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Q83GE9 (SYR_TROWT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:TWT_351
OrganismTropheryma whipplei (strain Twist) (Whipple's bacillus) [Complete proteome] [HAMAP]
Taxonomic identifier203267 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma

Protein attributes

Sequence length552 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 552552Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242118

Regions

Motif124 – 13411"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q83GE9 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: A74E3374662C9704

FASTA55262,999
        10         20         30         40         50         60 
MNVEDLKKSV TNIVHSMYNF DCSEIVSLTR PPKPEYGDWA LSLPLKLASL LKSPAIDIAQ 

        70         80         90        100        110        120 
SIASALLELD GVQDVYVAKP GFINLKLSRE HTTGIISEVL EQGSSFGRNT TQSSKKINLE 

       130        140        150        160        170        180 
FVSGNPTGPL HLAHTRWAAV GDSIARILIN CGADVTREYY INNVGNQIHL FSESVYARAL 

       190        200        210        220        230        240 
SKSLPKDGYP GEYVKDIARR IQCEFPNIID LSYEDAIKIF RKRSWQIQIE EIKKSCIAFR 

       250        260        270        280        290        300 
VNFDVWFSEE SLHEPDRFGK SQIDKALARC KQNGYLFQKN GAFFIRTTEF GDDKDRAVLR 

       310        320        330        340        350        360 
SDTSYTYYAA DCAYYLNKIN RGFSDLVILV GADHHGYVKR FQAMSNIFHV DSENNRKNVQ 

       370        380        390        400        410        420 
VLLGQMVLLK NKRQSKREGN VIGLSEIIQS VGVDPLRFWF CRYPIDTPID LDEQHLKKRS 

       430        440        450        460        470        480 
NDNPVYYVQY AYARTRSLIR SANLLQMEKF GFFPELLVHE TETALVSLLY DYKTVVIDAA 

       490        500        510        520        530        540 
RFLQPHRVVR YLESLAGAYH KWYDKCRIIP RKGILDKSEA ELVNTRLELN RAVGQVLYNA 

       550 
LDLIGVSAPE RM 

« Hide

References

[1]"Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Twist.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014184 Genomic DNA. Translation: AAO44448.1.
RefSeqNP_787479.1. NC_004572.3.

3D structure databases

ProteinModelPortalQ83GE9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING203267.TWT351.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAO44448; AAO44448; TWT_351.
GeneID1089488.
KEGGtwh:TWT351.
PATRIC23997215. VBITroWhi72342_0485.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
OMAQQEVFRS.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycTWHI203267:GJDK-375-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSYR_TROWT
AccessionPrimary (citable) accession number: Q83GE9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries