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Protein

UDP-N-acetylenolpyruvoylglucosamine reductase

Gene

murB

Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotation

Catalytic activityi

UDP-N-acetyl-alpha-D-muramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei158UniRule annotation1
Active sitei239Proton donorUniRule annotation1
Active sitei343UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis
LigandFAD, Flavoprotein, NADP

Enzyme and pathway databases

UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylenolpyruvoylglucosamine reductaseUniRule annotation (EC:1.3.1.98UniRule annotation)
Alternative name(s):
UDP-N-acetylmuramate dehydrogenaseUniRule annotation
Gene namesi
Name:murBUniRule annotation
Ordered Locus Names:TW734
OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Taxonomic identifieri218496 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesTropheryma

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001792831 – 351UDP-N-acetylenolpyruvoylglucosamine reductaseAdd BLAST351

Structurei

3D structure databases

ProteinModelPortaliQ83HA7
SMRiQ83HA7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 213FAD-binding PCMH-typeUniRule annotationAdd BLAST203

Sequence similaritiesi

Belongs to the MurB family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000284356
KOiK00075
OMAiAWLIDKA
OrthoDBiPOG091H02K7

Family and domain databases

Gene3Di3.30.43.10, 1 hit
3.90.78.10, 1 hit
HAMAPiMF_00037 MurB, 1 hit
InterProiView protein in InterPro
IPR016166 FAD-bd_2
IPR036318 FAD-bd_2-like_sf
IPR016167 FAD-bd_2_sub1
IPR003170 MurB
IPR011601 MurB_C
IPR036635 MurB_C_sf
IPR006094 Oxid_FAD_bind_N
PANTHERiPTHR21071 PTHR21071, 1 hit
PfamiView protein in Pfam
PF01565 FAD_binding_4, 1 hit
PF02873 MurB_C, 1 hit
SUPFAMiSSF56176 SSF56176, 1 hit
SSF56194 SSF56194, 1 hit
PROSITEiView protein in PROSITE
PS51387 FAD_PCMH, 1 hit

Sequencei

Sequence statusi: Complete.

Q83HA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSFSEITTL GVGGSIACFI ECSPDEFVER APGLFRPGHH VLVVGGGSNL
60 70 80 90 100
VASDCPFPGT VVRLKSRDTI ISDDGNYTRF SVSAGTSWDD LVSYTLDLGF
110 120 130 140 150
DQLSPMSGIP GTFGGALAQN ISAYGAAVRD VLGSVEVYDA CTSEVVTFGL
160 170 180 190 200
EDMRYGYRTS ALKNVRNKVI LGGTLLLKPG PTPVLYRQLA NALKVDLGTY
210 220 230 240 250
CSGKQVRDQV LRIRAEKGML PRYLVPKGFD VCNTSSVGSF FVNPIVSKEH
260 270 280 290 300
LSRLRRLVPQ GALNSSVIQT DEMGGVKVSA AFLLEQSGFE KGFCISGSQA
310 320 330 340 350
AISTQHSLAI VNRGGATAAE VIELAGLITR TVSRKFDIHL IPEPVFVGLE

L
Length:351
Mass (Da):37,447
Last modified:June 1, 2003 - v1
Checksum:iBBCDF8DAD413C1B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX251412 Genomic DNA Translation: CAD67393.1
RefSeqiWP_011096671.1, NC_004551.1

Genome annotation databases

EnsemblBacteriaiCAD67393; CAD67393; TW734
KEGGitws:TW734

Similar proteinsi

Entry informationi

Entry nameiMURB_TROW8
AccessioniPrimary (citable) accession number: Q83HA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

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