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Q83GV1

- GCSP_TROWT

UniProt

Q83GV1 - GCSP_TROWT

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciTWHI203267:GJDK-142-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Synonyms:gcvB
    Ordered Locus Names:TWT_135
    OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
    Taxonomic identifieri203267 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
    ProteomesiUP000002200: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 968968Glycine dehydrogenase (decarboxylating)PRO_0000166944Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei717 – 7171N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi203267.TWT135.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83GV1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    KOiK00281.
    OMAiSAVEMEP.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q83GV1-1 [UniParc]FASTAAdd to Basket

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    MHERHIGPSQ EEIDHMLGFL GYKSLDDLMN AALPNGVQSP PDIKIPSHDE    50
    LTCLTQLAAY AKMNRIKTSM LGQGFYNCIT PAVIRRNILE NPSWYTSYTP 100
    YQPEISQGRL EMLINFQTMI CDLTGLEIAN ASMLDEASCA AEAMLLAKRV 150
    SRSSSNKYLV HNGVFPHIRR VLETRADAVG VEIVDLPEGQ SIDFDHFGVY 200
    AQYQSASGKL LDLRHLFSRS KRAGAICVIG CDLLMLTLFT SPGELGADIA 250
    FGSAQRFGIP MNFGGPLASF LAARKAMERS LPGRLVGVSV DADSNHAYRL 300
    TLQTREQHIR REKATSNICT ATVLMAIAAV AFAQHHGPKG LRAIAHRINT 350
    VAVGFARLLK QTAFRVSSLD IFDTIEINNP TQLCVEAESK HDLLFWKVDD 400
    NKLRITFDEV TARLDGDLPE RLSKVFGISP DKIRDLGCNY DSCDCSFYSD 450
    SQQAREGLSS VASRNISVHS DLARHPLRRF SGYLKHPVFN NYTGEVALMR 500
    YLKALSDKDF ALDRGMIPLG SCTMKLNAAF QLEPVLWPEF ANLHPFAPRG 550
    DADGTLQIID QIETWLANLS GYDAVSLQPT AGSQGELAGL LAIRGYYKSL 600
    NLDRDVCLIP ASAHGTNAAS AVLAGMRVVV VACDQQGNID LDDLRLKASK 650
    NAHALAALMV TYPSTHGVYE DNISEVCSVV HKYGGQVYVD GANSNALIGY 700
    LRTGDFGGDV SHLNLHKTFG IPHGGGGPGI GPVVAKAHLA PFLPFRNRVH 750
    KPSTDLPAVK HMGGPIASSD YGFAGALYIS WAYIFCLGSQ GMKRCTAVAV 800
    LVANYIAKQL SDTFPVLYTG KNNLVAHEFI MDFREVTRVS GITVDDVCKR 850
    LIDYGFHAPT MSFPVPGTLM VEPTESEPFS EIQRFIKTIR SIRAEIDRVI 900
    DKTYDPDNNP LKRAPHTLEQ IASDKWDRPY SRRTGIVYTS GKYWPASARI 950
    DNAYGDRNIF CTCPDLPD 968
    Length:968
    Mass (Da):106,422
    Last modified:June 1, 2003 - v1
    Checksum:i822D3C136DDC71B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014184 Genomic DNA. Translation: AAO44232.1.
    RefSeqiNP_787263.1. NC_004572.3.
    WP_011102376.1. NC_004572.3.

    Genome annotation databases

    EnsemblBacteriaiAAO44232; AAO44232; TWT_135.
    GeneIDi1482397.
    KEGGitwh:TWT135.
    PATRICi23996551. VBITroWhi72342_0167.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014184 Genomic DNA. Translation: AAO44232.1 .
    RefSeqi NP_787263.1. NC_004572.3.
    WP_011102376.1. NC_004572.3.

    3D structure databases

    ProteinModelPortali Q83GV1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203267.TWT135.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO44232 ; AAO44232 ; TWT_135 .
    GeneIDi 1482397.
    KEGGi twh:TWT135.
    PATRICi 23996551. VBITroWhi72342_0167.

    Phylogenomic databases

    eggNOGi COG1003.
    KOi K00281.
    OMAi SAVEMEP.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci TWHI203267:GJDK-142-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
      Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
      Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Twist.

    Entry informationi

    Entry nameiGCSP_TROWT
    AccessioniPrimary (citable) accession number: Q83GV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3