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Q83JY2

- SURE_SHIFL

UniProt

Q83JY2 - SURE_SHIFL

Protein

5'/3'-nucleotidase SurE

Gene

surE

Organism
Shigella flexneri
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 2 (15 Dec 2003)
      Previous versions | rss
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    Functioni

    Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs.UniRule annotation

    Catalytic activityi

    A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
    A 3'-ribonucleotide + H2O = a ribonucleoside + phosphate.UniRule annotation
    (Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.UniRule annotation

    Cofactori

    Binds 1 divalent metal cation per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi9 – 91Divalent metal cationUniRule annotation
    Metal bindingi39 – 391Divalent metal cationUniRule annotation
    Metal bindingi92 – 921Divalent metal cationUniRule annotation

    GO - Molecular functioni

    1. 3'-nucleotidase activity Source: UniProtKB-HAMAP
    2. 5'-nucleotidase activity Source: UniProtKB-HAMAP
    3. exopolyphosphatase activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-HAMAP
    5. nucleotide binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5'/3'-nucleotidase SurEUniRule annotation (EC:3.1.3.5UniRule annotation, EC:3.1.3.6UniRule annotation)
    Alternative name(s):
    ExopolyphosphataseUniRule annotation (EC:3.6.1.11UniRule annotation)
    Nucleoside monophosphate phosphohydrolaseUniRule annotation
    Gene namesi
    Name:surEUniRule annotation
    Ordered Locus Names:SF2767, S2960
    OrganismiShigella flexneri
    Taxonomic identifieri623 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeShigella
    ProteomesiUP000001006: Chromosome, UP000002673: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2532535'/3'-nucleotidase SurEPRO_0000111842Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi198214.SF2767.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83JY2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SurE nucleotidase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0496.
    HOGENOMiHOG000122500.
    KOiK03787.
    OrthoDBiEOG68WR45.

    Family and domain databases

    Gene3Di3.40.1210.10. 1 hit.
    HAMAPiMF_00060. SurE.
    InterProiIPR002828. SurE-like_Pase/nucleotidase.
    [Graphical view]
    PfamiPF01975. SurE. 1 hit.
    [Graphical view]
    SUPFAMiSSF64167. SSF64167. 1 hit.
    TIGRFAMsiTIGR00087. surE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q83JY2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRILLSNYDG VHAPGIQTLA KALREFADVQ VVAPDRNRSG ASNSLTLESS    50
    LRTFTFENGD IAVQMGTPTD CVYLGVNALM RPRPDIVVSG INAGPNLGDD 100
    VIYSGTVAAA MEGRHLGFPA LAVSLDGHKH YDTAAAVTCS ILRALCKEPL 150
    RTGRILNINV QDLPLDQIKG IRVTRCGTRH PADQVIPQQD PRGNTLYWIG 200
    PPGGKCDAGP GTDFAAVDEG YVSITPLHVD LTAHSAQDVV SDWLNSVGVG 250
    TQW 253
    Length:253
    Mass (Da):26,980
    Last modified:December 15, 2003 - v2
    Checksum:i191A97BAEF07A082
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN44256.2.
    AE014073 Genomic DNA. Translation: AAP18082.1.
    RefSeqiNP_708549.2. NC_004337.2.
    NP_838272.1. NC_004741.1.

    Genome annotation databases

    EnsemblBacteriaiAAN44256; AAN44256; SF2767.
    AAP18082; AAP18082; S2960.
    GeneIDi1025770.
    1079225.
    KEGGisfl:SF2767.
    sfx:S2960.
    PATRICi18707590. VBIShiFle31049_3250.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005674 Genomic DNA. Translation: AAN44256.2 .
    AE014073 Genomic DNA. Translation: AAP18082.1 .
    RefSeqi NP_708549.2. NC_004337.2.
    NP_838272.1. NC_004741.1.

    3D structure databases

    ProteinModelPortali Q83JY2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 198214.SF2767.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN44256 ; AAN44256 ; SF2767 .
    AAP18082 ; AAP18082 ; S2960 .
    GeneIDi 1025770.
    1079225.
    KEGGi sfl:SF2767.
    sfx:S2960.
    PATRICi 18707590. VBIShiFle31049_3250.

    Phylogenomic databases

    eggNOGi COG0496.
    HOGENOMi HOG000122500.
    KOi K03787.
    OrthoDBi EOG68WR45.

    Family and domain databases

    Gene3Di 3.40.1210.10. 1 hit.
    HAMAPi MF_00060. SurE.
    InterProi IPR002828. SurE-like_Pase/nucleotidase.
    [Graphical view ]
    Pfami PF01975. SurE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64167. SSF64167. 1 hit.
    TIGRFAMsi TIGR00087. surE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Shigella flexneri 2a: insights into pathogenicity through comparison with genomes of Escherichia coli K12 and O157."
      Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J., Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L., Xue Y.
      , Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H., Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.
      Nucleic Acids Res. 30:4432-4441(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 301 / Serotype 2a.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 700930 / 2457T / Serotype 2a.

    Entry informationi

    Entry nameiSURE_SHIFL
    AccessioniPrimary (citable) accession number: Q83JY2
    Secondary accession number(s): Q7UBT1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: December 15, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Caution

    Tyr-8 is present instead of the conserved Asp which is expected to be a metal-binding site residue.Curated

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3