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Q83HA3 (Q83HA3_TROW8) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase RuleBase RU004370
EC=6.3.3.1 RuleBase RU004370
Gene names
Name:purM EMBL CAD67397.1
Ordered Locus Names:TW738
OrganismTropheryma whipplei (strain TW08/27) (Whipple's bacillus) [Complete proteome] [HAMAP]
Taxonomic identifier218496 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length337 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. RuleBase RU004370 SAAS SAAS004733

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. RuleBase RU004371 SAAS SAAS004733

Subcellular location

Cytoplasm By similarity SAAS SAAS004733.

Sequence similarities

Belongs to the AIR synthase family. RuleBase RU004370

Sequences

Sequence LengthMass (Da)Tools
Q83HA3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 028C17B54BE038A3

FASTA33735,779
        10         20         30         40         50         60 
MMDPYAAAGV DIVAGQLAVE AMRHAVEATH NSRVPEGLGG FAGLFDISFL KRYRSPLLVT 

        70         80         90        100        110        120 
STDGVGTKVV IAQELDKHDT IGQDLVAMVV GDIAVVGGKP LFMTDYIACG ELIPERIAQI 

       130        140        150        160        170        180 
VGGVARACQE IDCVLLGGET AEHPEVMARN QYDLAGAATG VVEASDLLGK DKVKTGDVLI 

       190        200        210        220        230        240 
GVASSGLHAN GFSLVRKICR DVSFAEYCPD LQTTWGEALL EPTRMYVNLI RDLIKTGKLH 

       250        260        270        280        290        300 
AASHITGGGI PGNLPRILPE GLGARLHPWP IPDLFKVLCE FGSLSLSEVK NAWNLGIGLI 

       310        320        330 
IVASSTSILE DIDDSWQARL IGEVIDGEAI QWTGSLS

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References

[1]"Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei."
Bentley S.D., Maiwald M., Murphy L.D., Pallen M.J., Yeats C.A., Dover L.G., Norbertczak H.T., Besra G.S., Quail M.A., Harris D.E., von Herbay A., Goble A., Rutter S., Squares R., Squares S., Barrell B.G., Parkhill J., Relman D.A.
Lancet 361:637-644(2003) [PubMed: 12606174] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BX251412 Genomic DNA. Translation: CAD67397.1.
RefSeqNP_789659.1. NC_004551.1.

3D structure databases

HSSPHSSP built from PDB template 1CLI based on UniProtKB P08178.
ProteinModelPortalQ83HA3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ83HA3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1064938.
GenomeReviewsGene locus TW738 in contig BX072543_GR.
KEGGtws:TW738.
PATRIC24000183. VBITroWhi42739_0898.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0150.
HOGENOMHBG531222.
OMAPENIPRV.
PhylomeDBQ83HA3.
ProtClustDBPRK05385.

Enzyme and pathway databases

BioCycTWHI218496:TW0704-MONOMER.

Family and domain databases

InterProIPR000728. AIR_synth.
IPR010918. AIR_synth_C.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
KOK01933.
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF56042. AIR_synth_C. 1 hit.
SSF55326. PurM_N-like. 1 hit.
TIGRFAMsTIGR00878. PurM. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ83HA3_TROW8
AccessionPrimary (citable) accession number: Q83HA3
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: December 14, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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