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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA, upk
Ordered Locus Names:TWT_315
OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
Taxonomic identifieri203267 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesTropheryma
Proteomesi
  • UP000002200 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei39 – 59HelicalUniRule annotationAdd BLAST21
Transmembranei96 – 116HelicalUniRule annotationAdd BLAST21
Transmembranei128 – 148HelicalUniRule annotationAdd BLAST21
Transmembranei155 – 175HelicalUniRule annotationAdd BLAST21
Transmembranei201 – 221HelicalUniRule annotationAdd BLAST21
Transmembranei231 – 251HelicalUniRule annotationAdd BLAST21
Transmembranei259 – 279HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001512331 – 279Undecaprenyl-diphosphataseAdd BLAST279

Interactioni

Protein-protein interaction databases

STRINGi203267.TWT315.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
KOiK06153.
OMAiKVFDIAI.
OrthoDBiPOG091H00ZR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83GH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLEAVLLGI VQGITEFLPI SSTAHMYILA KLLNLHVPGR FFLSSVQLGT
60 70 80 90 100
SFALILYFFK DVKGIISETS RSIYSFIQFG IRQKQGKRNE YTRLGLLLVT
110 120 130 140 150
GTIPVVLLGF LLVRFVPDGF FSAARNLFTM GVALIVFGLL LGFADALFRR
160 170 180 190 200
KKGNIFQITF IESVLIGAAQ VFAIIPGVSR SGITITTARF LNFDRQLAVR
210 220 230 240 250
FSFLLSLPVT FIGGMYGLVA GPDTDYYSLG YSLIGAIVSF VVGLLVVSAL
260 270
LRIISKTTFV LFVYYRVLFG LFLVIVSFF
Length:279
Mass (Da):30,812
Last modified:June 1, 2003 - v1
Checksum:i80AFF569A9E0F289
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014184 Genomic DNA. Translation: AAO44412.1.
RefSeqiWP_011102498.1. NC_004572.3.

Genome annotation databases

EnsemblBacteriaiAAO44412; AAO44412; TWT_315.
KEGGitwh:TWT_315.
PATRICi23997133. VBITroWhi72342_0445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014184 Genomic DNA. Translation: AAO44412.1.
RefSeqiWP_011102498.1. NC_004572.3.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi203267.TWT315.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO44412; AAO44412; TWT_315.
KEGGitwh:TWT_315.
PATRICi23997133. VBITroWhi72342_0445.

Phylogenomic databases

eggNOGiENOG4105DWR. Bacteria.
COG1968. LUCA.
KOiK06153.
OMAiKVFDIAI.
OrthoDBiPOG091H00ZR.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase. 1 hit.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUPPP_TROWT
AccessioniPrimary (citable) accession number: Q83GH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: November 2, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.