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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei204 – 2041ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:TW705
OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Taxonomic identifieri218496 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000001413 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Tryptophan--tRNA ligasePRO_0000136702Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi218496.TW705.

Structurei

3D structure databases

ProteinModelPortaliQ83HC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi20 – 2910"HIGH" region
Motifi201 – 2055"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059940.
KOiK01867.
OMAiGWGQFKP.
OrthoDBiEOG686NJQ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83HC3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSAIRINK KPVVLSGIQP SSGMLHLGNY LGALKSFGRM QDDYTTYFML
60 70 80 90 100
ANLHSMTFPQ NPEVLRENTI RIAAQCIAAG IDPAKSIVFL QSDVYQHNQL
110 120 130 140 150
AWVLGNVCTF GEAARMTQFK DKSGKQGNIS TGLFTYPILM ASDILLYDSA
160 170 180 190 200
FVPVGADQKQ HLELTRTLAR RFNAQYGQTF LVPQPFECSI RIYDLQDPAV
210 220 230 240 250
KMSKSSATES GTIFLLDSPD KIVKKIMRSV TDSEDVIGYD RETKPGVSNL
260 270 280 290 300
VVMYSCLTDC TIEQTVNIYS GKKYSVLKKD LSDILVEVCT TIATRTNELL
310 320 330
DDKNYIRKIL VTASEQARGV AQKTIDRVYE KLGVY
Length:335
Mass (Da):37,339
Last modified:May 31, 2003 - v1
Checksum:iB1AFF6CD1983BE4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX251412 Genomic DNA. Translation: CAD67364.1.
RefSeqiNP_789626.1. NC_004551.1.

Genome annotation databases

KEGGitws:TW705.
PATRICi24000093. VBITroWhi42739_0856.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX251412 Genomic DNA. Translation: CAD67364.1.
RefSeqiNP_789626.1. NC_004551.1.

3D structure databases

ProteinModelPortaliQ83HC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi218496.TW705.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGitws:TW705.
PATRICi24000093. VBITroWhi42739_0856.

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000059940.
KOiK01867.
OMAiGWGQFKP.
OrthoDBiEOG686NJQ.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW08/27.

Entry informationi

Entry nameiSYW_TROW8
AccessioniPrimary (citable) accession number: Q83HC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2003
Last sequence update: May 31, 2003
Last modified: March 31, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.