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Q83FU2

- GLMS_TROWT

UniProt

Q83FU2 - GLMS_TROWT

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Tropheryma whipplei (strain Twist) (Whipple's bacillus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei611 – 6111For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciTWHI203267:GJDK-645-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:TWT_606
    OrganismiTropheryma whipplei (strain Twist) (Whipple's bacillus)
    Taxonomic identifieri203267 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicrococcineaeTropheryma
    ProteomesiUP000002200: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 616615Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135407Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi203267.TWT606.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83FU2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 222221Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini289 – 428140SIS 1UniRule annotationAdd
    BLAST
    Domaini461 – 606146SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    KOiK00820.
    OMAiCRIPCEV.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q83FU2-1 [UniParc]FASTAAdd to Basket

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    MCGIIGYSGP RPAAEVLLKG LERLEYRGYD SAGIAVVTDK AYIESVKKSG    50
    KLNVLKTCLE RRTTPIVGST GIGHTRWATH GEPSDRNAHP HMDTEQSLAI 100
    VHNGIIENSD VLKRELLASG KSFTSETDTE VVAHLLSDAF KKTQDLVQAF 150
    VEVTQRLEGA FAVVAIHKDQ PNTIVAAKNN SPLLLGFGQG ENFLASDIAA 200
    FAEYTQRVAN IDQERIVALS GDSVYITDFA GHPVDYEVHT VSWHPASVDS 250
    SGWSSFMLKE IFEEPQAVEN TLKGRTEDGT VILPECDHIR DDLLAIDRVV 300
    LVGCGTAAYA AMTASYSIEA WAGLPVSVEL SHEFRYREPV LNSKTLAVFI 350
    SQSGETMDSL MAVRYARQAG VKTISVCNVM DSSIPKESHA VIYTKAGPEV 400
    AVASTKSFVC QIVVLYLLAL YLGQLRGFRS IFPRQKAVCE LNRLPVKLKQ 450
    VLEIYESVRQ LAHWMSDSRS ILFLGRHAGY PIALEAALKL KELAYIHAEG 500
    FAAGELKHGP IALIEPGQPV FVIVPSPVGS PILHAKVISN IREIKSRGAR 550
    IIAIAAEGDS AVLPHTDSVL RIPLTRYSFE PLLSIVPLQI FALELAADKG 600
    FDVDRPRNLA KSVTVE 616
    Length:616
    Mass (Da):67,202
    Last modified:January 23, 2007 - v3
    Checksum:i711A02C1E2DC9E77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014184 Genomic DNA. Translation: AAO44703.1.
    RefSeqiNP_787734.1. NC_004572.3.
    WP_011102677.1. NC_004572.3.

    Genome annotation databases

    EnsemblBacteriaiAAO44703; AAO44703; TWT_606.
    GeneIDi1482595.
    KEGGitwh:TWT606.
    PATRICi23997831. VBITroWhi72342_0777.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014184 Genomic DNA. Translation: AAO44703.1 .
    RefSeqi NP_787734.1. NC_004572.3.
    WP_011102677.1. NC_004572.3.

    3D structure databases

    ProteinModelPortali Q83FU2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 203267.TWT606.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO44703 ; AAO44703 ; TWT_606 .
    GeneIDi 1482595.
    KEGGi twh:TWT606.
    PATRICi 23997831. VBITroWhi72342_0777.

    Phylogenomic databases

    eggNOGi COG0449.
    KOi K00820.
    OMAi CRIPCEV.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci TWHI203267:GJDK-645-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
      Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
      Genome Res. 13:1800-1809(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Twist.

    Entry informationi

    Entry nameiGLMS_TROWT
    AccessioniPrimary (citable) accession number: Q83FU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3