Q83G24 (Q83G24_TROWT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
DNA polymerase III alpha chain EMBL AAO44607.1
EC=2.7.7.7 EMBL AAO44607.1

Gene names

Name:	dnaE EMBL AAO44607.1
Ordered Locus Names:	TWT510
ORF Names:	TWT_510 EMBL AAO44607.1

Organism

Tropheryma whipplei (strain Twist) (Whipple's bacillus) [Complete proteome] [HAMAP]

Taxonomic identifier

203267 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length	1164 AA.
Sequence status	Complete.
Protein existence	Predicted

General annotation (Comments)

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). SAAS SAAS004013

Ontologies

Keywords
Biological process	DNA replication SAAS SAAS004013
Cellular component	Cytoplasm SAAS SAAS004013
Molecular function	DNA-directed DNA polymerase SAAS SAAS004013 Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q83G24 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 71F5444E872B82E1	FASTA	1,164	130,860
	10 20 30 40 50 60 MRDYMSFVHL HVHTDYSMLD GAARTEDLMR KAAEDKMPAI AITDHGNTFG AFDFWKTAKT 70 80 90 100 110 120 YDINPIIGME AYLTPGTNRK EKVRKFFASG GPDDVSAGGA YTHLTLLSQN NEGMHNLFKL 130 140 150 160 170 180 SSLASIEGYY FKPRIDIELL NQYSNGLIAT TGCPSGEIQT RLRLGQYSEA RQAAAQMRDI 190 200 210 220 230 240 FGPENYYCEV MDHNLEIEKA VMPDLLRLAG DLGLPLLATN DLHYVNSEDS ASHAALLCVQ 250 260 270 280 290 300 SGSTINDPNR FKFDSDEFYL KSSSEMRILF EDLPEACDNT LLVAERCHIN FDTQRSFMPR 310 320 330 340 350 360 FSVPEGETEN SWFASEVKRG IASRYPNGPS RRVIEQAEYE IRVVQEAGYA GYFLIVADFI 370 380 390 400 410 420 NWAKLNGIRV GPGRGSGAAS MAAYAMRITD LDPLEHGLIF ERFLNPARIS MPDFDIDFDE 430 440 450 460 470 480 RRRGEVIDYV TKKYGSDHVA QIVTFATIKA KQALKDSARV LSYPYSFGER LTKAMPPAVM 490 500 510 520 530 540 GREIPLRAIF DTTHSRHREA SEVRQMIESD YEMQQIFNTA KGLENLKRQW AVHAAGVIMS 550 560 570 580 590 600 DAPIIDIIPI MKRESDGHIV TQFDYASCES LGLVKMDFLG LRNLTIIDDA LANIRQNKNT 610 620 630 640 650 660 KVDLENLPLD DPEVYKLLRR ADTLGVFQLD SGPIRQLLEL MQPDSFDDIS AAIALYRPGP 670 680 690 700 710 720 MGARSHTNYA LRKNRKQEID HIHPELTKDL SVLLSSTYGL IVYQEQVIGI AQKLAGFTLE 730 740 750 760 770 780 EADVLRWAMG KKKKDELDRQ YNKFANGMRK AGYSDGATEA LWNVLLPFSD YAFNKAHATA 790 800 810 820 830 840 YGLISYWTAY LKAHYPTEYM AALLTSVETS RDKLGLYLQE CRHMCIKVLL PDINVSRSGF 850 860 870 880 890 900 TPSGENILFG LGAIKNVGAN LIDDILEVRE DGPFVSLIDF VQRMPHSVLN RRSVMSLIQA 910 920 930 940 950 960 GAFDSIHPNR RSLMDIHRSV LENCQANARR SDVSLLDGLL DEYEGFSPPD IPDWDNRERL 970 980 990 1000 1010 1020 KYEREMLGMY VSSHPLDGLE DSLLKFRDCS IAECISRKPQ DVIRVAGLIT SVEHKVARRT 1030 1040 1050 1060 1070 1080 GMRYAHAILE DTSGEIQIML SGQNYNNFSE QLVTDSIVSV TGRISFRDDA TTLYCDSIKD 1090 1100 1110 1120 1130 1140 VLPVKKEARL RLKCSEGFLT QNVFIALDDV LRKYPGDTPV TMEVIITDNS VVKSKTFELS 1150 1160 RCVEISNDLI AEVKGILGIE GISG

References

[1]	"Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome." Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M. Genome Res. 13:1800-1809(2003) [PubMed: 12902375] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014184 Genomic DNA. Translation: AAO44607.1.
RefSeq	NP_787638.1. NC_004572.3.
3D structure databases
ProteinModelPortal	Q83G24.
ModBase	Search...
Protein-protein interaction databases
STRING	Q83G24.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1482495.
GenomeReviews	Gene locus TWT510 in contig AE014184_GR.
KEGG	twh:TWT510.
PATRIC	23997583. VBITroWhi72342_0657.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0587.
HOGENOM	HBG734490.
OMA	RVLQMPY.
PhylomeDB	Q83G24.
ProtClustDB	PRK05673.
Enzyme and pathway databases
BioCyc	TWHI203267:TW510-MONOMER.
Family and domain databases
InterPro	IPR011708. DNA_pol3_alpha. IPR004365. NA-bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. Pol/His_phosphatase_N. IPR016195. Pol/histidinol_Pase-like. IPR004805. PolC_alpha. [Graphical view]
KO	K02337.
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
SUPFAM	SSF89550. PHP-like. 1 hit.
TIGRFAMs	TIGR00594. Polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q83G24_TROWT

Accession

Primary (citable) accession number: Q83G24

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2003
Last sequence update:	June 1, 2003
Last modified:	December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)