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Q83HC3

- SYW_TROW8

UniProt

Q83HC3 - SYW_TROW8

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Protein

Tryptophan--tRNA ligase

Gene
trpS, TW705
Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei204 – 2041ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Ordered Locus Names:TW705
OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Taxonomic identifieri218496 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000001413: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Tryptophan--tRNA ligaseUniRule annotationPRO_0000136702Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi218496.TW705.

Structurei

3D structure databases

ProteinModelPortaliQ83HC3.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi20 – 2910"HIGH" regionUniRule annotation
Motifi201 – 2055"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059940.
KOiK01867.
OMAiIDPKKHI.
OrthoDBiEOG686NJQ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83HC3-1 [UniParc]FASTAAdd to Basket

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MTSSAIRINK KPVVLSGIQP SSGMLHLGNY LGALKSFGRM QDDYTTYFML    50
ANLHSMTFPQ NPEVLRENTI RIAAQCIAAG IDPAKSIVFL QSDVYQHNQL 100
AWVLGNVCTF GEAARMTQFK DKSGKQGNIS TGLFTYPILM ASDILLYDSA 150
FVPVGADQKQ HLELTRTLAR RFNAQYGQTF LVPQPFECSI RIYDLQDPAV 200
KMSKSSATES GTIFLLDSPD KIVKKIMRSV TDSEDVIGYD RETKPGVSNL 250
VVMYSCLTDC TIEQTVNIYS GKKYSVLKKD LSDILVEVCT TIATRTNELL 300
DDKNYIRKIL VTASEQARGV AQKTIDRVYE KLGVY 335
Length:335
Mass (Da):37,339
Last modified:June 1, 2003 - v1
Checksum:iB1AFF6CD1983BE4D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX251412 Genomic DNA. Translation: CAD67364.1.
RefSeqiNP_789626.1. NC_004551.1.
WP_011096642.1. NC_004551.1.

Genome annotation databases

EnsemblBacteriaiCAD67364; CAD67364; TW705.
GeneIDi1064905.
KEGGitws:TW705.
PATRICi24000093. VBITroWhi42739_0856.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX251412 Genomic DNA. Translation: CAD67364.1 .
RefSeqi NP_789626.1. NC_004551.1.
WP_011096642.1. NC_004551.1.

3D structure databases

ProteinModelPortali Q83HC3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218496.TW705.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD67364 ; CAD67364 ; TW705 .
GeneIDi 1064905.
KEGGi tws:TW705.
PATRICi 24000093. VBITroWhi42739_0856.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000059940.
KOi K01867.
OMAi IDPKKHI.
OrthoDBi EOG686NJQ.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW08/27.

Entry informationi

Entry nameiSYW_TROW8
AccessioniPrimary (citable) accession number: Q83HC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi