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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciTWHI203267:G1FZY-152-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Synonyms:gcvB
Ordered Locus Names:TWT_135
OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
Taxonomic identifieri203267 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesTropheryma
Proteomesi
  • UP000002200 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669441 – 968Glycine dehydrogenase (decarboxylating)Add BLAST968

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei717N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ83GV1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi203267.TWT135

Structurei

3D structure databases

ProteinModelPortaliQ83GV1
SMRiQ83GV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PF02347 GDC-P, 1 hit
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

Q83GV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHERHIGPSQ EEIDHMLGFL GYKSLDDLMN AALPNGVQSP PDIKIPSHDE
60 70 80 90 100
LTCLTQLAAY AKMNRIKTSM LGQGFYNCIT PAVIRRNILE NPSWYTSYTP
110 120 130 140 150
YQPEISQGRL EMLINFQTMI CDLTGLEIAN ASMLDEASCA AEAMLLAKRV
160 170 180 190 200
SRSSSNKYLV HNGVFPHIRR VLETRADAVG VEIVDLPEGQ SIDFDHFGVY
210 220 230 240 250
AQYQSASGKL LDLRHLFSRS KRAGAICVIG CDLLMLTLFT SPGELGADIA
260 270 280 290 300
FGSAQRFGIP MNFGGPLASF LAARKAMERS LPGRLVGVSV DADSNHAYRL
310 320 330 340 350
TLQTREQHIR REKATSNICT ATVLMAIAAV AFAQHHGPKG LRAIAHRINT
360 370 380 390 400
VAVGFARLLK QTAFRVSSLD IFDTIEINNP TQLCVEAESK HDLLFWKVDD
410 420 430 440 450
NKLRITFDEV TARLDGDLPE RLSKVFGISP DKIRDLGCNY DSCDCSFYSD
460 470 480 490 500
SQQAREGLSS VASRNISVHS DLARHPLRRF SGYLKHPVFN NYTGEVALMR
510 520 530 540 550
YLKALSDKDF ALDRGMIPLG SCTMKLNAAF QLEPVLWPEF ANLHPFAPRG
560 570 580 590 600
DADGTLQIID QIETWLANLS GYDAVSLQPT AGSQGELAGL LAIRGYYKSL
610 620 630 640 650
NLDRDVCLIP ASAHGTNAAS AVLAGMRVVV VACDQQGNID LDDLRLKASK
660 670 680 690 700
NAHALAALMV TYPSTHGVYE DNISEVCSVV HKYGGQVYVD GANSNALIGY
710 720 730 740 750
LRTGDFGGDV SHLNLHKTFG IPHGGGGPGI GPVVAKAHLA PFLPFRNRVH
760 770 780 790 800
KPSTDLPAVK HMGGPIASSD YGFAGALYIS WAYIFCLGSQ GMKRCTAVAV
810 820 830 840 850
LVANYIAKQL SDTFPVLYTG KNNLVAHEFI MDFREVTRVS GITVDDVCKR
860 870 880 890 900
LIDYGFHAPT MSFPVPGTLM VEPTESEPFS EIQRFIKTIR SIRAEIDRVI
910 920 930 940 950
DKTYDPDNNP LKRAPHTLEQ IASDKWDRPY SRRTGIVYTS GKYWPASARI
960
DNAYGDRNIF CTCPDLPD
Length:968
Mass (Da):106,422
Last modified:June 1, 2003 - v1
Checksum:i822D3C136DDC71B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014184 Genomic DNA Translation: AAO44232.1
RefSeqiWP_011102376.1, NC_004572.3

Genome annotation databases

EnsemblBacteriaiAAO44232; AAO44232; TWT_135
GeneIDi29578187
KEGGitwh:TWT_135

Similar proteinsi

Entry informationi

Entry nameiGCSP_TROWT
AccessioniPrimary (citable) accession number: Q83GV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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