Q83I86 (AROA_TROW8) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-phosphoshikimate 1-carboxyvinyltransferase
EC=2.5.1.19

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate synthase
Short name=EPSP synthase
Short name=EPSPS

Gene names

Name:	aroA
Ordered Locus Names:	TW194

Organism

Tropheryma whipplei (strain TW08/27) (Whipple's bacillus) [Complete proteome] [HAMAP]

Taxonomic identifier

218496 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length	443 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. HAMAP MF_00210
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7. HAMAP MF_00210
Subunit structure	Monomer By similarity. HAMAP MF_00210
Subcellular location	Cytoplasm By similarity HAMAP MF_00210.
Sequence similarities	Belongs to the EPSP synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-phosphoshikimate 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 443	443	3-phosphoshikimate 1-carboxyvinyltransferase HAMAP MF_00210		PRO_1000099763

Sequences

	Sequence		Length	Mass (Da)
	Q83I86 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: EE4730740B85E244	FASTA	443	48,072
	10 20 30 40 50 60 MAKTEMYQPP LGNRALFKMS IPGSKSLTNR HLIIAAIASG ETTIHNLLES RDTNLMIEGL 70 80 90 100 110 120 RRIGCKIEKL NHTGTHDTGV ISPHCTCLND LIQPSDVRII PSKHYTCSTK IDCGLAGTVM 130 140 150 160 170 180 RFLPVLAGLC KGSVEFFGDD QAIRRPMDGT LHALRKLGVQ VDGDRIPFTV HGRGEIEGGA 190 200 210 220 230 240 LETTEHSSSQ FISGLLLSAC RFKNGLTLKH IGNPLPSRPY IDMTVEVMRE WGINVTHSDG 250 260 270 280 290 300 VWAVTPKELT GKHITIEPDL SNAAPFMIGA IVTGGSATIQ NWPSKTSQPG KYLEAILPQF 310 320 330 340 350 360 GAEITKTANT ITVSGTGNIT GIRADLGHIG ELVPNLVALA TLAETPSVFY NIGHIRYHET 370 380 390 400 410 420 DRIEALVNEI SSLGGTITAG KDYIKITPTT LTRSGVWKTY KDHRMATSGA IIGLRHKLTI 430 440 EDIECTSKTF PRFADLWSGA FGK

References

[1]

"Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei." Bentley S.D., Maiwald M., Murphy L.D., Pallen M.J., Yeats C.A., Dover L.G., Norbertczak H.T., Besra G.S., Quail M.A., Harris D.E., von Herbay A., Goble A., Rutter S., Squares R., Squares S., Barrell B.G., Parkhill J., Relman D.A. Lancet 361:637-644(2003) [PubMed: 12606174] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TW08/27.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX251410 Genomic DNA. Translation: CAD66871.1.
RefSeq	NP_789134.1. NC_004551.1.
3D structure databases
HSSP	HSSP built from PDB template 2BJB based on UniProtKB P22487.
ProteinModelPortal	Q83I86.
ModBase	Search...
Protein-protein interaction databases
STRING	Q83I86.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1064486.
GenomeReviews	Gene locus TW194 in contig BX072543_GR.
KEGG	tws:TW194.
PATRIC	23998825. VBITroWhi42739_0253.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0128.
HOGENOM	HBG646626.
OMA	HRMATAG.
PhylomeDB	Q83I86.
ProtClustDB	PRK02427.
Enzyme and pathway databases
BioCyc	TWHI218496:TW0179-MONOMER.
Family and domain databases
HAMAP	MF_00210. EPSP_synth. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR006264. EPSP_synthase. IPR023193. EPSP_synthase_CS. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00800.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000505. EPSPS. 1 hit.
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01356. AroA. 1 hit.
PROSITE	PS00104. EPSP_SYNTHASE_1. False negative. PS00885. EPSP_SYNTHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROA_TROW8

Accession

Primary (citable) accession number: Q83I86

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program