Q83I95 (GCP_TROW8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tRNA threonylcarbamoyladenosine biosynthesis protein Gcp

Alternative name(s):
t(6)A37 threonylcarbamoyladenosine biosynthesis protein

Gene names

Name:	gcp
Ordered Locus Names:	TW170

Organism

Tropheryma whipplei (strain TW08/27) (Whipple's bacillus) [Complete proteome] [HAMAP]

Taxonomic identifier

218496 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine By similarity. HAMAP MF_01445
Subcellular location	Cytoplasm Potential HAMAP MF_01445.
Sequence similarities	Belongs to the KAE1 / YgjD family.

Ontologies

Keywords
Biological process	tRNA processing
Cellular component	Cytoplasm
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro tRNA processing Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Probable tRNA threonylcarbamoyladenosine biosynthesis protein Gcp HAMAP MF_01445		PRO_0000303603

Sequences

	Sequence		Length	Mass (Da)
	Q83I95 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7D12DD242F64DB5D	FASTA	401	42,363
	10 20 30 40 50 60 MSIILGIETS CDETGVGIVS GSTVLANEVA SSSLRHKPFG GVIPEIAARA HLEYLPNLLE 70 80 90 100 110 120 LALETAQLCI KDIDGIAVTA GPGLVTSLSV GVSAAKALGL STGTPVYGVN HLVGHAVSAF 130 140 150 160 170 180 LDDYTNDGLG VIHRRDSIGS NGIENDASST HSHTHTTQVN RHSNLCVYTP PRRVLRDVCK 190 200 210 220 230 240 YMHVRDSVVL LASGGHSCLL KIHNNKISLL GETLDDAAGE AFDKIARLMG LQYPGGPAIE 250 260 270 280 290 300 MLASSGNPNA VEFPRALLTH FEEHNRYSFS FSGLKTAVGR VVERIKSNPA HSIPKIEDIA 310 320 330 340 350 360 ASFQEAVADV LTAKTVAAAL ASDVDLIVMG GGVAANNRIR EMLCERAKIH GLDVKIPPIA 370 380 390 400 LCTDNGAMIA AAGSWLMQLG YNPSHSRFSP VSIMPLTQMV V

References

[1]

"Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei." Bentley S.D., Maiwald M., Murphy L.D., Pallen M.J., Yeats C.A., Dover L.G., Norbertczak H.T., Besra G.S., Quail M.A., Harris D.E., von Herbay A., Goble A., Rutter S., Squares R., Squares S., Barrell B.G., Parkhill J., Relman D.A. Lancet 361:637-644(2003) [PubMed: 12606174] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW08/27.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX251410 Genomic DNA. Translation: CAD66849.1.
RefSeq	NP_789112.1. NC_004551.1.
3D structure databases
ProteinModelPortal	Q83I95.
ModBase	Search...
Protein-protein interaction databases
STRING	Q83I95.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1064464.
GenomeReviews	Gene locus TW170 in contig BX072543_GR.
KEGG	tws:TW170.
PATRIC	23998773. VBITroWhi42739_0227.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0533.
HOGENOM	HBG304663.
OMA	PLYGVNH.
PhylomeDB	Q83I95.
ProtClustDB	PRK09604.
Enzyme and pathway databases
BioCyc	TWHI218496:TW0157-MONOMER.
Family and domain databases
HAMAP	MF_01445. gcp. [Tree]
InterPro	IPR022450. Pept_M22_O-sialoglycopept. IPR000905. Peptidase_M22. IPR017861. Peptidase_M22_subgr. [Graphical view]
KO	K01409.
Pfam	PF00814. Peptidase_M22. 2 hits. [Graphical view]
PRINTS	PR00789. OSIALOPTASE.
PROSITE	PS01016. GLYCOPROTEASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCP_TROW8

Accession

Primary (citable) accession number: Q83I95

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program