Q83I40 (Q83I40_TROW8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
DNA polymerase III alpha subunit EMBL CAD66928.1
EC=2.7.7.7 EMBL CAD66928.1

Gene names

Name:	dnaE EMBL CAD66928.1
Ordered Locus Names:	TW252

Organism

Tropheryma whipplei (strain TW08/27) (Whipple's bacillus) [Complete proteome] [HAMAP]

Taxonomic identifier

218496 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length	1164 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). SAAS SAAS004013

Ontologies

Keywords
Biological process	DNA replication SAAS SAAS004013
Cellular component	Cytoplasm SAAS SAAS004013
Molecular function	DNA-directed DNA polymerase SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q83I40 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 21522EEE20547846	FASTA	1,164	130,845
	10 20 30 40 50 60 MRDYMSFVHL HVHTDYSMLD GAARTEDLMR KAAEDKMPAI AITDHGNTFG AFDFWKTAKT 70 80 90 100 110 120 YDINPIIGME AYLTPGTNRK EKVRKFFASG GPDDVSAGGA YTHLTLLSQN NEGMHNLFKL 130 140 150 160 170 180 SSLASIEGYY FKPRIDIELL NQYSNGLIAT TGCPSGEIQT RLRLGQYSEA RQAAAQMRDI 190 200 210 220 230 240 FGPENYYCEV MDHNLEIEKA VMPDLLRLAG DLGLPLLATN DLHYVNSEDS ASHAALLCVQ 250 260 270 280 290 300 SGSTINDPNR FKFDSDEFYL KSSSEMRILF EDLPEACDNT LLVAERCHIN FDTQRSFMPR 310 320 330 340 350 360 FSVPEGETEN SWFASEVKRG IASRYPNGPS RRVIEQAEYE IRVVQEAGYA GYFLIVADFI 370 380 390 400 410 420 NWAKLNGIRV GPGRGSGAAS MAAYAMRITD LDPLEHGLIF ERFLNPARIS MPDFDIDFDE 430 440 450 460 470 480 RRRGEVIDYV TKKYGSDHVA QIVTFATIKA KQALKDSARV LSYPYSFGER LTKAMPPAVM 490 500 510 520 530 540 GREIPLRAIF DTTHSRHREA SEVRQMIESD YEMQQIFNTA KGLENLKRQW AVHAAGVIMS 550 560 570 580 590 600 DAPIIDIIPI MKRESDGHIV TQFDYASCES LGLVKMDFLG LRNLTIIDDA LANIRQNKNT 610 620 630 640 650 660 KVDLENLPLD DPEVYKLLRR ADTLGVFQLD SGPIRQLLEL MQPDSFDDIS AAIALYRPGP 670 680 690 700 710 720 MGARSHTNYA LRKNRKQEID HIHPELTKDL SVLLSSTYGL IVYQEQVIGI AQKLAGFTLE 730 740 750 760 770 780 EADVLRWAMG KKKKDELDRQ YNKFANGMRK AGYSDGATEA LWNVLLPFSD YAFNKAHATA 790 800 810 820 830 840 YGLISYWTAY LKAHYPTEYM AALLTSVETS RDKLGLYLQE CRHMCIKVLL PDINVSRSGF 850 860 870 880 890 900 TPSGENILFG LGAIKNVGAN LIDDILEVRE DGPFVSLIDF VQRMPHSVLN RRSVMSLIQA 910 920 930 940 950 960 GAFDSIHPNR RSLMDIHRSV LENCQANARR SDVSLLDGLL DEYEGFSPPD IPDWNNRERL 970 980 990 1000 1010 1020 KYEREMLGMY VSSHPLDGLE DSLLKFRDCS IAECISRKPQ DVIRVAGLIT SVEHKVARRT 1030 1040 1050 1060 1070 1080 GMRYAHAILE DTSGEIQIML SGQNYNNFSE QLVTDSIVSV TGRISFRDDA TTLYCDSIKD 1090 1100 1110 1120 1130 1140 VLPVKKEARL RLKCSEGFLT QNVFIALDDV LRKYPGDTPV TMEVIITDNS VVKSKTFELS 1150 1160 RCVEISNDLI AEVKGILGVE GISG

References

[1]

"Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei." Bentley S.D., Maiwald M., Murphy L.D., Pallen M.J., Yeats C.A., Dover L.G., Norbertczak H.T., Besra G.S., Quail M.A., Harris D.E., von Herbay A., Goble A., Rutter S., Squares R., Squares S., Barrell B.G., Parkhill J., Relman D.A. Lancet 361:637-644(2003) [PubMed: 12606174] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX251410 Genomic DNA. Translation: CAD66928.1.
RefSeq	NP_789191.1. NC_004551.1.
3D structure databases
ProteinModelPortal	Q83I40.
ModBase	Search...
Protein-protein interaction databases
STRING	Q83I40.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1064543.
GenomeReviews	Gene locus TW252 in contig BX072543_GR.
KEGG	tws:TW252.
PATRIC	23998943. VBITroWhi42739_0312.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0587.
HOGENOM	HBG734490.
OMA	RVLQMPY.
PhylomeDB	Q83I40.
ProtClustDB	PRK05673.
Enzyme and pathway databases
BioCyc	TWHI218496:TW0236-MONOMER.
Family and domain databases
InterPro	IPR011708. DNA_pol3_alpha. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K02337.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q83I40_TROW8

Accession

Primary (citable) accession number: Q83I40

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	December 14, 2011
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)