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Q83GH8

- DEF_TROWT

UniProt

Q83GH8 - DEF_TROWT

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Protein
Peptide deformylase
Gene
def, TWT_310
Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi141 – 1411Iron By similarity
Metal bindingi183 – 1831Iron By similarity
Active sitei184 – 1841 By similarity
Metal bindingi187 – 1871Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciTWHI203267:GJDK-331-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:TWT_310
OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
Taxonomic identifieri203267 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000002200: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Peptide deformylaseUniRule annotation
PRO_0000082871Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203267.TWT310.

Structurei

3D structure databases

ProteinModelPortaliQ83GH8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
KOiK01462.
OMAiQQANNST.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83GH8-1 [UniParc]FASTAAdd to Basket

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MSQDRRYTGC NTHSNTHSAQ DREKEGAVPK ISGGKILPIY ITGHAVLHAP    50
AKPVTDFSGI QEIVRDMFAT MFAAPGVGLA GPQIGLGLRI FVYSYTEGDT 100
LHQGVAINPD LLIPKGVPKR QTNKQQANNS TSCDEPDREG CLSFPGYQFP 150
LERAPQVTLS AFDENKKPFT VHATGWLARI FQHEFDHLQG TLYVDRLAQK 200
YSGEVRQAVL NNKWGIPGKY WVPQEPKE 228
Length:228
Mass (Da):25,290
Last modified:June 1, 2003 - v1
Checksum:iA02523288B7E07C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014184 Genomic DNA. Translation: AAO44407.1.
RefSeqiNP_787438.1. NC_004572.3.

Genome annotation databases

EnsemblBacteriaiAAO44407; AAO44407; TWT_310.
GeneIDi1089563.
KEGGitwh:TWT310.
PATRICi23997121. VBITroWhi72342_0440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014184 Genomic DNA. Translation: AAO44407.1 .
RefSeqi NP_787438.1. NC_004572.3.

3D structure databases

ProteinModelPortali Q83GH8.
ModBasei Search...

Protein-protein interaction databases

STRINGi 203267.TWT310.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO44407 ; AAO44407 ; TWT_310 .
GeneIDi 1089563.
KEGGi twh:TWT310.
PATRICi 23997121. VBITroWhi72342_0440.

Phylogenomic databases

eggNOGi COG0242.
KOi K01462.
OMAi QQANNST.
OrthoDBi EOG664CMF.

Enzyme and pathway databases

BioCyci TWHI203267:GJDK-331-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
    Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
    Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Twist.

Entry informationi

Entry nameiDEF_TROWT
AccessioniPrimary (citable) accession number: Q83GH8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2003
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi