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Q83HV5

- SYL_TROW8

UniProt

Q83HV5 - SYL_TROW8

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei574 – 5741ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:TW385
    OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
    Taxonomic identifieri218496 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
    ProteomesiUP000001413: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 806806Leucine--tRNA ligasePRO_0000152110Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi218496.TW385.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83HV5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi54 – 6411"HIGH" regionAdd
    BLAST
    Motifi571 – 5755"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200747.
    KOiK01869.
    OMAiVNIVTND.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83HV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHALRALDTL CENMEYNFRA LEEKWAPIWE RDRLFEVDEN DSETPRKYVL    50
    DMFSYPSGDL HMGHAETYAY GDFIARYWRH RGYNVLHPVG WDSFGLPAEN 100
    AAIKHGSDPK VWTYRNIDQQ ARSMRLYAAS FDWSRRLHTS DPEYYRWNQW 150
    LFLKLYKHGL AYRKKAWVNW DPSDRTVLAN EQVLPDGTSE RSGALVVKKK 200
    LTQWFLRITA YADRLLDDLS MLENNWPERV ITMQRNWIGR SEGVSIEFNI 250
    PTLKRPVMVF TTRPETIFGV TYLALAFDSE VTEELASKSG VLGELLELRH 300
    NIDKTHESVR GLDLKSFAIH PLTGQSIPIF AASYILSDYA KGAVMSVPGH 350
    DTRDERFAVR YNLPIVKIME DNRLISSGKY SGQSVTQARE NITRDLCAKS 400
    LGRREISYRL RDWLISRQRY WGTPIPILYD SNGSEIPVEE DDLPVLLPDS 450
    EGIDLTPSGL SPLGGIHDWV NLHKAGSLFR RDTDTMDTFF DSSWYFLRYL 500
    NPDCDTAPFT LEKAKKWGPV DQYCGGVEHA VLHLLYARFI TKFLYDIGFV 550
    DFKEPFLRLI NQGMVVLNGA KMSKSKGNIV EFSKEVSQHG VDVIRFALIF 600
    SGPPEEDIDW KDVSMTGAAR FLSRCIQTAK EVPKRTADLS LGDIELRKHT 650
    HSLLNDIDWL VDSYRFNVIA ARLMDLLNIT RKKIQTIGAD NPAIREAIET 700
    IAIALDMFSP YTAEEMWEIL GNKYSVSKAL FPEVDTTFLE QKTTCAIVQI 750
    DGRLRGRLNV LTNITTEQLV HSARSLPAIE HALSGRSVKR VICVPPKLVN 800
    FVVEPK 806
    Length:806
    Mass (Da):92,374
    Last modified:June 1, 2003 - v1
    Checksum:i0A85A3718E1609F2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX251411 Genomic DNA. Translation: CAD67056.1.
    RefSeqiNP_789318.1. NC_004551.1.

    Genome annotation databases

    EnsemblBacteriaiCAD67056; CAD67056; TW385.
    GeneIDi1064671.
    KEGGitws:TW385.
    PATRICi23999241. VBITroWhi42739_0450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX251411 Genomic DNA. Translation: CAD67056.1 .
    RefSeqi NP_789318.1. NC_004551.1.

    3D structure databases

    ProteinModelPortali Q83HV5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218496.TW385.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD67056 ; CAD67056 ; TW385 .
    GeneIDi 1064671.
    KEGGi tws:TW385.
    PATRICi 23999241. VBITroWhi42739_0450.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200747.
    KOi K01869.
    OMAi VNIVTND.
    OrthoDBi EOG63Z74X.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW08/27.

    Entry informationi

    Entry nameiSYL_TROW8
    AccessioniPrimary (citable) accession number: Q83HV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3