Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q83IA7

- GCSP_TROW8

UniProt

Q83IA7 - GCSP_TROW8

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:TW144
    OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
    Taxonomic identifieri218496 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
    ProteomesiUP000001413: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 968968Glycine dehydrogenase (decarboxylating)PRO_0000166943Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei717 – 7171N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi218496.TW144.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83IA7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR000192. Aminotrans_V/Cys_dSase.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF00266. Aminotran_5. 1 hit.
    PF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q83IA7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHERHIGPSQ EEIDHMLGFL GYKSLDDLMH AALPNGVQSP PDIKIPSHDE    50
    LTCLTQLAAF AKMNRIKTSM LGQGFYNCIT PAVIRRNILE NPSWYTSYTP 100
    YQPEISQGRL EMLINFQTMI CDLTGLEIAN ASMLDEASCA AEAMLLAKRV 150
    SRSSSNKYLV HNGVFPHIRR VLETRADAVG VEIVDLPEGQ SIDFDHFGVY 200
    AQYQSASGKL LDLRPLFSRS KRAGAICVIG CDLLMLTLFT SPGELGADIA 250
    FGSAQRFGIP MNFGGPLASF LAARKAMERS LPGRLVGVSV DADSNHAYRL 300
    TLQTREQHIR REKATSNICT ATVLMAIAAV AFAQHHGPKG LRAIAHRINT 350
    VAVGFARLLK QTAFRVSSLD IFDTIEINNP TQVCVEAESK YDLLFWKVDD 400
    NKLRITFDEV TARLDGDLPE RLSKVFGISP DKIRDLGCNY DSCDCSFYGD 450
    LQQAREGLSS VASRNISVHS DLARHPLRRF SGYLKHPVFN NYTGEVALMR 500
    YLKALSDKDF ALDRGMIPLG SCTMKLNAAF QLEPVLWPEF ANLHPFAPLG 550
    DADGTLQIID QIETWLANLS GYDAVSLQPT AGSQGELAGL LAIRGYYKSL 600
    NLDRDVCLIP ASAHGTNAAS AVLAGMRVVV VACDQQGNID LDDLRLKASK 650
    NAHALAALMV TYPSTHGVYE DNISEVCSVV HKYGGQVYVD GANSNALIGY 700
    LRTGDFGGDV SHLNLHKTFG IPHGGGGPGI GPVVAKAHLA PFLPFRNRVH 750
    KPSTDLPAVK HMGGPIASSD YGFAGALYIS WAYIFCLGSQ GMKRCTAVAV 800
    LVANYIAKQL SDTFPVLYTG KNNLVAHEFI MDFREVTRVS GITVDDVCKR 850
    LIDYGFHAPT MSFPVPGTLM VEPTESEPFS EIQRFIKTIR SIRAEIDRVI 900
    DKTYDPDNNP LKRAPHTLEQ IASDKWDRPY SRRTGIVYTS GKYWPASARI 950
    DNAYGDRNIF CTCPDLPD 968
    Length:968
    Mass (Da):106,355
    Last modified:June 1, 2003 - v1
    Checksum:i1E675DF9A0AF4D89
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX251410 Genomic DNA. Translation: CAD66824.1.
    RefSeqiNP_789087.1. NC_004551.1.

    Genome annotation databases

    EnsemblBacteriaiCAD66824; CAD66824; TW144.
    GeneIDi1064439.
    KEGGitws:TW144.
    PATRICi23998639. VBITroWhi42739_0164.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX251410 Genomic DNA. Translation: CAD66824.1 .
    RefSeqi NP_789087.1. NC_004551.1.

    3D structure databases

    ProteinModelPortali Q83IA7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218496.TW144.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD66824 ; CAD66824 ; TW144 .
    GeneIDi 1064439.
    KEGGi tws:TW144.
    PATRICi 23998639. VBITroWhi42739_0164.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR000192. Aminotrans_V/Cys_dSase.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF00266. Aminotran_5. 1 hit.
    PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW08/27.

    Entry informationi

    Entry nameiGCSP_TROW8
    AccessioniPrimary (citable) accession number: Q83IA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3