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Q83FU2

- GLMS_TROWT

UniProt

Q83FU2 - GLMS_TROWT

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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
Active sitei611 – 6111For Fru-6P isomerization activityUniRule annotation

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciTWHI203267:GJDK-645-MONOMER.

Protein family/group databases

MEROPSiC44.971.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:TWT_606
OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
Taxonomic identifieri203267 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
ProteomesiUP000002200: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedUniRule annotation
Chaini2 – 616615Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135407Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi203267.TWT606.

Structurei

3D structure databases

ProteinModelPortaliQ83FU2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 222221Glutamine amidotransferase type-2UniRule annotationAdd
BLAST
Domaini289 – 428140SIS 1UniRule annotationAdd
BLAST
Domaini461 – 606146SIS 2UniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
Contains 2 SIS domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiCOG0449.
KOiK00820.
OMAiCRIPCEV.
OrthoDBiEOG6KT2Q1.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS.
InterProiIPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q83FU2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGIIGYSGP RPAAEVLLKG LERLEYRGYD SAGIAVVTDK AYIESVKKSG
60 70 80 90 100
KLNVLKTCLE RRTTPIVGST GIGHTRWATH GEPSDRNAHP HMDTEQSLAI
110 120 130 140 150
VHNGIIENSD VLKRELLASG KSFTSETDTE VVAHLLSDAF KKTQDLVQAF
160 170 180 190 200
VEVTQRLEGA FAVVAIHKDQ PNTIVAAKNN SPLLLGFGQG ENFLASDIAA
210 220 230 240 250
FAEYTQRVAN IDQERIVALS GDSVYITDFA GHPVDYEVHT VSWHPASVDS
260 270 280 290 300
SGWSSFMLKE IFEEPQAVEN TLKGRTEDGT VILPECDHIR DDLLAIDRVV
310 320 330 340 350
LVGCGTAAYA AMTASYSIEA WAGLPVSVEL SHEFRYREPV LNSKTLAVFI
360 370 380 390 400
SQSGETMDSL MAVRYARQAG VKTISVCNVM DSSIPKESHA VIYTKAGPEV
410 420 430 440 450
AVASTKSFVC QIVVLYLLAL YLGQLRGFRS IFPRQKAVCE LNRLPVKLKQ
460 470 480 490 500
VLEIYESVRQ LAHWMSDSRS ILFLGRHAGY PIALEAALKL KELAYIHAEG
510 520 530 540 550
FAAGELKHGP IALIEPGQPV FVIVPSPVGS PILHAKVISN IREIKSRGAR
560 570 580 590 600
IIAIAAEGDS AVLPHTDSVL RIPLTRYSFE PLLSIVPLQI FALELAADKG
610
FDVDRPRNLA KSVTVE
Length:616
Mass (Da):67,202
Last modified:January 23, 2007 - v3
Checksum:i711A02C1E2DC9E77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014184 Genomic DNA. Translation: AAO44703.1.
RefSeqiNP_787734.1. NC_004572.3.

Genome annotation databases

EnsemblBacteriaiAAO44703; AAO44703; TWT_606.
GeneIDi1482595.
KEGGitwh:TWT606.
PATRICi23997831. VBITroWhi72342_0777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014184 Genomic DNA. Translation: AAO44703.1 .
RefSeqi NP_787734.1. NC_004572.3.

3D structure databases

ProteinModelPortali Q83FU2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 203267.TWT606.

Protein family/group databases

MEROPSi C44.971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO44703 ; AAO44703 ; TWT_606 .
GeneIDi 1482595.
KEGGi twh:TWT606.
PATRICi 23997831. VBITroWhi72342_0777.

Phylogenomic databases

eggNOGi COG0449.
KOi K00820.
OMAi CRIPCEV.
OrthoDBi EOG6KT2Q1.

Enzyme and pathway databases

BioCyci TWHI203267:GJDK-645-MONOMER.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00164. GlmS.
InterProi IPR017932. GATase_2_dom.
IPR000583. GATase_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF00310. GATase_2. 1 hit.
PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
    Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
    Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Twist.

Entry informationi

Entry nameiGLMS_TROWT
AccessioniPrimary (citable) accession number: Q83FU2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3