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Q83GA1

- GATA_TROWT

UniProt

Q83GA1 - GATA_TROWT

Protein

Glutamyl-tRNA(Gln) amidotransferase subunit A

Gene

gatA

Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).UniRule annotation

    Catalytic activityi

    ATP + L-glutamyl-tRNA(Gln) + L-glutamine = ADP + phosphate + L-glutaminyl-tRNA(Gln) + L-glutamate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei109 – 1091Charge relay systemUniRule annotation
    Active sitei184 – 1841Charge relay systemUniRule annotation
    Active sitei208 – 2081Acyl-ester intermediateUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTWHI203267:GJDK-443-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamyl-tRNA(Gln) amidotransferase subunit AUniRule annotation (EC:6.3.5.7UniRule annotation)
    Short name:
    Glu-ADT subunit AUniRule annotation
    Gene namesi
    Name:gatAUniRule annotation
    Ordered Locus Names:TWT_412
    OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
    Taxonomic identifieri203267 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
    ProteomesiUP000002200: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 524524Glutamyl-tRNA(Gln) amidotransferase subunit APRO_0000105226Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotrimer of A, B and C subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi203267.TWT412.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83GA1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the amidase family. GatA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0154.
    KOiK02433.
    OMAiMAMYLND.
    OrthoDBiEOG61P6R9.

    Family and domain databases

    Gene3Di3.90.1300.10. 1 hit.
    HAMAPiMF_00120. GatA.
    InterProiIPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    IPR004412. GatA.
    [Graphical view]
    PANTHERiPTHR11895. PTHR11895. 1 hit.
    PfamiPF01425. Amidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF75304. SSF75304. 1 hit.
    TIGRFAMsiTIGR00132. gatA. 1 hit.
    PROSITEiPS00571. AMIDASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q83GA1-1 [UniParc]FASTAAdd to Basket

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    MIRRAPFLIL LRFCRMGKMA CSGYPPFQGR IVLSEMPAHR LAALIRSKEV    50
    SALEVAESFI DNIEASDSRI CAFLYTDFSY TRDVARRVDE ELKSATKLSP 100
    LAGVPIAVKD MILTRDMPTT AGSKILEGWI PPYNATVIER ISRARMPILG 150
    KTNQDEFGMG SSTEYSAYKT TRNPWDLSRT AGGSGGGSSA AVSASQAPLA 200
    LGTDTGGSIR LPAHCTGTVG IRPTYGSVSR YGVIALASSF DQVGPCSSNI 250
    LDAALLHEVI AGYDPADAVS IKDQDLNFSQ AAYEGANRGI SGVRLGFVNP 300
    SNWCNSKITD LFGRTLKSLE SEGAVLHEVQ FPNFDHAVQA YYLIMQAEAS 350
    SNLSRYDSIR FGPQEMAASA SGTVSKTRSI RFGPEVKRRI LLGTHILSAG 400
    YYDDFYMSAQ KIRLLVKRDF AKIFSLVDVL LLPTAPTPAF KLGEKIDHHT 450
    SMYKSDTATT PASLAGLPAG SIPMGVIDGL PVGLQIIAPG QFDSRVYSTG 500
    AAIEQIIGDI HAMKNTKHNT GQTA 524
    Length:524
    Mass (Da):56,455
    Last modified:June 1, 2003 - v1
    Checksum:i925927E8D616705A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014184 Genomic DNA. Translation: AAO44509.1.
    RefSeqiNP_787540.1. NC_004572.3.
    WP_011102561.1. NC_004572.3.

    Genome annotation databases

    EnsemblBacteriaiAAO44509; AAO44509; TWT_412.
    GeneIDi1089420.
    KEGGitwh:TWT412.
    PATRICi23997359. VBITroWhi72342_0550.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014184 Genomic DNA. Translation: AAO44509.1 .
    RefSeqi NP_787540.1. NC_004572.3.
    WP_011102561.1. NC_004572.3.

    3D structure databases

    ProteinModelPortali Q83GA1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203267.TWT412.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO44509 ; AAO44509 ; TWT_412 .
    GeneIDi 1089420.
    KEGGi twh:TWT412.
    PATRICi 23997359. VBITroWhi72342_0550.

    Phylogenomic databases

    eggNOGi COG0154.
    KOi K02433.
    OMAi MAMYLND.
    OrthoDBi EOG61P6R9.

    Enzyme and pathway databases

    BioCyci TWHI203267:GJDK-443-MONOMER.

    Family and domain databases

    Gene3Di 3.90.1300.10. 1 hit.
    HAMAPi MF_00120. GatA.
    InterProi IPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    IPR004412. GatA.
    [Graphical view ]
    PANTHERi PTHR11895. PTHR11895. 1 hit.
    Pfami PF01425. Amidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF75304. SSF75304. 1 hit.
    TIGRFAMsi TIGR00132. gatA. 1 hit.
    PROSITEi PS00571. AMIDASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
      Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
      Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Twist.

    Entry informationi

    Entry nameiGATA_TROWT
    AccessioniPrimary (citable) accession number: Q83GA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2003
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3