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Q83GX6

- NADK_TROWT

UniProt

Q83GX6 - NADK_TROWT

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Protein

NAD kinase

Gene

nadK

Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Proton acceptorUniRule annotation
Binding sitei89 – 891NADUniRule annotation
Binding sitei169 – 1691NADUniRule annotation
Binding sitei188 – 1881NADUniRule annotation
Binding sitei258 – 2581NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi84 – 852NADUniRule annotation
Nucleotide bindingi158 – 1592NADUniRule annotation
Nucleotide bindingi199 – 2046NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciTWHI203267:GJDK-109-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:TWT_103
OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
Taxonomic identifieri203267 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000002200: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301NAD kinasePRO_0000120683Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203267.TWT103.

Structurei

3D structure databases

ProteinModelPortaliQ83GX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiGVLWCDG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83GX6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRVYIAHNGC LEAEPIYGTI CELVAQRKMS VITDPHARNN ESARNTDSGV
60 70 80 90 100
VSLNQAGRNK YLDQETTSRS INVPFCAGIS IGGDGTFLRM ARDLKNTGTP
110 120 130 140 150
LFGVNMGRMG FLVDIEPEDI VNLVENIVKG EYTEEKRLPI TASVQRGGKK
160 170 180 190 200
IHDEWAVNEI TIERKVEGKV VDIEVFVDGC RVMDISCNGI IIATATGSTA
210 220 230 240 250
YSFSSGGPIV WPEMKVTLVV PVSPHELFAK PIVLPDNRSI LLKVTSRDNK
260 270 280 290 300
VVLCSDGQVR LCLQSGDEIA CHVGKVPVVF GRVKKGCFAE HLVKKFNLQT

A
Length:301
Mass (Da):32,917
Last modified:June 1, 2003 - v1
Checksum:iE44153CD31FEBB99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014184 Genomic DNA. Translation: AAO44200.1.
RefSeqiNP_787231.1. NC_004572.3.
WP_011102352.1. NC_004572.3.

Genome annotation databases

EnsemblBacteriaiAAO44200; AAO44200; TWT_103.
GeneIDi1482364.
KEGGitwh:TWT103.
PATRICi23996481. VBITroWhi72342_0133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014184 Genomic DNA. Translation: AAO44200.1 .
RefSeqi NP_787231.1. NC_004572.3.
WP_011102352.1. NC_004572.3.

3D structure databases

ProteinModelPortali Q83GX6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203267.TWT103.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO44200 ; AAO44200 ; TWT_103 .
GeneIDi 1482364.
KEGGi twh:TWT103.
PATRICi 23996481. VBITroWhi72342_0133.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi GVLWCDG.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci TWHI203267:GJDK-109-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
    Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
    Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Twist.

Entry informationi

Entry nameiNADK_TROWT
AccessioniPrimary (citable) accession number: Q83GX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2003
Last modified: November 26, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3