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Q83GH3 (SYC2_TROWT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Putative cysteine--tRNA ligase 2
EC=6.1.1.16
Alternative name(s):
Cysteinyl-tRNA synthetase 2
Short name=CysRS 2
Gene names
Name:cysS2
Ordered Locus Names:TWT_316
OrganismTropheryma whipplei (strain Twist) (Whipple's bacillus) [Complete proteome] [HAMAP]
Taxonomic identifier203267 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys). HAMAP MF_00041

Subunit structure

Monomer By similarity. HAMAP MF_00041

Subcellular location

Cytoplasm HAMAP MF_00041.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcysteinyl-tRNA aminoacylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

cysteine-tRNA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450Putative cysteine--tRNA ligase 2 HAMAP MF_00041
PRO_0000159515

Regions

Motif29 – 3911"HIGH" region HAMAP MF_00041
Motif270 – 2745"KMSKS" region HAMAP MF_00041

Sites

Binding site2731ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83GH3 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: 2754844783A8B17D

FASTA45051,274
        10         20         30         40         50         60 
MYTFEVFDSR TRSIVKLEDC LLRLYVCGIT PYKSTHLGHA FTYVGFDTLF RLALDSGRDV 

        70         80         90        100        110        120 
LYIQNISDID EPLFQYAEKV GIHYKDLART QTKRFFEDMH TLECLPPGYV IPVSKVLDGI 

       130        140        150        160        170        180 
KTGIEGLISR NMAYKLPNGD VYFDSTLTDP GKMFCFDRKT AMSLMLETDT GKNPFDPLLW 

       190        200        210        220        230        240 
RGRGAEPQWE ASFGAGRPAW HISCAVLSNL QTQYENVLHI YGGGRDLAFP HHEFTNVLSK 

       250        260        270        280        290        300 
LIRAPKDNKQ QDTVQDVFMH TGLVSYMGDK MSKSKGNLVF ISQLREQCEK IGLHHSVIRL 

       310        320        330        340        350        360 
ALLQRHYRED WEWQDECLDR AASRFRLWKS ALQEYIGAKG IRSTADQNKG TQGAWERIHG 

       370        380        390        400        410        420 
GVFDSNFDHR QPIHPKHSPQ MRDYSEHGSA GQNGTDLDLS LYQAIRFHLC NDLDTPKALD 

       430        440        450 
AVDSYARKGT ITIPEARAVE KLLGIPLTRV

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References

[1]"Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
Genome Res. 13:1800-1809(2003) [PubMed: 12902375] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Twist.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014184 Genomic DNA. Translation: AAO44413.1.
RefSeqNP_787444.1. NC_004572.3.

3D structure databases

ProteinModelPortalQ83GH3.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ83GH3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1089570.
GenomeReviewsGene locus TWT_316 in contig AE014184_GR.
KEGGtwh:TWT316.
PATRIC23997135. VBITroWhi72342_0446.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0215.
HOGENOMHBG327651.
OMAALFREDM.
ProtClustDBCLSK229740.

Enzyme and pathway databases

BioCycTWHI203267:TW316-MONOMER.

Family and domain databases

HAMAPMF_00041. Cys_tRNA_synth. Divergent sequence.
[Tree]
InterProIPR024909. Cys-tRNA/MSH_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 2 hits.
KOK01883.
PANTHERPTHR10890. Cys_tRNA-synt_1a. 1 hit.
PfamPF01406. tRNA-synt_1e. 1 hit.
[Graphical view]
PRINTSPR00983. TRNASYNTHCYS.
PROSITEPS00178. AA_TRNA_LIGASE_I. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYC2_TROWT
AccessionPrimary (citable) accession number: Q83GH3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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