Q83HK8 (Q83HK8_TROW8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dihydroorotate dehydrogenase EMBL CAD67199.1
EC=1.3.3.1 EMBL CAD67199.1

Gene names

Name:	pyrD EMBL CAD67199.1
Ordered Locus Names:	TW532

Organism

Tropheryma whipplei (strain TW08/27) (Whipple's bacillus) [Complete proteome] [HAMAP]

Taxonomic identifier

218496 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length	330 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor By similarity. SAAS SAAS012135
Catalytic activity	(S)-dihydroorotate + a quinone = orotate + a quinol. SAAS SAAS012135
Cofactor	Binds 1 FMN per subunit By similarity. SAAS SAAS012135
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. SAAS SAAS012135
Subunit structure	Monomer By similarity. SAAS SAAS012135

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis SAAS SAAS012135
Cellular component	Membrane SAAS SAAS012135
Ligand	FMN SAAS SAAS012135 Flavoprotein SAAS SAAS012135
Molecular function	Oxidoreductase SAAS SAAS012135 EMBL CAD67199.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro UMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	dihydroorotate oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	170	1	Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

	Sequence		Length	Mass (Da)
	Q83HK8 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: EF3B7273EE3A4C69	FASTA	330	36,422
	10 20 30 40 50 60 MNFLKCVDPE LAHRIAAVAL KSGLGMFVPQ RFHIHLGTTS MGLYFDTPLG IAAGFDKFAD 70 80 90 100 110 120 LVIPLYSLGF GHVEVGTVTL HPQPGNKKPR IHRVMSQKAL INSMGFNNPG AQKMRENILK 130 140 150 160 170 180 VRKSGRRLPI IGVNIGKSKV CPLEESAKDY VKSFELLADV SDYLVINVSS PNTEGLRTLQ 190 200 210 220 230 240 SVGNLNKILR SVKPIADRFK RPVLIKISPD LSNSDVTNIA LLVKEFGLAG VVASNTTTKR 250 260 270 280 290 300 TGLPNEFSSL HGGLSGPMLK ERSLEMLKIL RRDLPKNKFC IISVGGVWDY TDVLERLEYG 310 320 330 ADLVQGYTAF VYNGPYWASN INRDLSRLRS

References

[1]

"Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei." Bentley S.D., Maiwald M., Murphy L.D., Pallen M.J., Yeats C.A., Dover L.G., Norbertczak H.T., Besra G.S., Quail M.A., Harris D.E., von Herbay A., Goble A., Rutter S., Squares R., Squares S., Barrell B.G., Parkhill J., Relman D.A. Lancet 361:637-644(2003) [PubMed: 12606174] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX251411 Genomic DNA. Translation: CAD67199.1.
RefSeq	NP_789461.1. NC_004551.1.
3D structure databases
HSSP	HSSP built from PDB template 1D3G based on UniProtKB Q02127.
ProteinModelPortal	Q83HK8.
ModBase	Search...
Protein-protein interaction databases
STRING	Q83HK8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1064736.
GenomeReviews	Gene locus TW532 in contig BX072543_GR.
KEGG	tws:TW532.
PATRIC	23999563. VBITroWhi42739_0603.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0167.
HOGENOM	HBG351027.
OMA	SYVTVNI.
PhylomeDB	Q83HK8.
ProtClustDB	PRK05286.
Enzyme and pathway databases
BioCyc	TWHI218496:TW0506-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR012135. Dihydroorotate_DH_1_2. IPR005719. Dihydroorotate_DH_2. IPR001295. Dihydroorotate_DH_CS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00226.
Pfam	PF01180. DHO_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMs	TIGR01036. PyrD_sub2. 1 hit.
PROSITE	PS00911. DHODEHASE_1. 1 hit. PS00912. DHODEHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q83HK8_TROW8

Accession

Primary (citable) accession number: Q83HK8

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)