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Q83IA7

- GCSP_TROW8

UniProt

Q83IA7 - GCSP_TROW8

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Protein

Glycine dehydrogenase (decarboxylating)

Gene
gcvP, TW144
Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:TW144
OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Taxonomic identifieri218496 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000001413: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 968968Glycine dehydrogenase (decarboxylating)UniRule annotationPRO_0000166943Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei717 – 7171N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi218496.TW144.

Structurei

3D structure databases

ProteinModelPortaliQ83IA7.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83IA7-1 [UniParc]FASTAAdd to Basket

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MHERHIGPSQ EEIDHMLGFL GYKSLDDLMH AALPNGVQSP PDIKIPSHDE    50
LTCLTQLAAF AKMNRIKTSM LGQGFYNCIT PAVIRRNILE NPSWYTSYTP 100
YQPEISQGRL EMLINFQTMI CDLTGLEIAN ASMLDEASCA AEAMLLAKRV 150
SRSSSNKYLV HNGVFPHIRR VLETRADAVG VEIVDLPEGQ SIDFDHFGVY 200
AQYQSASGKL LDLRPLFSRS KRAGAICVIG CDLLMLTLFT SPGELGADIA 250
FGSAQRFGIP MNFGGPLASF LAARKAMERS LPGRLVGVSV DADSNHAYRL 300
TLQTREQHIR REKATSNICT ATVLMAIAAV AFAQHHGPKG LRAIAHRINT 350
VAVGFARLLK QTAFRVSSLD IFDTIEINNP TQVCVEAESK YDLLFWKVDD 400
NKLRITFDEV TARLDGDLPE RLSKVFGISP DKIRDLGCNY DSCDCSFYGD 450
LQQAREGLSS VASRNISVHS DLARHPLRRF SGYLKHPVFN NYTGEVALMR 500
YLKALSDKDF ALDRGMIPLG SCTMKLNAAF QLEPVLWPEF ANLHPFAPLG 550
DADGTLQIID QIETWLANLS GYDAVSLQPT AGSQGELAGL LAIRGYYKSL 600
NLDRDVCLIP ASAHGTNAAS AVLAGMRVVV VACDQQGNID LDDLRLKASK 650
NAHALAALMV TYPSTHGVYE DNISEVCSVV HKYGGQVYVD GANSNALIGY 700
LRTGDFGGDV SHLNLHKTFG IPHGGGGPGI GPVVAKAHLA PFLPFRNRVH 750
KPSTDLPAVK HMGGPIASSD YGFAGALYIS WAYIFCLGSQ GMKRCTAVAV 800
LVANYIAKQL SDTFPVLYTG KNNLVAHEFI MDFREVTRVS GITVDDVCKR 850
LIDYGFHAPT MSFPVPGTLM VEPTESEPFS EIQRFIKTIR SIRAEIDRVI 900
DKTYDPDNNP LKRAPHTLEQ IASDKWDRPY SRRTGIVYTS GKYWPASARI 950
DNAYGDRNIF CTCPDLPD 968
Length:968
Mass (Da):106,355
Last modified:June 1, 2003 - v1
Checksum:i1E675DF9A0AF4D89
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX251410 Genomic DNA. Translation: CAD66824.1.
RefSeqiNP_789087.1. NC_004551.1.

Genome annotation databases

EnsemblBacteriaiCAD66824; CAD66824; TW144.
GeneIDi1064439.
KEGGitws:TW144.
PATRICi23998639. VBITroWhi42739_0164.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX251410 Genomic DNA. Translation: CAD66824.1 .
RefSeqi NP_789087.1. NC_004551.1.

3D structure databases

ProteinModelPortali Q83IA7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218496.TW144.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD66824 ; CAD66824 ; TW144 .
GeneIDi 1064439.
KEGGi tws:TW144.
PATRICi 23998639. VBITroWhi42739_0164.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW08/27.

Entry informationi

Entry nameiGCSP_TROW8
AccessioniPrimary (citable) accession number: Q83IA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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