Q83GT4 (Q83GT4_TROWT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase EMBL AAO44259.1
EC=2.1.1.14 EMBL AAO44259.1

Gene names

Name:	metE EMBL AAO44259.1
Ordered Locus Names:	TWT162
ORF Names:	TWT_162 EMBL AAO44259.1

Organism

Tropheryma whipplei (strain Twist) (Whipple's bacillus) [Complete proteome] [HAMAP]

Taxonomic identifier

203267 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length	822 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. SAAS SAAS013215
Catalytic activity	5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. SAAS SAAS013215
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. SAAS SAAS013215

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Methionine biosynthesis SAAS SAAS013215
Ligand	Metal-binding SAAS SAAS013215 Zinc SAAS SAAS013215
Molecular function	Methyltransferase SAAS SAAS013215 EMBL AAO44259.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q83GT4 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 1192FF2A0C0BDBDE	FASTA	822	91,674
	10 20 30 40 50 60 MLFGTILGYP RLGPRRELRD YLYSYWQGKI SEEVLEEKTR LLREETHRRL ILLGLSAENY 70 80 90 100 110 120 SIPESFSYYD HVLDAAVHVG AVPSRFSWLL NDGIVDLNAY FTLARGDRSL APLESLRYFG 130 140 150 160 170 180 SSYHYLVPEI DGNTHFALTS HRVITQFEQA KQAGVNVRPT ILGPVSLLMM SRSHGPNAIN 190 200 210 220 230 240 PIERLQDLVP VYSELFEKLY NSGCKFVQVD EPAVTHNTFG IQKSQELLVD AYKFLSSRKL 250 260 270 280 290 300 RPEILVAMSY GNAADQVDAL ATTGVEAMAF NLIDGAVPFA NPSLADKALF GGVIDGRNIW 310 320 330 340 350 360 RGDLAAAYYK LERLRELSGN VVASTSASLF HLPLSLDTED LGDHLKEWLA FADEKVRQVM 370 380 390 400 410 420 ILARGLEYGV GCIYEHLDSA ANSLSDRMTT PGVRVEEVRQ ALQDLGESDF CRPPREQQQG 430 440 450 460 470 480 CNHASLPILP MVGIGEFSDG TPFVNNDGIP NNNPQAAISF QEDLDILAVQ RLGDIDPIQR 490 500 510 520 530 540 FASRMHGFAI THNGWVQSIG PHSVCPPILW GDVSRITPMS SWIEYTQTLT EKSVKPVLPG 550 560 570 580 590 600 PLTLLMSCFV REDQPFQETA QQIAIAIRDD IADLQRSGIR AIQIDEPALE EFLSIYDNAR 610 620 630 640 650 660 YCAPQVFRLA TSSAKPEVQI HLHLRPPNLV ETIDIINDLD VDVISAEIVP YTFGLPAQKC 670 680 690 700 710 720 LMEIRRRIPL CLYFHDANFS RMPSVDECRY LIDTLVRDVD GATLAKQFDD MHIAGFTAGC 730 740 750 760 770 780 AFTAINPRDI CVPRADDAGI PSLGSGADHA LERQKATYIP GGIHNLWIGL IYSHSGYNAF 790 800 810 820 VYDSAYMRDI YIGNELQFVK NMTQAVLLLR KEFTSPQKAL SA

References

[1]	"Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome." Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M. Genome Res. 13:1800-1809(2003) [PubMed: 12902375] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014184 Genomic DNA. Translation: AAO44259.1.
RefSeq	NP_787290.1. NC_004572.3.
3D structure databases
ProteinModelPortal	Q83GT4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q83GT4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1482427.
GenomeReviews	Gene locus TWT162 in contig AE014184_GR.
KEGG	twh:TWT162.
PATRIC	23996661. VBITroWhi72342_0219.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0620.
HOGENOM	HBG287495.
OMA	RNIWRAN.
PhylomeDB	Q83GT4.
ProtClustDB	PRK05222.
Enzyme and pathway databases
BioCyc	TWHI203267:TW162-MONOMER.
Family and domain databases
InterPro	IPR013215. Cbl-indep_Met_Synth_N. IPR002629. Methionine_synth. [Graphical view]
KO	K00549.
Pfam	PF08267. Meth_synt_1. 1 hit. PF01717. Meth_synt_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q83GT4_TROWT

Accession

Primary (citable) accession number: Q83GT4

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	December 14, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)