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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTWHI203267:GJDK-142-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Synonyms:gcvB
Ordered Locus Names:TWT_135
OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
Taxonomic identifieri203267 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesTropheryma
ProteomesiUP000002200 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 968968Glycine dehydrogenase (decarboxylating)PRO_0000166944Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei717 – 7171N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi203267.TWT135.

Structurei

3D structure databases

ProteinModelPortaliQ83GV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83GV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHERHIGPSQ EEIDHMLGFL GYKSLDDLMN AALPNGVQSP PDIKIPSHDE
60 70 80 90 100
LTCLTQLAAY AKMNRIKTSM LGQGFYNCIT PAVIRRNILE NPSWYTSYTP
110 120 130 140 150
YQPEISQGRL EMLINFQTMI CDLTGLEIAN ASMLDEASCA AEAMLLAKRV
160 170 180 190 200
SRSSSNKYLV HNGVFPHIRR VLETRADAVG VEIVDLPEGQ SIDFDHFGVY
210 220 230 240 250
AQYQSASGKL LDLRHLFSRS KRAGAICVIG CDLLMLTLFT SPGELGADIA
260 270 280 290 300
FGSAQRFGIP MNFGGPLASF LAARKAMERS LPGRLVGVSV DADSNHAYRL
310 320 330 340 350
TLQTREQHIR REKATSNICT ATVLMAIAAV AFAQHHGPKG LRAIAHRINT
360 370 380 390 400
VAVGFARLLK QTAFRVSSLD IFDTIEINNP TQLCVEAESK HDLLFWKVDD
410 420 430 440 450
NKLRITFDEV TARLDGDLPE RLSKVFGISP DKIRDLGCNY DSCDCSFYSD
460 470 480 490 500
SQQAREGLSS VASRNISVHS DLARHPLRRF SGYLKHPVFN NYTGEVALMR
510 520 530 540 550
YLKALSDKDF ALDRGMIPLG SCTMKLNAAF QLEPVLWPEF ANLHPFAPRG
560 570 580 590 600
DADGTLQIID QIETWLANLS GYDAVSLQPT AGSQGELAGL LAIRGYYKSL
610 620 630 640 650
NLDRDVCLIP ASAHGTNAAS AVLAGMRVVV VACDQQGNID LDDLRLKASK
660 670 680 690 700
NAHALAALMV TYPSTHGVYE DNISEVCSVV HKYGGQVYVD GANSNALIGY
710 720 730 740 750
LRTGDFGGDV SHLNLHKTFG IPHGGGGPGI GPVVAKAHLA PFLPFRNRVH
760 770 780 790 800
KPSTDLPAVK HMGGPIASSD YGFAGALYIS WAYIFCLGSQ GMKRCTAVAV
810 820 830 840 850
LVANYIAKQL SDTFPVLYTG KNNLVAHEFI MDFREVTRVS GITVDDVCKR
860 870 880 890 900
LIDYGFHAPT MSFPVPGTLM VEPTESEPFS EIQRFIKTIR SIRAEIDRVI
910 920 930 940 950
DKTYDPDNNP LKRAPHTLEQ IASDKWDRPY SRRTGIVYTS GKYWPASARI
960
DNAYGDRNIF CTCPDLPD
Length:968
Mass (Da):106,422
Last modified:June 1, 2003 - v1
Checksum:i822D3C136DDC71B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014184 Genomic DNA. Translation: AAO44232.1.
RefSeqiWP_011102376.1. NC_004572.3.

Genome annotation databases

EnsemblBacteriaiAAO44232; AAO44232; TWT_135.
KEGGitwh:TWT135.
PATRICi23996551. VBITroWhi72342_0167.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014184 Genomic DNA. Translation: AAO44232.1.
RefSeqiWP_011102376.1. NC_004572.3.

3D structure databases

ProteinModelPortaliQ83GV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi203267.TWT135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO44232; AAO44232; TWT_135.
KEGGitwh:TWT135.
PATRICi23996551. VBITroWhi72342_0167.

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiMAGMYAV.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciTWHI203267:GJDK-142-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
    Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
    Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Twist.

Entry informationi

Entry nameiGCSP_TROWT
AccessioniPrimary (citable) accession number: Q83GV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: July 22, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.