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Q83HQ7

- UPPP_TROW8

UniProt

Q83HQ7 - UPPP_TROW8

Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

    Catalytic activityi

    Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

    GO - Molecular functioni

    1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. dephosphorylation Source: InterPro
    2. peptidoglycan biosynthetic process Source: UniProtKB-KW
    3. regulation of cell shape Source: UniProtKB-KW
    4. response to antibiotic Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
    Alternative name(s):
    Bacitracin resistance proteinUniRule annotation
    Undecaprenyl pyrophosphate phosphataseUniRule annotation
    Gene namesi
    Name:uppPUniRule annotation
    Synonyms:bacA, upk
    Ordered Locus Names:TW457
    OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
    Taxonomic identifieri218496 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
    ProteomesiUP000001413: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 279279Undecaprenyl-diphosphatasePRO_0000151232Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi218496.TW457.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalUniRule annotationAdd
    BLAST
    Transmembranei39 – 5921HelicalUniRule annotationAdd
    BLAST
    Transmembranei96 – 11621HelicalUniRule annotationAdd
    BLAST
    Transmembranei128 – 14821HelicalUniRule annotationAdd
    BLAST
    Transmembranei155 – 17521HelicalUniRule annotationAdd
    BLAST
    Transmembranei201 – 22121HelicalUniRule annotationAdd
    BLAST
    Transmembranei231 – 25121HelicalUniRule annotationAdd
    BLAST
    Transmembranei259 – 27921HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UppP family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1968.
    HOGENOMiHOG000218357.
    KOiK06153.
    OMAiFNDAHAK.
    OrthoDBiEOG6QP13M.

    Family and domain databases

    HAMAPiMF_01006. Undec_diphosphatase.
    InterProiIPR003824. UppP.
    [Graphical view]
    PfamiPF02673. BacA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83HQ7-1 [UniParc]FASTAAdd to Basket

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    MVLEAVLLGI VQGITEFLPI SSTAHMYILA KLLNLHVPGR FFLSSVQLGT    50
    SFALILYFFK DVKGIISETS RSIYSFIQFG IRQKQEKRNE YTRLGLLLVT 100
    GTIPVVLLGF LLVRFVPDGF FSAARNLFTM GVALIVFGLL LGFADALFRR 150
    KKGNIFQITF IESVLIGAAQ IFAIIPGVSR SGITITTARF LNFDRQLAVR 200
    FSFLLSLPVT FIGGMYGLVA GPDTDYYSLG YSLIGAIVSF VVGLLVVSAL 250
    LRIISKTTFV LFVYYRVLFG LFLVIVSFF 279
    Length:279
    Mass (Da):30,898
    Last modified:June 1, 2003 - v1
    Checksum:i6F92D079885A91C1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX251411 Genomic DNA. Translation: CAD67125.1.
    RefSeqiNP_789387.1. NC_004551.1.
    WP_011096405.1. NC_004551.1.

    Genome annotation databases

    EnsemblBacteriaiCAD67125; CAD67125; TW457.
    GeneIDi1064298.
    KEGGitws:TW457.
    PATRICi23999395. VBITroWhi42739_0524.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX251411 Genomic DNA. Translation: CAD67125.1 .
    RefSeqi NP_789387.1. NC_004551.1.
    WP_011096405.1. NC_004551.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218496.TW457.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD67125 ; CAD67125 ; TW457 .
    GeneIDi 1064298.
    KEGGi tws:TW457.
    PATRICi 23999395. VBITroWhi42739_0524.

    Phylogenomic databases

    eggNOGi COG1968.
    HOGENOMi HOG000218357.
    KOi K06153.
    OMAi FNDAHAK.
    OrthoDBi EOG6QP13M.

    Family and domain databases

    HAMAPi MF_01006. Undec_diphosphatase.
    InterProi IPR003824. UppP.
    [Graphical view ]
    Pfami PF02673. BacA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW08/27.

    Entry informationi

    Entry nameiUPPP_TROW8
    AccessioniPrimary (citable) accession number: Q83HQ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3