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Q83I29

- Q83I29_TROW8

UniProt

Q83I29 - Q83I29_TROW8

Protein

Alanine racemase

Gene

alr1

Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei42 – 421Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei150 – 1501SubstrateUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alr1Imported
    Ordered Locus Names:TW266Imported
    OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)Imported
    Taxonomic identifieri218496 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
    ProteomesiUP000001413: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei42 – 421N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi218496.TW266.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83I29.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    KOiK01775.
    OMAiGHTWTAQ.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SUPFAMiSSF51419. SSF51419. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q83I29-1 [UniParc]FASTAAdd to Basket

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    MTQRTALSNS HAQAFISLGT LKKNLLWLQN EVAPAKVFMV IKANANGHGT    50
    MRVAEVAKMS GIRNFAVLLP KEALLIKRAL SPGVRVFTWH ITPDCEDLPS 100
    LIENNIEIGI GAEWQLRYIA SCVKKTMTCE VLSGYKPALI HLKLDTGLSR 150
    GGCGVKDWQN LVCLAQDFQE MGLIKITGFW SHLSNTSPEE DRRSLKIFTE 200
    NVTPYLASYS RRARPIMHIA ASVAALGLPE SRLDYVRLGL SCFGYYEKEE 250
    LKGVMTLVAP IIKFLPEQGR AIIACGFADG ISPLAVRNNV PLTGRSNRAR 300
    LIEVGPETSV IEICQDIDRR QDNLQNSYDH VPQDPFLNAL RVSQNHVILF 350
    GSGGLSELTA RQWAESCGTT IDDVLSRVKA ELIYLE 386
    Length:386
    Mass (Da):42,749
    Last modified:June 1, 2003 - v1
    Checksum:iA0EF49AD65F731F1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX251410 Genomic DNA. Translation: CAD66942.1.
    RefSeqiNP_789205.1. NC_004551.1.
    WP_011096223.1. NC_004551.1.

    Genome annotation databases

    EnsemblBacteriaiCAD66942; CAD66942; TW266.
    GeneIDi1064557.
    KEGGitws:TW266.
    PATRICi23998975. VBITroWhi42739_0327.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX251410 Genomic DNA. Translation: CAD66942.1 .
    RefSeqi NP_789205.1. NC_004551.1.
    WP_011096223.1. NC_004551.1.

    3D structure databases

    ProteinModelPortali Q83I29.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218496.TW266.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD66942 ; CAD66942 ; TW266 .
    GeneIDi 1064557.
    KEGGi tws:TW266.
    PATRICi 23998975. VBITroWhi42739_0327.

    Phylogenomic databases

    eggNOGi COG0787.
    KOi K01775.
    OMAi GHTWTAQ.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .

    Family and domain databases

    Gene3Di 3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR001608. Ala_racemase_N.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SUPFAMi SSF51419. SSF51419. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW08/27Imported.

    Entry informationi

    Entry nameiQ83I29_TROW8
    AccessioniPrimary (citable) accession number: Q83I29
    Entry historyi
    Integrated into UniProtKB/TrEMBL: June 1, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3