

Sequence similaritiesi

Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C6A Bacteria
COG0072 LUCA
COG0073 LUCA
HOGENOMiHOG000292085
KOiK01890
OMAiLTPNRSD

Family and domain databases

CDDicd02796 tRNA_bind_bactPheRS, 1 hit
Gene3Di3.30.70.380, 1 hit
3.50.40.10, 1 hit
HAMAPiMF_00283 Phe_tRNA_synth_beta1, 1 hit
InterProiView protein in InterPro
IPR005146 B3/B4_tRNA-bd
IPR009061 DNA-bd_dom_put_sf
IPR005121 Fdx_antiC-bd
IPR036690 Fdx_antiC-bd_sf
IPR012340 NA-bd_OB-fold
IPR004532 Phe-tRNA-ligase_IIc_bsu
IPR020825 Phe-tRNA_synthase_B3/B4
IPR002547 tRNA-bd_dom
IPR033714 tRNA_bind_bactPheRS
IPR005147 tRNA_synthase_B5-dom
PfamiView protein in Pfam
PF03483 B3_4, 1 hit
PF03484 B5, 1 hit
PF03147 FDX-ACB, 1 hit
PF01588 tRNA_bind, 1 hit
SMARTiView protein in SMART
SM00873 B3_4, 1 hit
SM00874 B5, 1 hit
SM00896 FDX-ACB, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit
SSF50249 SSF50249, 1 hit
SSF54991 SSF54991, 1 hit
TIGRFAMsiTIGR00472 pheT_bact, 1 hit
PROSITEiView protein in PROSITE
PS51483 B5, 1 hit
PS51447 FDX_ACB, 1 hit
PS50886 TRBD, 1 hit

Sequencei

Sequence statusi: Complete.

Q83L36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFSELWLRE WVNPAIDSDT LANQITMAGL EVDGVEPVAG SFHGVVVGEV
60 70 80 90 100
VECAQHPNAD KLRVTKVNVG GDRLLDIVCG APNCRQGLRV AVATIGAVLP
110 120 130 140 150
GDFKIKAAKL RGEPSEGMLC SFSELGISDD HSGIIELPAD APIGTDIREY
160 170 180 190 200
LKLDDNTIEI SVTPNRADCL GIIGVARDVA VLNQLPLVEP EIVPVGATID
210 220 230 240 250
DTLPITVEAP EACPRYLGRV VKGINVKAPT PLWMKEKLRR CGIRSIDAVV
260 270 280 290 300
DVTNYVLLEL GQPMHAFDKD RIEGGIVVRM AKEGETLVLL DGTEAKLNAD
310 320 330 340 350
TLVIADHNKA LAMGGIFGGE HSGVNDETQN VLLECAFFSP LSITGRARRH
360 370 380 390 400
GLHTDASHRY ERGVDPVLQH KAMERATRLL IDICGGEAGP VIDITNEATL
410 420 430 440 450
PKRATITLRR SKLDRLIGHH IADEQVTDIL RRLGCEVTEG KDEWQAVAPS
460 470 480 490 500
WRFDMEIEED LVEEVARVYG YNNIPDEPVQ ASLIMGTHRE ADLSLKRVKT
510 520 530 540 550
LLNDKGYQEV ITYSFVDPKV QQMIHPGVEA LLLASPISVE MSAMRLSLWT
560 570 580 590 600
GLLATVVYNQ NRQQNRVRIF ESGLRFVPDT QAPLGIRQDL MLAGVICGNR
610 620 630 640 650
YEEHWNLAKE TVDFYDLKGD LESVLDLTGK LNEVEFRAEA NPALHPGQSA
660 670 680 690 700
AIYLKGERIG FVGVVHPELE RKLDLNGRTL VFELEWNKLA DRVVPQAREI
710 720 730 740 750
SRFPANRRDI AVVVAENVPA ADILSECKKV GVNQVVGVNL FDVYRGKGVA
760 770 780 790
EGYKSLAISL ILQDTSRTLE EEEIAATVAK CVEALKERFQ ASLRD
Length:795
Mass (Da):87,411
Last modified:June 1, 2003 - v1
Checksum:i7F59E6BE805AB0A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA Translation: AAN43108.1
AE014073 Genomic DNA Translation: AAP16998.1
RefSeqiNP_707401.1, NC_004337.2
WP_000672419.1, NZ_MSKD02000094.1

Genome annotation databases

EnsemblBacteriaiAAN43108; AAN43108; SF1518
AAP16998; AAP16998; S1635
GeneIDi1024717
KEGGisfl:SF1518
sfx:S1635
PATRICifig|198214.7.peg.1793

Similar proteinsi

Entry informationi

Entry nameiSYFB_SHIFL
AccessioniPrimary (citable) accession number: Q83L36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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