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Q83G94

- PNP_TROWT

UniProt

Q83G94 - PNP_TROWT

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Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi528 – 5281MagnesiumUniRule annotation
Metal bindingi534 – 5341MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciTWHI203267:GJDK-452-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:TWT_421
OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
Taxonomic identifieri203267 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000002200: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 738738Polyribonucleotide nucleotidyltransferasePRO_0000329924Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi203267.TWT421.

Structurei

3D structure databases

ProteinModelPortaliQ83G94.
SMRiQ83G94. Positions 2-630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini594 – 65360KHUniRule annotationAdd
BLAST
Domaini665 – 73773S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q83G94-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDDVQFSEGV IDNGRFGTRT IRFETGRLAR QAQGSVVAYL DGETMLLSST
60 70 80 90 100
SVGKQPKEDC DFFPLTVDVE ERSYAAGKIP GSYFRREGRP STEAILACRL
110 120 130 140 150
IDRPLRPSFN AGLRNEVQVI VTVLSIAPGE FYEALAINAA SASTLVSGLP
160 170 180 190 200
FSGPIGGVRL ALIDGQWVAF PRYEDLSGAV FDLTVAGRVF VNESGKEDIA
210 220 230 240 250
IMMVEAEATE SAWDLIHSHG AKKPNEEVIE EGIESAKVFI RTLCDIQRDL
260 270 280 290 300
ASKLSLSHTE PDLYPDYSDS VHSFVEGLVK SDLEKVYRGN HDSGYAPNAL
310 320 330 340 350
SASDEIKQKA YDAFHDAVLS GRFDQDSLSQ FPHAYKAVLK DVVRTCVLEG
360 370 380 390 400
FARMDGRGLS DIRPLDAEVQ VVPRVHGSAV FQRGETQVLG VTTLNMLKME
410 420 430 440 450
QQIDSLAPIV SKRYIHHYNF PPYSTGEVGR VGSPKRREIG HGFLAERALV
460 470 480 490 500
PVLPSREDFP YAIRQVSEAL GSNGSTSMGS VCASTLSLLN AGVPLRAPVA
510 520 530 540 550
GIAMGLISGR VDGEMRYVTL TDISGSEDAL GDMDFKVAGT SDFITALQLD
560 570 580 590 600
TKLDGIPAHV LSEALAHARS ARLAILDVLT RVIDSPDQMS EYAPRVVRVK
610 620 630 640 650
IPVQKIGELI GPKGKVINSI QDETGAEISI EDDGTVYIGS SQADSSEKAV
660 670 680 690 700
AMVNSIVNPV EPCVGSQFLG TVVKNMPFGS FISLVPGKDG LLHISEIRKM
710 720 730
VDGRHLESVD EVLSVGQKVL VEVSKIDDRG KLCLVAVK
Length:738
Mass (Da):79,815
Last modified:June 1, 2003 - v1
Checksum:i51BD61D3D4B8A996
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014184 Genomic DNA. Translation: AAO44518.1.
RefSeqiNP_787549.1. NC_004572.3.
WP_011102569.1. NC_004572.3.

Genome annotation databases

EnsemblBacteriaiAAO44518; AAO44518; TWT_421.
GeneIDi1089410.
KEGGitwh:TWT421.
PATRICi23997377. VBITroWhi72342_0559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014184 Genomic DNA. Translation: AAO44518.1 .
RefSeqi NP_787549.1. NC_004572.3.
WP_011102569.1. NC_004572.3.

3D structure databases

ProteinModelPortali Q83G94.
SMRi Q83G94. Positions 2-630.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203267.TWT421.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO44518 ; AAO44518 ; TWT_421 .
GeneIDi 1089410.
KEGGi twh:TWT421.
PATRICi 23997377. VBITroWhi72342_0559.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci TWHI203267:GJDK-452-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
    Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
    Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Twist.

Entry informationi

Entry nameiPNP_TROWT
AccessioniPrimary (citable) accession number: Q83G94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2003
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3