Q83GM4 (Q83GM4_TROWT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dihydroorotate oxidase EMBL AAO44335.1
EC=1.3.3.1 EMBL AAO44335.1

Gene names

Name:	pyrD EMBL AAO44335.1
Ordered Locus Names:	TWT238
ORF Names:	TWT_238 EMBL AAO44335.1

Organism

Tropheryma whipplei (strain Twist) (Whipple's bacillus) [Complete proteome] [HAMAP]

Taxonomic identifier

203267 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor By similarity. SAAS SAAS012135
Catalytic activity	(S)-dihydroorotate + a quinone = orotate + a quinol. SAAS SAAS012135
Cofactor	Binds 1 FMN per subunit By similarity. SAAS SAAS012135
Pathway	Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1. SAAS SAAS012135
Subunit structure	Monomer By similarity. SAAS SAAS012135

Ontologies

Keywords
Biological process	Pyrimidine biosynthesis SAAS SAAS012135
Cellular component	Membrane SAAS SAAS012135
Ligand	FMN SAAS SAAS012135 Flavoprotein SAAS SAAS012135
Molecular function	Oxidoreductase SAAS SAAS012135 EMBL AAO44335.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro UMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	dihydroorotate oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	175	1	Nucleophile By similarity PIRSR PIRSR000164-1

Sequences

	Sequence		Length	Mass (Da)
	Q83GM4 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: B449B3D974C1C47F	FASTA	335	37,096
	10 20 30 40 50 60 MYSYFLNFLK CVDPELAHRI AAVALKSGLG MFVPQRFHIH LGTTSMGLYF DTPLGIAAGF 70 80 90 100 110 120 DKFADLVIPL YSLGFGHVEV GTVTLHPQPG NKKPRIHRVM SQKALINSMG FNNPGAQKMR 130 140 150 160 170 180 ENILKVRKSG RRLPIIGVNI GKSKVCPLEE SAKDYVKSFE LLADVSDYLV INVSSPNTEG 190 200 210 220 230 240 LRTLQSVGNL NKILRSVKPI ADRFKRPVLI KISPDLSNSD VTNIALLVKE FGLAGVVASN 250 260 270 280 290 300 TTTKRTGLPN EFSSLHGGLS GPMLKERSLE MLKILRRDLP KNKFCIISVG GVWDYTDVLE 310 320 330 RLEYGADLVQ GYTAFVYNGP YWASNINRDL SRLRS

References

[1]	"Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome." Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M. Genome Res. 13:1800-1809(2003) [PubMed: 12902375] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014184 Genomic DNA. Translation: AAO44335.1.
RefSeq	NP_787366.1. NC_004572.3.
3D structure databases
HSSP	HSSP built from PDB template 1D3G based on UniProtKB Q02127.
ProteinModelPortal	Q83GM4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q83GM4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1089301.
GenomeReviews	Gene locus TWT238 in contig AE014184_GR.
KEGG	twh:TWT238.
PATRIC	23996967. VBITroWhi72342_0367.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0167.
HOGENOM	HBG351027.
OMA	SYVTVNI.
PhylomeDB	Q83GM4.
ProtClustDB	PRK05286.
Enzyme and pathway databases
BioCyc	TWHI203267:TW238-MONOMER.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR012135. Dihydroorotate_DH_1_2. IPR005719. Dihydroorotate_DH_2. IPR001295. Dihydroorotate_DH_CS. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00226.
Pfam	PF01180. DHO_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000164. DHO_oxidase. 1 hit.
TIGRFAMs	TIGR01036. PyrD_sub2. 1 hit.
PROSITE	PS00911. DHODEHASE_1. 1 hit. PS00912. DHODEHASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q83GM4_TROWT

Accession

Primary (citable) accession number: Q83GM4

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	December 14, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)