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Q83GH4 (UPPP_TROWT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:TWT_315
OrganismTropheryma whipplei (strain Twist) (Whipple's bacillus) [Complete proteome] [HAMAP]
Taxonomic identifier203267 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma

Protein attributes

Sequence length279 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 279279Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151233

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane39 – 5921Helical; Potential
Transmembrane96 – 11621Helical; Potential
Transmembrane128 – 14821Helical; Potential
Transmembrane155 – 17521Helical; Potential
Transmembrane201 – 22121Helical; Potential
Transmembrane231 – 25121Helical; Potential
Transmembrane259 – 27921Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q83GH4 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 80AFF569A9E0F289

FASTA27930,812
        10         20         30         40         50         60 
MVLEAVLLGI VQGITEFLPI SSTAHMYILA KLLNLHVPGR FFLSSVQLGT SFALILYFFK 

        70         80         90        100        110        120 
DVKGIISETS RSIYSFIQFG IRQKQGKRNE YTRLGLLLVT GTIPVVLLGF LLVRFVPDGF 

       130        140        150        160        170        180 
FSAARNLFTM GVALIVFGLL LGFADALFRR KKGNIFQITF IESVLIGAAQ VFAIIPGVSR 

       190        200        210        220        230        240 
SGITITTARF LNFDRQLAVR FSFLLSLPVT FIGGMYGLVA GPDTDYYSLG YSLIGAIVSF 

       250        260        270 
VVGLLVVSAL LRIISKTTFV LFVYYRVLFG LFLVIVSFF 

« Hide

References

[1]"Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Twist.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014184 Genomic DNA. Translation: AAO44412.1.
RefSeqNP_787443.1. NC_004572.3.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING203267.TWT315.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO44412; AAO44412; TWT_315.
GeneID1089569.
KEGGtwh:TWT315.
PATRIC23997133. VBITroWhi72342_0445.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBCLSK229775.

Enzyme and pathway databases

BioCycTWHI203267:GJDK-337-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_TROWT
AccessionPrimary (citable) accession number: Q83GH4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: February 19, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families