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Q83HQ3

- DEF_TROW8

UniProt

Q83HQ3 - DEF_TROW8

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Protein

Peptide deformylase

Gene

def

Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi114 – 1141IronUniRule annotation
Metal bindingi156 – 1561IronUniRule annotation
Active sitei157 – 1571UniRule annotation
Metal bindingi160 – 1601IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:TW462
OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Taxonomic identifieri218496 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000001413: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 201201Peptide deformylasePRO_0000082870Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi218496.TW462.

Structurei

3D structure databases

ProteinModelPortaliQ83HQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243508.
KOiK01462.
OMAiQQANNST.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83HQ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKISGGKIL PIYITGHAVL HAPAKPVTDF SGIQEIVRDM FATMFAAPGV
60 70 80 90 100
GLAGPQIGLG LRIFVYSYTE GDTLHQGVAI NPDLLIPKGV PKRQTHKQQA
110 120 130 140 150
NNSTSCDEPD REGCLSFPGY QFPLERAPQV TLSAFDENKK PFTVHATGWL
160 170 180 190 200
ARIFQHEFDH LQGTLYVDRL AQKYSGEVRQ AVLNNKWGIP GKYWVPQEPK

E
Length:201
Mass (Da):22,282
Last modified:June 1, 2003 - v1
Checksum:i63F9A0A930850A4F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX251411 Genomic DNA. Translation: CAD67130.1.
RefSeqiNP_789392.1. NC_004551.1.
WP_011096410.1. NC_004551.1.

Genome annotation databases

EnsemblBacteriaiCAD67130; CAD67130; TW462.
GeneIDi1064303.
KEGGitws:TW462.
PATRICi23999409. VBITroWhi42739_0530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX251411 Genomic DNA. Translation: CAD67130.1 .
RefSeqi NP_789392.1. NC_004551.1.
WP_011096410.1. NC_004551.1.

3D structure databases

ProteinModelPortali Q83HQ3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218496.TW462.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD67130 ; CAD67130 ; TW462 .
GeneIDi 1064303.
KEGGi tws:TW462.
PATRICi 23999409. VBITroWhi42739_0530.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243508.
KOi K01462.
OMAi QQANNST.
OrthoDBi EOG664CMF.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW08/27.

Entry informationi

Entry nameiDEF_TROW8
AccessioniPrimary (citable) accession number: Q83HQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3