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Q83GC6

- SYL_TROWT

UniProt

Q83GC6 - SYL_TROWT

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei574 – 5741ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTWHI203267:GJDK-410-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:TWT_385
OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
Taxonomic identifieri203267 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000002200: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 806806Leucine--tRNA ligasePRO_0000152111Add
BLAST

Proteomic databases

PRIDEiQ83GC6.

Interactioni

Protein-protein interaction databases

STRINGi203267.TWT385.

Structurei

3D structure databases

ProteinModelPortaliQ83GC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi54 – 6411"HIGH" regionAdd
BLAST
Motifi571 – 5755"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiEICAPEQ.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83GC6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHALRALDTL CENMEYNFRA LEEKWAPIWE RDRLFEVDEN DSETPRKYVL
60 70 80 90 100
DMFSYPSGDL HMGHAETYAY GDFIARYWRH RGYNVLHPVG WDSFGLPAEN
110 120 130 140 150
AAIKHGSDPK VWTYRNIDQQ ARSMRLYAAS FDWSRRLHTS DPEYYRWNQW
160 170 180 190 200
LFLKLYKHGL AYRKKAWVNW DPSDRTVLAN EQVLPDGTSE RSGALVVKKK
210 220 230 240 250
LTQWFLRITA YADRLLDDLS MLENNWPERV ITMQRNWIGR SEGVSIEFNI
260 270 280 290 300
PTLKRPVTVF TTRPETIFGV TYLALAFDSE VTEELASKSG VLGELLELRH
310 320 330 340 350
NIDKTHEGVR GLDLKSFAIH PLTGQSVPIF AASYILSDYA KGAVMSVPGH
360 370 380 390 400
DTRDERFAVR YNLPIVKIME DNRLISSGKY SGQSVTQARE NITRDLCAKS
410 420 430 440 450
LGRREISYRL RDWLISRQRY WGTPIPILYD SNGSEIPVEE DDLPVLLPDS
460 470 480 490 500
EGIDLTPSGL SPLGGIHDWV NLHKAGSLFR RDTDTMDTFF DSSWYFLRYL
510 520 530 540 550
NPDCDTAPFT LEKAKKWGPV DQYCGGVEHA VLHLLYARFI TKFLYDIGFV
560 570 580 590 600
DFKEPFLRLI NQGMVVLNGA KMSKSKGNIV EFSKEVSQHG VDVIRFALIF
610 620 630 640 650
SGPPEEDIDW KDVSMTGAAR FLSRCIQTAK EVPKRTADLS LGDIELRKHT
660 670 680 690 700
HSLLNDIDWL VDSYRFNVIA ARLMDLLNIT RKKIQTIGAD NPAIREAIET
710 720 730 740 750
IAIALDMFSP YTAEEMWEIL GNKYSVSKAL FPEVDTTFLE QKTTCAIVQI
760 770 780 790 800
DGRLRGRLNV LTNITTEQLV HSARSLPAIE HALSGRSVKR VICVPPKLVN

FVVEPK
Length:806
Mass (Da):92,300
Last modified:June 1, 2003 - v1
Checksum:i6A6153B7178A397B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014184 Genomic DNA. Translation: AAO44482.1.
RefSeqiNP_787513.1. NC_004572.3.

Genome annotation databases

EnsemblBacteriaiAAO44482; AAO44482; TWT_385.
GeneIDi1089449.
KEGGitwh:TWT385.
PATRICi23997291. VBITroWhi72342_0522.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014184 Genomic DNA. Translation: AAO44482.1 .
RefSeqi NP_787513.1. NC_004572.3.

3D structure databases

ProteinModelPortali Q83GC6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203267.TWT385.

Proteomic databases

PRIDEi Q83GC6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO44482 ; AAO44482 ; TWT_385 .
GeneIDi 1089449.
KEGGi twh:TWT385.
PATRICi 23997291. VBITroWhi72342_0522.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi EICAPEQ.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci TWHI203267:GJDK-410-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
    Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
    Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Twist.

Entry informationi

Entry nameiSYL_TROWT
AccessioniPrimary (citable) accession number: Q83GC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3