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Q83HP8

- PGK_TROW8

UniProt

Q83HP8 - PGK_TROW8

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361SubstrateUniRule annotation
    Binding sitei120 – 1201SubstrateUniRule annotation
    Binding sitei157 – 1571SubstrateUniRule annotation
    Binding sitei208 – 2081ATPUniRule annotation
    Binding sitei296 – 2961ATP; via carbonyl oxygenUniRule annotation
    Binding sitei327 – 3271ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi353 – 3564ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:TW471
    OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
    Taxonomic identifieri218496 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
    ProteomesiUP000001413: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395Phosphoglycerate kinasePRO_0000146031Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi218496.TW471.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83HP8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 223Substrate bindingUniRule annotation
    Regioni59 – 624Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227107.
    KOiK00927.
    OMAiAGHPVGK.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q83HP8-1 [UniParc]FASTAAdd to Basket

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    MRTLGGFTFP CDAPVFVRVD FNVPMDEVGT ITDDLRIRAS LPTIESLLGR    50
    GAPLILISHL GRPVKNEQQG FSLKPCAERL SEYIGVNVPL VDFLDLDTKL 100
    YGELTRHLDK SGIVLFENIR FFAEETSKAQ ADRRILAEQL APFAGAYVND 150
    AFGASHRRHA SVYELAQAFS NKAAGFLIES EMQAFSHLAS EAKRPYTVIL 200
    GGAKLSDKLR LIENILPTVD RLLLCGGMAF TFLAAQGCET GKSLLEESFI 250
    SEANKIIDFA KQNNVELILP VDVIEARSLT SPLGVVSKAE SISYMGLDIG 300
    PETQSIFRNV IQDSKTVFWN GPAGLFENPS FSNGTRALLD ALSSSSAFTF 350
    IGGGDTAAAV SLLGFDYGDF SHVSTGGGAC LELLEGKILP ALEVL 395
    Length:395
    Mass (Da):42,679
    Last modified:June 1, 2003 - v1
    Checksum:iFE3D38502096E016
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX251411 Genomic DNA. Translation: CAD67138.1.
    RefSeqiNP_789400.1. NC_004551.1.

    Genome annotation databases

    EnsemblBacteriaiCAD67138; CAD67138; TW471.
    GeneIDi1064311.
    KEGGitws:TW471.
    PATRICi23999427. VBITroWhi42739_0539.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BX251411 Genomic DNA. Translation: CAD67138.1 .
    RefSeqi NP_789400.1. NC_004551.1.

    3D structure databases

    ProteinModelPortali Q83HP8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 218496.TW471.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAD67138 ; CAD67138 ; TW471 .
    GeneIDi 1064311.
    KEGGi tws:TW471.
    PATRICi 23999427. VBITroWhi42739_0539.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227107.
    KOi K00927.
    OMAi AGHPVGK.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: TW08/27.

    Entry informationi

    Entry nameiPGK_TROW8
    AccessioniPrimary (citable) accession number: Q83HP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3