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Q83I29

- Q83I29_TROW8

UniProt

Q83I29 - Q83I29_TROW8

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Protein
Alanine racemase
Gene
alr1, TW266
Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei42 – 421Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei150 – 1501Substrate By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alr1Imported
Ordered Locus Names:TW266Imported
OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)Imported
Taxonomic identifieri218496 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000001413: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi218496.TW266.

Structurei

3D structure databases

ProteinModelPortaliQ83I29.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
KOiK01775.
OMAiGHTWTAQ.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SUPFAMiSSF51419. SSF51419. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83I29-1 [UniParc]FASTAAdd to Basket

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MTQRTALSNS HAQAFISLGT LKKNLLWLQN EVAPAKVFMV IKANANGHGT    50
MRVAEVAKMS GIRNFAVLLP KEALLIKRAL SPGVRVFTWH ITPDCEDLPS 100
LIENNIEIGI GAEWQLRYIA SCVKKTMTCE VLSGYKPALI HLKLDTGLSR 150
GGCGVKDWQN LVCLAQDFQE MGLIKITGFW SHLSNTSPEE DRRSLKIFTE 200
NVTPYLASYS RRARPIMHIA ASVAALGLPE SRLDYVRLGL SCFGYYEKEE 250
LKGVMTLVAP IIKFLPEQGR AIIACGFADG ISPLAVRNNV PLTGRSNRAR 300
LIEVGPETSV IEICQDIDRR QDNLQNSYDH VPQDPFLNAL RVSQNHVILF 350
GSGGLSELTA RQWAESCGTT IDDVLSRVKA ELIYLE 386
Length:386
Mass (Da):42,749
Last modified:June 1, 2003 - v1
Checksum:iA0EF49AD65F731F1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX251410 Genomic DNA. Translation: CAD66942.1.
RefSeqiNP_789205.1. NC_004551.1.
WP_011096223.1. NC_004551.1.

Genome annotation databases

EnsemblBacteriaiCAD66942; CAD66942; TW266.
GeneIDi1064557.
KEGGitws:TW266.
PATRICi23998975. VBITroWhi42739_0327.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX251410 Genomic DNA. Translation: CAD66942.1 .
RefSeqi NP_789205.1. NC_004551.1.
WP_011096223.1. NC_004551.1.

3D structure databases

ProteinModelPortali Q83I29.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218496.TW266.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD66942 ; CAD66942 ; TW266 .
GeneIDi 1064557.
KEGGi tws:TW266.
PATRICi 23998975. VBITroWhi42739_0327.

Phylogenomic databases

eggNOGi COG0787.
KOi K01775.
OMAi GHTWTAQ.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SUPFAMi SSF51419. SSF51419. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW08/27.

Entry informationi

Entry nameiQ83I29_TROW8
AccessioniPrimary (citable) accession number: Q83I29
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi