Q83HE7 (Q83HE7_TROW8) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Aminomethyltransferase RuleBase RU003981
EC=2.1.2.10 RuleBase RU003981

Gene names

Name:	gcvT EMBL CAD67319.1
Ordered Locus Names:	TW659

Organism

Tropheryma whipplei (strain TW08/27) (Whipple's bacillus) [Complete proteome] [HAMAP]

Taxonomic identifier

218496 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. RuleBase RU003981
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. SAAS SAAS006223 RuleBase RU003981
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity. RuleBase RU003981
Sequence similarities	Belongs to the GcvT family. RuleBase RU003980

Ontologies

Keywords
Molecular function	Aminotransferase SAAS SAAS006223 RuleBase RU003981 Methyltransferase EMBL CAD67319.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q83HE7 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 4486872668FFB2B5	FASTA	356	39,134
	10 20 30 40 50 60 MAMTRVSPLD NEHKALGAIF TCFAGYKLPV RYKSDIAEHT AVRQGCGIFD LSHMAEIFVS 70 80 90 100 110 120 GVNAGLELDI ALTGHFSDMT CGRAKYTLIL NEQGGIEDDL IVYRIDDKNY MVVANAINRK 130 140 150 160 170 180 KVFSLLRDRV HTSDIKDETD SISLVAVQGP ESESLIRDLF HESGNLRYFS HRCYPHGGTD 190 200 210 220 230 240 RSEKLSCSIV ARTGYTGEDG FEIFTPNDSV VSIWRALIER GATPCGLAAR NTLRIEAGMP 250 260 270 280 290 300 LYGHELRADL NPVQAGLERF ISPPCIGCDR INHSGDFPLL VGLSIDGRRA AREGYTIYSS 310 320 330 340 350 SNIPVGTVTS GCFSPTLGCS IAMAYVKAKA RSAQLYIDIR GSMTPCKVVP MPFYRR

References

[1]

"Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei." Bentley S.D., Maiwald M., Murphy L.D., Pallen M.J., Yeats C.A., Dover L.G., Norbertczak H.T., Besra G.S., Quail M.A., Harris D.E., von Herbay A., Goble A., Rutter S., Squares R., Squares S., Barrell B.G., Parkhill J., Relman D.A. Lancet 361:637-644(2003) [PubMed: 12606174] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX251412 Genomic DNA. Translation: CAD67319.1.
RefSeq	NP_789581.1. NC_004551.1.
3D structure databases
ProteinModelPortal	Q83HE7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q83HE7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1064860.
GenomeReviews	Gene locus TW659 in contig BX072543_GR.
KEGG	tws:TW659.
PATRIC	23999989. VBITroWhi42739_0805.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	KALYGGM.
PhylomeDB	Q83HE7.
ProtClustDB	CLSK230190.
Enzyme and pathway databases
BioCyc	TWHI218496:TW0626-MONOMER.
Family and domain databases
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q83HE7_TROW8

Accession

Primary (citable) accession number: Q83HE7

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	December 14, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)