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Q83G94

- PNP_TROWT

UniProt

Q83G94 - PNP_TROWT

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, TWT_421
Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi528 – 5281Magnesium By similarity
Metal bindingi534 – 5341Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciTWHI203267:GJDK-452-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:TWT_421
OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
Taxonomic identifieri203267 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000002200: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329924Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203267.TWT421.

Structurei

3D structure databases

ProteinModelPortaliQ83G94.
SMRiQ83G94. Positions 2-630.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini594 – 65360KH
Add
BLAST
Domaini665 – 73773S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83G94-1 [UniParc]FASTAAdd to Basket

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MDDVQFSEGV IDNGRFGTRT IRFETGRLAR QAQGSVVAYL DGETMLLSST    50
SVGKQPKEDC DFFPLTVDVE ERSYAAGKIP GSYFRREGRP STEAILACRL 100
IDRPLRPSFN AGLRNEVQVI VTVLSIAPGE FYEALAINAA SASTLVSGLP 150
FSGPIGGVRL ALIDGQWVAF PRYEDLSGAV FDLTVAGRVF VNESGKEDIA 200
IMMVEAEATE SAWDLIHSHG AKKPNEEVIE EGIESAKVFI RTLCDIQRDL 250
ASKLSLSHTE PDLYPDYSDS VHSFVEGLVK SDLEKVYRGN HDSGYAPNAL 300
SASDEIKQKA YDAFHDAVLS GRFDQDSLSQ FPHAYKAVLK DVVRTCVLEG 350
FARMDGRGLS DIRPLDAEVQ VVPRVHGSAV FQRGETQVLG VTTLNMLKME 400
QQIDSLAPIV SKRYIHHYNF PPYSTGEVGR VGSPKRREIG HGFLAERALV 450
PVLPSREDFP YAIRQVSEAL GSNGSTSMGS VCASTLSLLN AGVPLRAPVA 500
GIAMGLISGR VDGEMRYVTL TDISGSEDAL GDMDFKVAGT SDFITALQLD 550
TKLDGIPAHV LSEALAHARS ARLAILDVLT RVIDSPDQMS EYAPRVVRVK 600
IPVQKIGELI GPKGKVINSI QDETGAEISI EDDGTVYIGS SQADSSEKAV 650
AMVNSIVNPV EPCVGSQFLG TVVKNMPFGS FISLVPGKDG LLHISEIRKM 700
VDGRHLESVD EVLSVGQKVL VEVSKIDDRG KLCLVAVK 738
Length:738
Mass (Da):79,815
Last modified:June 1, 2003 - v1
Checksum:i51BD61D3D4B8A996
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014184 Genomic DNA. Translation: AAO44518.1.
RefSeqiNP_787549.1. NC_004572.3.

Genome annotation databases

EnsemblBacteriaiAAO44518; AAO44518; TWT_421.
GeneIDi1089410.
KEGGitwh:TWT421.
PATRICi23997377. VBITroWhi72342_0559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014184 Genomic DNA. Translation: AAO44518.1 .
RefSeqi NP_787549.1. NC_004572.3.

3D structure databases

ProteinModelPortali Q83G94.
SMRi Q83G94. Positions 2-630.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203267.TWT421.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO44518 ; AAO44518 ; TWT_421 .
GeneIDi 1089410.
KEGGi twh:TWT421.
PATRICi 23997377. VBITroWhi72342_0559.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci TWHI203267:GJDK-452-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
    Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
    Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Twist.

Entry informationi

Entry nameiPNP_TROWT
AccessioniPrimary (citable) accession number: Q83G94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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