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Q83GV1

- GCSP_TROWT

UniProt

Q83GV1 - GCSP_TROWT

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, gcvB, TWT_135
Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTWHI203267:GJDK-142-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Synonyms:gcvB
Ordered Locus Names:TWT_135
OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
Taxonomic identifieri203267 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000002200: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 968968Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000166944Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei717 – 7171N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi203267.TWT135.

Structurei

3D structure databases

ProteinModelPortaliQ83GV1.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiSAVEMEP.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83GV1-1 [UniParc]FASTAAdd to Basket

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MHERHIGPSQ EEIDHMLGFL GYKSLDDLMN AALPNGVQSP PDIKIPSHDE    50
LTCLTQLAAY AKMNRIKTSM LGQGFYNCIT PAVIRRNILE NPSWYTSYTP 100
YQPEISQGRL EMLINFQTMI CDLTGLEIAN ASMLDEASCA AEAMLLAKRV 150
SRSSSNKYLV HNGVFPHIRR VLETRADAVG VEIVDLPEGQ SIDFDHFGVY 200
AQYQSASGKL LDLRHLFSRS KRAGAICVIG CDLLMLTLFT SPGELGADIA 250
FGSAQRFGIP MNFGGPLASF LAARKAMERS LPGRLVGVSV DADSNHAYRL 300
TLQTREQHIR REKATSNICT ATVLMAIAAV AFAQHHGPKG LRAIAHRINT 350
VAVGFARLLK QTAFRVSSLD IFDTIEINNP TQLCVEAESK HDLLFWKVDD 400
NKLRITFDEV TARLDGDLPE RLSKVFGISP DKIRDLGCNY DSCDCSFYSD 450
SQQAREGLSS VASRNISVHS DLARHPLRRF SGYLKHPVFN NYTGEVALMR 500
YLKALSDKDF ALDRGMIPLG SCTMKLNAAF QLEPVLWPEF ANLHPFAPRG 550
DADGTLQIID QIETWLANLS GYDAVSLQPT AGSQGELAGL LAIRGYYKSL 600
NLDRDVCLIP ASAHGTNAAS AVLAGMRVVV VACDQQGNID LDDLRLKASK 650
NAHALAALMV TYPSTHGVYE DNISEVCSVV HKYGGQVYVD GANSNALIGY 700
LRTGDFGGDV SHLNLHKTFG IPHGGGGPGI GPVVAKAHLA PFLPFRNRVH 750
KPSTDLPAVK HMGGPIASSD YGFAGALYIS WAYIFCLGSQ GMKRCTAVAV 800
LVANYIAKQL SDTFPVLYTG KNNLVAHEFI MDFREVTRVS GITVDDVCKR 850
LIDYGFHAPT MSFPVPGTLM VEPTESEPFS EIQRFIKTIR SIRAEIDRVI 900
DKTYDPDNNP LKRAPHTLEQ IASDKWDRPY SRRTGIVYTS GKYWPASARI 950
DNAYGDRNIF CTCPDLPD 968
Length:968
Mass (Da):106,422
Last modified:June 1, 2003 - v1
Checksum:i822D3C136DDC71B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014184 Genomic DNA. Translation: AAO44232.1.
RefSeqiNP_787263.1. NC_004572.3.
WP_011102376.1. NC_004572.3.

Genome annotation databases

EnsemblBacteriaiAAO44232; AAO44232; TWT_135.
GeneIDi1482397.
KEGGitwh:TWT135.
PATRICi23996551. VBITroWhi72342_0167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014184 Genomic DNA. Translation: AAO44232.1 .
RefSeqi NP_787263.1. NC_004572.3.
WP_011102376.1. NC_004572.3.

3D structure databases

ProteinModelPortali Q83GV1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203267.TWT135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO44232 ; AAO44232 ; TWT_135 .
GeneIDi 1482397.
KEGGi twh:TWT135.
PATRICi 23996551. VBITroWhi72342_0167.

Phylogenomic databases

eggNOGi COG1003.
KOi K00281.
OMAi SAVEMEP.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci TWHI203267:GJDK-142-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
    Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
    Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Twist.

Entry informationi

Entry nameiGCSP_TROWT
AccessioniPrimary (citable) accession number: Q83GV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: September 3, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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