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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciTWHI203267:G1FZY-281-MONOMER
UniPathwayiUPA00219

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:TWT_224
OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
Taxonomic identifieri203267 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesTropheryma
Proteomesi
  • UP000002200 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2 – 22HelicalUniRule annotationAdd BLAST21
Transmembranei54 – 74HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21
Transmembranei113 – 133HelicalUniRule annotationAdd BLAST21
Transmembranei158 – 178HelicalUniRule annotationAdd BLAST21
Transmembranei195 – 215HelicalUniRule annotationAdd BLAST21
Transmembranei241 – 261HelicalUniRule annotationAdd BLAST21
Transmembranei268 – 288HelicalUniRule annotationAdd BLAST21
Transmembranei293 – 313HelicalUniRule annotationAdd BLAST21
Transmembranei347 – 367HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001089211 – 369Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST369

Interactioni

Protein-protein interaction databases

STRINGi203267.TWT224

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY Bacteria
COG0472 LUCA
KOiK01000
OMAiLMSPLHH
OrthoDBiPOG091H00VH

Family and domain databases

CDDicd06852 GT_MraY, 1 hit
HAMAPiMF_00038 MraY, 1 hit
InterProiView protein in InterPro
IPR000715 Glycosyl_transferase_4
IPR003524 PNAcMuramoyl-5peptid_Trfase
IPR018480 PNAcMuramoyl-5peptid_Trfase_CS
PANTHERiPTHR22926 PTHR22926, 1 hit
PfamiView protein in Pfam
PF00953 Glycos_transf_4, 1 hit
PF10555 MraY_sig1, 1 hit
TIGRFAMsiTIGR00445 mraY, 1 hit
PROSITEiView protein in PROSITE
PS01347 MRAY_1, 1 hit
PS01348 MRAY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q83GN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIAILLAVAF GITFTLFTTP FFIRLFRKIG WGQFIRLDGP RQHAIKRGTP
60 70 80 90 100
TMGGLVIVVA SIISYFLANF FLGLSVEPSG LLVIFMFVGM SLVGFLDDIL
110 120 130 140 150
KVRKQHSGGL GPFYKVVLQS FIAVPFALLT FLVKDARGIP HSSMSISFAR
160 170 180 190 200
DTGINFSALF SLGIIGVFSA WILYLLWINL IAVSSVNAVN ITDGLDGLAA
210 220 230 240 250
GAMIFTMLAY VVIGFWQSGQ NCARKSLPLE NISKCYSVNG PLDMSILAAA
260 270 280 290 300
ILGSLLGFLW WNTNPSKIMM GDTGALALGG AAAALSILTH TQLLFLVLGG
310 320 330 340 350
LFVIEAGSVI LQIAFYKKYR RRIFLMSPLH HHFELKGWAE ITVVVRFWII
360
AGLFTALGIG LFYADWLYS
Length:369
Mass (Da):40,339
Last modified:June 1, 2003 - v1
Checksum:i012D1FD9C0BA2721
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014184 Genomic DNA Translation: AAO44321.1
RefSeqiWP_011102440.1, NC_004572.3

Genome annotation databases

EnsemblBacteriaiAAO44321; AAO44321; TWT_224
GeneIDi29577912
KEGGitwh:TWT_224

Similar proteinsi

Entry informationi

Entry nameiMRAY_TROWT
AccessioniPrimary (citable) accession number: Q83GN4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health