Reviewed, UniProtKB/Swiss-Prot Q83G49 (CLPP1_TROWT)

Names and origin

Protein names

Recommended name:
    ATP-dependent Clp protease proteolytic subunit 1
    EC=3.4.21.92
Alternative name(s):
    Endopeptidase Clp 1

Gene names

Name:	clpP1
Ordered Locus Names:	TWT_480

Organism

Tropheryma whipplei (strain Twist) (Whipple's bacillus) [Complete proteome] [HAMAP]

Taxonomic identifier

203267 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity.
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S14 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	ATP-dependent Clp protease proteolytic subunit 1 HAMAP MF_00444		PRO_0000179708
Sites
	Active site	103	1	By similarity
	Active site	128	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q83G49-1 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 5754570E8F31C42C	FASTA	207	22,956
	10 20 30 40 50 60 MYPNSRYILP SLDERTAYGY KQVDPYTKLF EDRIVFLGVQ IDDASADDVM AQLLVLEGQD 70 80 90 100 110 120 AERDIIMYIN SPGGSFTAMT AIYDTMQYIR PQIQTVCLGQ AASAAAVILS AGTPGKRLAL 130 140 150 160 170 180 PNARILIHQP VVASSGYGQA SDIEIQAREI MRMREWLEKT LAQHSNKSVK QVSKDIDRDK 190 200 ILSSEQALEY GLIDQILVSR KAGLGKK

References

[1]	"Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome." Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M. Genome Res. 13:1800-1809(2003) [PubMed: 12902375] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014184 Genomic DNA. Translation: AAO44577.1.
RefSeq	NP_787608.1.
3D structure databases
HSSP	HSSP built from PDB template 1TYF based on UniProtKB P19245.
ModBase	Search...
Protein-protein interaction databases
STRING	Q83G49.
Genome annotation databases
GeneID	1089360.
GenomeReviews	Gene locus TWT_480 in contig AE014184_GR.
KEGG	twh:TWT480.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q83G49.
OMA	ANEILRM.
Enzyme and pathway databases
BioCyc	TWHI203267:TW480-MON.
Family and domain databases
HAMAP	MF_00444. [Tree]
InterPro	IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CLPP1_TROWT

Accession

Primary (citable) accession number: Q83G49

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	June 1, 2003
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)