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Protein

5'/3'-nucleotidase SurE

Gene

surE

Organism
Shigella flexneri
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.UniRule annotation

Catalytic activityi

A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.UniRule annotation

Cofactori

a divalent metal cationUniRule annotationNote: Binds 1 divalent metal cation per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi9Divalent metal cationUniRule annotation1
Metal bindingi39Divalent metal cationUniRule annotation1
Metal bindingi92Divalent metal cationUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
5'/3'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation, EC:3.1.3.6UniRule annotation)
Alternative name(s):
ExopolyphosphataseUniRule annotation (EC:3.6.1.11UniRule annotation)
Nucleoside monophosphate phosphohydrolaseUniRule annotation
Gene namesi
Name:surEUniRule annotation
Ordered Locus Names:SF2767, S2960
OrganismiShigella flexneri
Taxonomic identifieri623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeShigella
Proteomesi
  • UP000002673 Componenti: Chromosome
  • UP000001006 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001118421 – 2535'/3'-nucleotidase SurEAdd BLAST253

Proteomic databases

PaxDbiQ83JY2.

Structurei

3D structure databases

ProteinModelPortaliQ83JY2.
SMRiQ83JY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SurE nucleotidase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CV2. Bacteria.
COG0496. LUCA.
HOGENOMiHOG000122500.
KOiK03787.
OMAiDCVHIAL.

Family and domain databases

Gene3Di3.40.1210.10. 1 hit.
HAMAPiMF_00060. SurE. 1 hit.
InterProiView protein in InterPro
IPR030048. SurE.
IPR002828. SurE-like_Pase/nucleotidase.
PfamiView protein in Pfam
PF01975. SurE. 1 hit.
SUPFAMiSSF64167. SSF64167. 1 hit.
TIGRFAMsiTIGR00087. surE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83JY2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRILLSNYDG VHAPGIQTLA KALREFADVQ VVAPDRNRSG ASNSLTLESS
60 70 80 90 100
LRTFTFENGD IAVQMGTPTD CVYLGVNALM RPRPDIVVSG INAGPNLGDD
110 120 130 140 150
VIYSGTVAAA MEGRHLGFPA LAVSLDGHKH YDTAAAVTCS ILRALCKEPL
160 170 180 190 200
RTGRILNINV QDLPLDQIKG IRVTRCGTRH PADQVIPQQD PRGNTLYWIG
210 220 230 240 250
PPGGKCDAGP GTDFAAVDEG YVSITPLHVD LTAHSAQDVV SDWLNSVGVG

TQW
Length:253
Mass (Da):26,980
Last modified:December 15, 2003 - v2
Checksum:i191A97BAEF07A082
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005674 Genomic DNA. Translation: AAN44256.2.
AE014073 Genomic DNA. Translation: AAP18082.1.
RefSeqiNP_708549.2. NC_004337.2.
WP_011069490.1. NZ_MSKD02000183.1.

Genome annotation databases

EnsemblBacteriaiAAN44256; AAN44256; SF2767.
AAP18082; AAP18082; S2960.
GeneIDi1025770.
KEGGisfl:SF2767.
sfx:S2960.
PATRICifig|198214.7.peg.3294.

Similar proteinsi

Entry informationi

Entry nameiSURE_SHIFL
AccessioniPrimary (citable) accession number: Q83JY2
Secondary accession number(s): Q7UBT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: December 15, 2003
Last modified: September 27, 2017
This is version 94 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Tyr-8 is present instead of the conserved Asp which is expected to be a metal-binding site residue.Curated

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families