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Q83H98

- GSA_TROW8

UniProt

Q83H98 - GSA_TROW8

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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Tropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
Ordered Locus Names:TW743
OrganismiTropheryma whipplei (strain TW08/27) (Whipple's bacillus)
Taxonomic identifieri218496 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000001413: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Glutamate-1-semialdehyde 2,1-aminomutasePRO_0000243640Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei292 – 2921N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi218496.TW743.

Structurei

3D structure databases

ProteinModelPortaliQ83H98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0001.
HOGENOMiHOG000020210.
KOiK01845.
OMAiRAIKPYP.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83H98-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTNFEWFEE AKRFIPGGVN SPVRAYAAVG GTPRFLAKAQ GAYVTDIEGR
60 70 80 90 100
EYVDLVSSWG PLILGHAHPK VIDAVINTAH RGMSYGAPTT LEVELAELVC
110 120 130 140 150
NRICNAQGIK PVERLRLVST GTESCMTAIR LARCFTGRDL IVKFSGHYHG
160 170 180 190 200
HADPFLIDAG SGLVGHPSSG GVPESVAKNT LVVPYNDLAV LEYLFEAYPN
210 220 230 240 250
QIACIITEAC PANMGVIPPD PGFNARVADL GHSHGALIIF DEVITGFRVG
260 270 280 290 300
SGGFWALETS LASQQPTQAV SEGSVSDSAY SAYVPDLFTF AKVLGGGLPI
310 320 330 340 350
GAIGGRAEIM DLLSPSGPVY QAGTLSGNPL ATAAGLATLR LADSNIYEHM
360 370 380 390 400
NRVARALINE IQSAFHDAGV PCTVQSAGNL FGISFSAIAP RDFTQATSQE
410 420 430 440 450
HWRYSNFFHS MLNSGVLLPP SVYEAWFVSA AFDDRAIERV VNALPDAVRA
460
AGSAPARPKG FEPPTF
Length:466
Mass (Da):49,582
Last modified:June 1, 2003 - v1
Checksum:i76A75C29AE74C473
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX251412 Genomic DNA. Translation: CAD67402.1.
RefSeqiNP_789664.1. NC_004551.1.
WP_011096680.1. NC_004551.1.

Genome annotation databases

EnsemblBacteriaiCAD67402; CAD67402; TW743.
GeneIDi1064943.
KEGGitws:TW743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BX251412 Genomic DNA. Translation: CAD67402.1 .
RefSeqi NP_789664.1. NC_004551.1.
WP_011096680.1. NC_004551.1.

3D structure databases

ProteinModelPortali Q83H98.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 218496.TW743.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAD67402 ; CAD67402 ; TW743 .
GeneIDi 1064943.
KEGGi tws:TW743.

Phylogenomic databases

eggNOGi COG0001.
HOGENOMi HOG000020210.
KOi K01845.
OMAi RAIKPYP.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TW08/27.

Entry informationi

Entry nameiGSA_TROW8
AccessioniPrimary (citable) accession number: Q83H98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3