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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei120SubstrateUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Binding sitei208ATPUniRule annotation1
Binding sitei296ATP; via carbonyl oxygenUniRule annotation1
Binding sitei327ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi353 – 356ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:TW471
OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Taxonomic identifieri218496 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesTropheryma

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001460311 – 395Phosphoglycerate kinaseAdd BLAST395

Proteomic databases

PRIDEiQ83HP8

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ83HP8
SMRiQ83HP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 22Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit

Sequencei

Sequence statusi: Complete.

Q83HP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTLGGFTFP CDAPVFVRVD FNVPMDEVGT ITDDLRIRAS LPTIESLLGR
60 70 80 90 100
GAPLILISHL GRPVKNEQQG FSLKPCAERL SEYIGVNVPL VDFLDLDTKL
110 120 130 140 150
YGELTRHLDK SGIVLFENIR FFAEETSKAQ ADRRILAEQL APFAGAYVND
160 170 180 190 200
AFGASHRRHA SVYELAQAFS NKAAGFLIES EMQAFSHLAS EAKRPYTVIL
210 220 230 240 250
GGAKLSDKLR LIENILPTVD RLLLCGGMAF TFLAAQGCET GKSLLEESFI
260 270 280 290 300
SEANKIIDFA KQNNVELILP VDVIEARSLT SPLGVVSKAE SISYMGLDIG
310 320 330 340 350
PETQSIFRNV IQDSKTVFWN GPAGLFENPS FSNGTRALLD ALSSSSAFTF
360 370 380 390
IGGGDTAAAV SLLGFDYGDF SHVSTGGGAC LELLEGKILP ALEVL
Length:395
Mass (Da):42,679
Last modified:June 1, 2003 - v1
Checksum:iFE3D38502096E016
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX251411 Genomic DNA Translation: CAD67138.1
RefSeqiWP_011096418.1, NC_004551.1

Genome annotation databases

EnsemblBacteriaiCAD67138; CAD67138; TW471
KEGGitws:TW471

Similar proteinsi

Entry informationi

Entry nameiPGK_TROW8
AccessioniPrimary (citable) accession number: Q83HP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health