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Q83IC3

- NADK_TROW8

UniProt

Q83IC3 - NADK_TROW8

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Protein

NAD kinase

Gene
nadK, TW112
Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptor By similarity
Binding sitei93 – 931NAD By similarity
Binding sitei173 – 1731NAD By similarity
Binding sitei192 – 1921NAD By similarity
Binding sitei262 – 2621NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi88 – 892NAD By similarity
Nucleotide bindingi162 – 1632NAD By similarity
Nucleotide bindingi203 – 2086NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:TW112
OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Taxonomic identifieri218496 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000001413: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305NAD kinaseUniRule annotationPRO_0000120684Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218496.TW112.

Structurei

3D structure databases

ProteinModelPortaliQ83IC3.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000115663.
KOiK00858.
OMAiGVLWCDG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83IC3-1 [UniParc]FASTAAdd to Basket

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MRVYIAHNGC LEAEPIYGTI CELVAQRKMS VITDPHARNN ESARNTDSGV    50
VSLNQAGRNK YLDQETTSPA TSRSINVPFC AGISIGGDGT FLRMARDLKN 100
TGTPLFGVNM GRMGFLVDIE PEDIVNLVEN IVKGEYTEEK RLPITASVQR 150
GGKKIHDEWA VNEITIERKV EGKVVDIEVF VDGCRVMDIS CNGIIIATAT 200
GSTAYSFSSG GPIVWPEMKV TLVVPVSPHE LFAKPIVLPD NRSILLKVTS 250
RDNKVVLCSD GQVRLCLQSG DEIACHVGKV PVVFGRVKKG CFAEHLVKKF 300
NLQTA 305
Length:305
Mass (Da):33,273
Last modified:June 1, 2003 - v1
Checksum:iC53563B959052E5D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX251410 Genomic DNA. Translation: CAD66795.1.
RefSeqiNP_789058.1. NC_004551.1.

Genome annotation databases

EnsemblBacteriaiCAD66795; CAD66795; TW112.
GeneIDi1064410.
KEGGitws:TW112.
PATRICi23998574. VBITroWhi42739_0133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX251410 Genomic DNA. Translation: CAD66795.1 .
RefSeqi NP_789058.1. NC_004551.1.

3D structure databases

ProteinModelPortali Q83IC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218496.TW112.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD66795 ; CAD66795 ; TW112 .
GeneIDi 1064410.
KEGGi tws:TW112.
PATRICi 23998574. VBITroWhi42739_0133.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000115663.
KOi K00858.
OMAi GVLWCDG.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW08/27.

Entry informationi

Entry nameiNADK_TROW8
AccessioniPrimary (citable) accession number: Q83IC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi