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Protein

Probable lipid kinase YegS

Gene

yegS

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probably phosphorylates lipids; the in vivo substrate is unknown.UniRule annotation

Cofactori

Mg2+UniRule annotation, Ca2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. Ca2+ may be able to substitute.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40ATPUniRule annotation1
Binding sitei95ATPUniRule annotation1
Metal bindingi215Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi218MagnesiumUniRule annotation1
Metal bindingi220Magnesium; via carbonyl oxygenUniRule annotation1
Active sitei271Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 72ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lipid kinase YegSUniRule annotation (EC:2.7.1.-UniRule annotation)
Gene namesi
Name:yegSUniRule annotation
Ordered Locus Names:SF2149, S2274
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002921601 – 299Probable lipid kinase YegSAdd BLAST299

Proteomic databases

PaxDbiQ83KI0.

Interactioni

Protein-protein interaction databases

STRINGi198214.SF2149.

Structurei

3D structure databases

ProteinModelPortaliQ83KI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 133DAGKcUniRule annotationAdd BLAST132

Sequence similaritiesi

Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.UniRule annotation
Contains 1 DAGKc domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107TE5. Bacteria.
COG1597. LUCA.
HOGENOMiHOG000261396.
OMAiDFSWQGD.

Family and domain databases

HAMAPiMF_01377. YegS. 1 hit.
InterProiIPR005218. Diacylglycerol/lipid_kinase.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR022433. Lip_kinase_YegS.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
TIGRFAMsiTIGR03702. lip_kinase_YegS. 1 hit.
TIGR00147. TIGR00147. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83KI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFPASLLI LNGKSTDNLP LREAIMLLRE EGMTIHVRVT WEKGDAARFV
60 70 80 90 100
EEARKLGVAT VIAGGGDGTI NEVCTALIQC EGDDIPALGI LPLGTANDFA
110 120 130 140 150
TSVGIPEALD KALKLAIAGN AIAIDMAQVN KQTCFINMAT GGFGTRITTE
160 170 180 190 200
TPEKLKAALG GVSYIIHGLM RMDTLQPDRC EIRGENFHWQ GDALVIGIGN
210 220 230 240 250
GRQAGGGQQL CPNALINDGL LQLRIFTGDE ILPALVSTLK SDEDNPNIIE
260 270 280 290
GASSWFDIQA PHEITFNLDG EPLSGQNFHI EILPAALRCR LPPDCPLLR
Length:299
Mass (Da):31,988
Last modified:June 1, 2003 - v1
Checksum:i7F01F5F533D3E6A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74C → S in AAP17508 (PubMed:12704152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43682.1.
AE014073 Genomic DNA. Translation: AAP17508.1.
RefSeqiNP_707975.1. NC_004337.2.

Genome annotation databases

EnsemblBacteriaiAAN43682; AAN43682; SF2149.
AAP17508; AAP17508; S2274.
GeneIDi1025346.
KEGGisfl:SF2149.
sfx:S2274.
PATRICi18706069. VBIShiFle31049_2512.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN43682.1.
AE014073 Genomic DNA. Translation: AAP17508.1.
RefSeqiNP_707975.1. NC_004337.2.

3D structure databases

ProteinModelPortaliQ83KI0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi198214.SF2149.

Proteomic databases

PaxDbiQ83KI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN43682; AAN43682; SF2149.
AAP17508; AAP17508; S2274.
GeneIDi1025346.
KEGGisfl:SF2149.
sfx:S2274.
PATRICi18706069. VBIShiFle31049_2512.

Phylogenomic databases

eggNOGiENOG4107TE5. Bacteria.
COG1597. LUCA.
HOGENOMiHOG000261396.
OMAiDFSWQGD.

Family and domain databases

HAMAPiMF_01377. YegS. 1 hit.
InterProiIPR005218. Diacylglycerol/lipid_kinase.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR022433. Lip_kinase_YegS.
IPR016064. NAD/diacylglycerol_kinase.
[Graphical view]
PfamiPF00781. DAGK_cat. 1 hit.
[Graphical view]
SMARTiSM00046. DAGKc. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
TIGRFAMsiTIGR03702. lip_kinase_YegS. 1 hit.
TIGR00147. TIGR00147. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYEGS_SHIFL
AccessioniPrimary (citable) accession number: Q83KI0
Secondary accession number(s): Q7UCB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.