Q83FZ8 (RL5_TROWT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
50S ribosomal protein L5

Gene names

Name:	rplE
Ordered Locus Names:	TWT_542

Organism

Tropheryma whipplei (strain Twist) (Whipple's bacillus) [Complete proteome] [HAMAP]

Taxonomic identifier

203267 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length	183 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs By similarity. HAMAP MF_01333_B
Subunit structure	Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome By similarity.
Sequence similarities	Belongs to the ribosomal protein L5P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding tRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: InterPro
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro tRNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 183	183	50S ribosomal protein L5 HAMAP MF_01333_B		PRO_0000125020

Sequences

	Sequence		Length	Mass (Da)
	Q83FZ8 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 7351697A496629A3	FASTA	183	20,612
	10 20 30 40 50 60 MTCYTPRLLT RYREEIVPVL MSRFDINNVH QVPSITKIVV NSGVGDAARD SKIIEGAVSD 70 80 90 100 110 120 ITLITGQKPR INRAKQSIAK FKLREGQAVG VTATLRGRRM WEFLDRLLTL ALPRIRDFRG 130 140 150 160 170 180 ISDKQFDGHG NYTFGLSEQG IFHEIDQDKI DRVRGMDITV VTTSSSDDMA RALLGELGFP FKK

References

[1]

"Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome." Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M. Genome Res. 13:1800-1809(2003) [PubMed: 12902375] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Twist.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014184 Genomic DNA. Translation: AAO44639.1.
RefSeq	NP_787670.1. NC_004572.3.
3D structure databases
ProteinModelPortal	Q83FZ8.
SMR	Q83FZ8. Positions 6-183.
ModBase	Search...
Protein-protein interaction databases
STRING	Q83FZ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1482527.
GenomeReviews	Gene locus TWT_542 in contig AE014184_GR.
KEGG	twh:TWT542.
PATRIC	23997651. VBITroWhi72342_0691.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0094.
HOGENOM	HBG592167.
OMA	RQGMPIG.
PhylomeDB	Q83FZ8.
ProtClustDB	PRK00010.
Enzyme and pathway databases
BioCyc	TWHI203267:TW542-MONOMER.
Family and domain databases
HAMAP	MF_01333_B. Ribosomal_L5_B. [Tree]
InterPro	IPR002132. Ribosomal_L5. IPR020930. Ribosomal_L5_bac-type. IPR022803. Ribosomal_L5_domain. [Graphical view]
Gene3D	G3DSA:3.30.1440.10. Ribosomal_L5. 1 hit.
KO	K02931.
PANTHER	PTHR11994. Ribosomal_L5. 1 hit.
Pfam	PF00281. Ribosomal_L5. 1 hit. PF00673. Ribosomal_L5_C. 1 hit. [Graphical view]
PIRSF	PIRSF002161. Ribosomal_L5. 1 hit.
SUPFAM	SSF55282. Ribosomal_L5. 1 hit.
PROSITE	PS00358. RIBOSOMAL_L5. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RL5_TROWT

Accession

Primary (citable) accession number: Q83FZ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program