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Q83FJ0 (DCUP_TROWT) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:TWT_735
OrganismTropheryma whipplei (strain Twist) (Whipple's bacillus) [Complete proteome] [HAMAP]
Taxonomic identifier203267 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micrococcineae › Tropheryma

Protein attributes

Sequence length385 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm Probable HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 385385Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000187655

Regions

Region53 – 575Substrate binding By similarity

Sites

Binding site1021Substrate By similarity
Binding site1791Substrate By similarity
Binding site2341Substrate By similarity
Binding site3631Substrate By similarity
Site1021Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q83FJ0 [UniParc].

Last modified June 1, 2003. Version 1.
Checksum: ED8BF414ABD35C5F

FASTA38541,233
        10         20         30         40         50         60 
MTGASGVEGT RIPLHSLSCR PSAGRSAGSF VNTGIMEAFR GTRPGCLPVW FMRQAGRSLP 

        70         80         90        100        110        120 
EYRAVRGTNT LLEACLNPDL ACEITLQPVR RYSVDAAILF SDIVVPLKLA GVGVDILPGT 

       130        140        150        160        170        180 
GPVLNNPIDT PDRVNTLLAK TADSIDFGII AEITRHTVSV LNGIPLIGFA GAPYTLACYM 

       190        200        210        220        230        240 
VEGGPSKTHM KARAMMHGDK KTWQKVMMLA ARLSGQFLAA QITSGAQAVQ IFDSWAGSLS 

       250        260        270        280        290        300 
RKDYVDNVAP FSKMTIDLAC GIDGNSDLSK TGKSLWPRVP VLHFAANAGH LLTAIRDIGV 

       310        320        330        340        350        360 
SVMSVDYTKP LDEASELLDD SMPLQGNIDP AMLFAPWEVL KRHVLDIVQR ASRAPSHVLN 

       370        380 
LGHGVPPDAS CDQLARIVDL AHSMV

« Hide

References

[1]"Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome."
Raoult D., Ogata H., Audic S., Robert C., Suhre K., Drancourt M., Claverie J.-M.
Genome Res. 13:1800-1809(2003) [PubMed: 12902375] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Twist.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE014184 Genomic DNA. Translation: AAO44832.1.
RefSeqNP_787863.1. NC_004572.3.

3D structure databases

ProteinModelPortalQ83FJ0.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ83FJ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1482180.
GenomeReviewsGene locus TWT_735 in contig AE014184_GR.
KEGGtwh:TWT735.
PATRIC23998133. VBITroWhi72342_0918.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0407.
HOGENOMHBG628392.
OMAPRIHFGV.
PhylomeDBQ83FJ0.
ProtClustDBCLSK230257.

Enzyme and pathway databases

BioCycTWHI203267:TW735-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_TROWT
AccessionPrimary (citable) accession number: Q83FJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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