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Q83GX6 (NADK_TROWT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:TWT_103
OrganismTropheryma whipplei (strain Twist) (Whipple's bacillus) [Complete proteome] [HAMAP]
Taxonomic identifier203267 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301NAD kinase HAMAP-Rule MF_00361
PRO_0000120683

Regions

Nucleotide binding84 – 852NAD By similarity
Nucleotide binding158 – 1592NAD By similarity
Nucleotide binding199 – 2046NAD By similarity

Sites

Active site841Proton acceptor By similarity
Binding site891NAD By similarity
Binding site1691NAD By similarity
Binding site1881NAD By similarity
Binding site2581NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83GX6 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: E44153CD31FEBB99

FASTA30132,917
        10         20         30         40         50         60 
MRVYIAHNGC LEAEPIYGTI CELVAQRKMS VITDPHARNN ESARNTDSGV VSLNQAGRNK 

        70         80         90        100        110        120 
YLDQETTSRS INVPFCAGIS IGGDGTFLRM ARDLKNTGTP LFGVNMGRMG FLVDIEPEDI 

       130        140        150        160        170        180 
VNLVENIVKG EYTEEKRLPI TASVQRGGKK IHDEWAVNEI TIERKVEGKV VDIEVFVDGC 

       190        200        210        220        230        240 
RVMDISCNGI IIATATGSTA YSFSSGGPIV WPEMKVTLVV PVSPHELFAK PIVLPDNRSI 

       250        260        270        280        290        300 
LLKVTSRDNK VVLCSDGQVR LCLQSGDEIA CHVGKVPVVF GRVKKGCFAE HLVKKFNLQT 


A 

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References

[1]"Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Twist.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014184 Genomic DNA. Translation: AAO44200.1.
RefSeqNP_787231.1. NC_004572.3.

3D structure databases

ProteinModelPortalQ83GX6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING203267.TWT103.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO44200; AAO44200; TWT_103.
GeneID1482364.
KEGGtwh:TWT103.
PATRIC23996481. VBITroWhi72342_0133.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
KOK00858.
OMAGVLWCDG.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycTWHI203267:GJDK-109-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_TROWT
AccessionPrimary (citable) accession number: Q83GX6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: June 1, 2003
Last modified: July 9, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families