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Q83GP4

- SYE_TROWT

UniProt

Q83GP4 - SYE_TROWT

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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei258 – 2581ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTWHI203267:GJDK-224-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Synonyms:gltS
Ordered Locus Names:TWT_209
OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
Taxonomic identifieri203267 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000002200: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 480480Glutamate--tRNA ligasePRO_0000119689Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi203267.TWT209.

Structurei

3D structure databases

ProteinModelPortaliQ83GP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi12 – 2211"HIGH" regionAdd
BLAST
Motifi255 – 2595"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
KOiK01885.
OMAiPEGMLNY.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83GP4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRDPRVRVRF CPSPTGAPHL GLVRTALFNW VFARKHGGGF IFRIEDTDAT
60 70 80 90 100
RNREESCSQL IDTLKWLGLD WDEGPDKGGQ FGPYYQSQRG DIYQEVLDKL
110 120 130 140 150
LAADLAYESF STKEEIEKRN LEAGRPIQLG YDNYDRTLSE QTKAAMREAG
160 170 180 190 200
RTPIIRLRMD DENIAFEDLV KGEVVFTDPI PDFALTRASG EPLYTLVNPV
210 220 230 240 250
DDAFMKITHV LRGEDLLSST PRQIALYKAL ITIGITDYVP FFGHLPIVMG
260 270 280 290 300
EGNRKLSKRN PESDFYFYKA RGFIREGLLN YLSLLGWSIS NSRDTFSLSE
310 320 330 340 350
MIHAFDVRDV RGNPARFDYK KCLAINAYHL RELNVEDFFL RLVPFVEEML
360 370 380 390 400
GIPLSFEQKN SLRAICPFVQ GRVQLLTEAA EMVRFLLVDN ISVDFAVTDK
410 420 430 440 450
EIDVLRHCLA LLNLLDTWES AQIASCIKQA IEQFDLQPKR IFSILRLAIT
460 470 480
GRRVSPPLFE SMQILGRSAS LNRVETFVTN
Length:480
Mass (Da):54,801
Last modified:June 1, 2003 - v1
Checksum:i798470EDC1A71F42
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014184 Genomic DNA. Translation: AAO44306.1.
RefSeqiNP_787337.1. NC_004572.3.
WP_011096509.1. NC_004572.3.

Genome annotation databases

EnsemblBacteriaiAAO44306; AAO44306; TWT_209.
GeneIDi1482479.
KEGGitwh:TWT209.
PATRICi23996903. VBITroWhi72342_0336.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014184 Genomic DNA. Translation: AAO44306.1 .
RefSeqi NP_787337.1. NC_004572.3.
WP_011096509.1. NC_004572.3.

3D structure databases

ProteinModelPortali Q83GP4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203267.TWT209.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO44306 ; AAO44306 ; TWT_209 .
GeneIDi 1482479.
KEGGi twh:TWT209.
PATRICi 23996903. VBITroWhi72342_0336.

Phylogenomic databases

eggNOGi COG0008.
KOi K01885.
OMAi PEGMLNY.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci TWHI203267:GJDK-224-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
    Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
    Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Twist.

Entry informationi

Entry nameiSYE_TROWT
AccessioniPrimary (citable) accession number: Q83GP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3