Q83HG9 (Q83HG9_TROW8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative methionine synthase EMBL CAD67274.1
EC=2.1.1.14 EMBL CAD67274.1

Gene names

Name:	metT EMBL CAD67274.1
Ordered Locus Names:	TW610

Organism

Tropheryma whipplei (strain TW08/27) (Whipple's bacillus) [Complete proteome] [HAMAP]

Taxonomic identifier

218496 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length	822 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. SAAS SAAS013215
Catalytic activity	5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. SAAS SAAS013215
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. SAAS SAAS013215

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Methionine biosynthesis SAAS SAAS013215
Ligand	Metal-binding SAAS SAAS013215 Zinc SAAS SAAS013215
Molecular function	Methyltransferase SAAS SAAS013215 EMBL CAD67274.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q83HG9 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 8E9BF93A0A04E666	FASTA	822	91,676
	10 20 30 40 50 60 MLFGTILGYP RLGPRRELRD YLYSYWQGKI SEEVLEEKTR LLREETHRRL ILLGLSAENY 70 80 90 100 110 120 SIPESFSYYD HVLDAAVHVG AVPSRFSWLL NDGIVDLNAY FTLARGDRSL APLESLRYFG 130 140 150 160 170 180 SSYHYLVPEI DGNTHFALTS HRVITQFEQA KQAGVNVRPT ILGPVSLLMM SRSHGPNAIN 190 200 210 220 230 240 PIERLQDLVP VYSELFEKLY NSGCKFVQVD EPAVTHNTFG IQKSQELLVD AYKFLSSRKL 250 260 270 280 290 300 RPEILVAMSY GNAADQVDAL ATTGVEAMAF NLIDGAVPFA NPSLADKALF GGVIDGRNIW 310 320 330 340 350 360 RGDLAAAYYK LERLRELSGN VVASTSASLF HLPLSLDTED LGDHLKEWLA FADEKVRQVM 370 380 390 400 410 420 ILARGLEYGV GCIYEHLDSA ANSLSDRMTT PGVRVEEVRQ ALQDLGESDF CRPPREQQQG 430 440 450 460 470 480 CNHASLPILP MVGIGEFSDG TPFVNNDGIP NNNPQAAISF QEDLDILAVQ RLGDIDPIQR 490 500 510 520 530 540 FASRMHGFAI THNGWVQSIG PHSVCPPILW GDVSRITPMS SWIEYTQTLT EKSVKPVLPG 550 560 570 580 590 600 PLTLLMSCFV REDQPFQETA QQIAIAIRDD IADLQRSGIR AIQIDEPALE EFLSIYDNAR 610 620 630 640 650 660 YCAPQVFRLA TSSAKPEVQI HLHLRPPNLV ETIDIINDLD ADVISAEIVP YTFGLPAQKC 670 680 690 700 710 720 LMEIRRRIPL CLYFHDANFS RMPSVDECRY LIDTLVRDVD GATLAKQFDD MHIAGFTAGC 730 740 750 760 770 780 AFTAINPRDI CVPRADDAGI PSLGSGADHT LERQKATYIP GGIHNLWIGL IYSHSGYNAF 790 800 810 820 VYDSAYMRDI YIGNELQFVK NMTQAVLLLR KEFTSPQKAL SA

References

[1]

"Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei." Bentley S.D., Maiwald M., Murphy L.D., Pallen M.J., Yeats C.A., Dover L.G., Norbertczak H.T., Besra G.S., Quail M.A., Harris D.E., von Herbay A., Goble A., Rutter S., Squares R., Squares S., Barrell B.G., Parkhill J., Relman D.A. Lancet 361:637-644(2003) [PubMed: 12606174] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX251412 Genomic DNA. Translation: CAD67274.1.
RefSeq	NP_789536.1. NC_004551.1.
3D structure databases
ProteinModelPortal	Q83HG9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q83HG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1064815.
GenomeReviews	Gene locus TW610 in contig BX072543_GR.
KEGG	tws:TW610.
PATRIC	23999867. VBITroWhi42739_0751.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0620.
HOGENOM	HBG287495.
OMA	RNIWRAN.
PhylomeDB	Q83HG9.
ProtClustDB	PRK05222.
Enzyme and pathway databases
BioCyc	TWHI218496:TW0581-MONOMER.
Family and domain databases
InterPro	IPR013215. Cbl-indep_Met_Synth_N. IPR002629. Methionine_synth. [Graphical view]
KO	K00549.
Pfam	PF08267. Meth_synt_1. 1 hit. PF01717. Meth_synt_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q83HG9_TROW8

Accession

Primary (citable) accession number: Q83HG9

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	December 14, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)