Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable lipid kinase YegS

Gene

yegS

Organism
Shigella flexneri
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Probably phosphorylates lipids; the in vivo substrate is unknown.UniRule annotation

Cofactori

Mg2+UniRule annotation, Ca2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit. Ca2+ may be able to substitute.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40ATPUniRule annotation1
Binding sitei95ATPUniRule annotation1
Metal bindingi215Magnesium; via carbonyl oxygenUniRule annotation1
Metal bindingi218MagnesiumUniRule annotation1
Metal bindingi220Magnesium; via carbonyl oxygenUniRule annotation1
Active sitei271Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 72ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lipid kinase YegSUniRule annotation (EC:2.7.1.-UniRule annotation)
Gene namesi
Name:yegSUniRule annotation
Ordered Locus Names:SF2149, S2274
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002921601 – 299Probable lipid kinase YegSAdd BLAST299

Structurei

3D structure databases

ProteinModelPortaliQ83KI0
SMRiQ83KI0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 133DAGKcUniRule annotationAdd BLAST132

Sequence similaritiesi

Belongs to the diacylglycerol/lipid kinase family. YegS lipid kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107TE5 Bacteria
COG1597 LUCA
HOGENOMiHOG000261396
OMAiVNSCVGG

Family and domain databases

Gene3Di3.40.50.10330, 2 hits
HAMAPiMF_01377 YegS, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR005218 Diacylglycerol/lipid_kinase
IPR001206 Diacylglycerol_kinase_cat_dom
IPR022433 Lip_kinase_YegS
IPR016064 NAD/diacylglycerol_kinase_sf
PfamiView protein in Pfam
PF00781 DAGK_cat, 1 hit
SMARTiView protein in SMART
SM00046 DAGKc, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit
TIGRFAMsiTIGR03702 lip_kinase_YegS, 1 hit
TIGR00147 TIGR00147, 1 hit
PROSITEiView protein in PROSITE
PS50146 DAGK, 1 hit

Sequencei

Sequence statusi: Complete.

Q83KI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFPASLLI LNGKSTDNLP LREAIMLLRE EGMTIHVRVT WEKGDAARFV
60 70 80 90 100
EEARKLGVAT VIAGGGDGTI NEVCTALIQC EGDDIPALGI LPLGTANDFA
110 120 130 140 150
TSVGIPEALD KALKLAIAGN AIAIDMAQVN KQTCFINMAT GGFGTRITTE
160 170 180 190 200
TPEKLKAALG GVSYIIHGLM RMDTLQPDRC EIRGENFHWQ GDALVIGIGN
210 220 230 240 250
GRQAGGGQQL CPNALINDGL LQLRIFTGDE ILPALVSTLK SDEDNPNIIE
260 270 280 290
GASSWFDIQA PHEITFNLDG EPLSGQNFHI EILPAALRCR LPPDCPLLR
Length:299
Mass (Da):31,988
Last modified:June 1, 2003 - v1
Checksum:i7F01F5F533D3E6A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti74C → S in AAP17508 (PubMed:12704152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA Translation: AAN43682.1
AE014073 Genomic DNA Translation: AAP17508.1
RefSeqiNP_707975.1, NC_004337.2

Genome annotation databases

EnsemblBacteriaiAAN43682; AAN43682; SF2149
AAP17508; AAP17508; S2274
GeneIDi1025346
KEGGisfl:SF2149
sfx:S2274
PATRICifig|198214.7.peg.2563

Similar proteinsi

Entry informationi

Entry nameiYEGS_SHIFL
AccessioniPrimary (citable) accession number: Q83KI0
Secondary accession number(s): Q7UCB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: June 1, 2003
Last modified: April 25, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health