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Q83IA7 (GCSP_TROW8) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:TW144
OrganismTropheryma whipplei (strain TW08/27) (Whipple's bacillus) [Complete proteome] [HAMAP]
Taxonomic identifier218496 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma

Protein attributes

Sequence length968 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 968968Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166943

Amino acid modifications

Modified residue7171N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83IA7 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 1E675DF9A0AF4D89

FASTA968106,355
        10         20         30         40         50         60 
MHERHIGPSQ EEIDHMLGFL GYKSLDDLMH AALPNGVQSP PDIKIPSHDE LTCLTQLAAF 

        70         80         90        100        110        120 
AKMNRIKTSM LGQGFYNCIT PAVIRRNILE NPSWYTSYTP YQPEISQGRL EMLINFQTMI 

       130        140        150        160        170        180 
CDLTGLEIAN ASMLDEASCA AEAMLLAKRV SRSSSNKYLV HNGVFPHIRR VLETRADAVG 

       190        200        210        220        230        240 
VEIVDLPEGQ SIDFDHFGVY AQYQSASGKL LDLRPLFSRS KRAGAICVIG CDLLMLTLFT 

       250        260        270        280        290        300 
SPGELGADIA FGSAQRFGIP MNFGGPLASF LAARKAMERS LPGRLVGVSV DADSNHAYRL 

       310        320        330        340        350        360 
TLQTREQHIR REKATSNICT ATVLMAIAAV AFAQHHGPKG LRAIAHRINT VAVGFARLLK 

       370        380        390        400        410        420 
QTAFRVSSLD IFDTIEINNP TQVCVEAESK YDLLFWKVDD NKLRITFDEV TARLDGDLPE 

       430        440        450        460        470        480 
RLSKVFGISP DKIRDLGCNY DSCDCSFYGD LQQAREGLSS VASRNISVHS DLARHPLRRF 

       490        500        510        520        530        540 
SGYLKHPVFN NYTGEVALMR YLKALSDKDF ALDRGMIPLG SCTMKLNAAF QLEPVLWPEF 

       550        560        570        580        590        600 
ANLHPFAPLG DADGTLQIID QIETWLANLS GYDAVSLQPT AGSQGELAGL LAIRGYYKSL 

       610        620        630        640        650        660 
NLDRDVCLIP ASAHGTNAAS AVLAGMRVVV VACDQQGNID LDDLRLKASK NAHALAALMV 

       670        680        690        700        710        720 
TYPSTHGVYE DNISEVCSVV HKYGGQVYVD GANSNALIGY LRTGDFGGDV SHLNLHKTFG 

       730        740        750        760        770        780 
IPHGGGGPGI GPVVAKAHLA PFLPFRNRVH KPSTDLPAVK HMGGPIASSD YGFAGALYIS 

       790        800        810        820        830        840 
WAYIFCLGSQ GMKRCTAVAV LVANYIAKQL SDTFPVLYTG KNNLVAHEFI MDFREVTRVS 

       850        860        870        880        890        900 
GITVDDVCKR LIDYGFHAPT MSFPVPGTLM VEPTESEPFS EIQRFIKTIR SIRAEIDRVI 

       910        920        930        940        950        960 
DKTYDPDNNP LKRAPHTLEQ IASDKWDRPY SRRTGIVYTS GKYWPASARI DNAYGDRNIF 


CTCPDLPD 

« Hide

References

[1]"Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei."
Bentley S.D., Maiwald M., Murphy L.D., Pallen M.J., Yeats C.A., Dover L.G., Norbertczak H.T., Besra G.S., Quail M.A., Harris D.E., von Herbay A., Goble A., Rutter S., Squares R., Squares S., Barrell B.G., Parkhill J., Relman D.A.
Lancet 361:637-644(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: TW08/27.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BX251410 Genomic DNA. Translation: CAD66824.1.
RefSeqNP_789087.1. NC_004551.1.

3D structure databases

ProteinModelPortalQ83IA7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING218496.TW144.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAD66824; CAD66824; TW144.
GeneID1064439.
KEGGtws:TW144.
PATRIC23998639. VBITroWhi42739_0164.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR000192. Aminotrans_V/Cys_dSase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF00266. Aminotran_5. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_TROW8
AccessionPrimary (citable) accession number: Q83IA7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families