Q83FD8 (DNAA_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	CBU_0001

Organism

Coxiella burnetii

Taxonomic identifier

777 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella

Protein attributes

Sequence length	451 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 451	451	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_0000114170
Regions
	Nucleotide binding	156 – 163	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q83FD8 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: 4615CFBF16DE0C5E	FASTA	451	51,096
	10 20 30 40 50 60 MSLPTSLWDK CLGYLRDEIP PQQYNTWIRP LHAIESKQNG LLLLAPNRFV LDWINERFLN 70 80 90 100 110 120 RITELLDELS DTPPQIRLQI GSRSTEMPTK NSHEPSHRKA AAPPAGTTIS HTQANINSNF 130 140 150 160 170 180 TFDSFVEGKS NQLARAAATQ VAENPGQAYN PLFIYGGVGL GKTHLMHAVG NAILRKDSSK 190 200 210 220 230 240 KVLYLHSERF VADMIKALQH NAMNEFKRFY RSLNALLIDD IQFFAGKDRS QEEFFHTFNA 250 260 270 280 290 300 LLDGQQQIIL TCDRYPKEIN GLEERLQSRF GWGLTVAIEP PELETRVAIL MSKAEQLKVH 310 320 330 340 350 360 LPHEVAFFIA KHIQSNVREL EGALKRVIAN AHFTGQSITV DFTREALKDL LTLQARLITI 370 380 390 400 410 420 ENIQKTVAEY YKIKVADLLA KRRNRSVARP RQMAMALAKE LTNHSLPEIG DAFGGRDHTT 430 440 450 VLHACRKVKE LLATSLDILE DYKNLMRILS G

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO89571.1.
RefSeq	NP_819057.1. NC_002971.3.
3D structure databases
ProteinModelPortal	Q83FD8.
SMR	Q83FD8. Positions 358-450.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1207921.
GenomeReviews	Gene locus CBU_0001 in contig AE016828_GR.
KEGG	cbu:CBU_0001.
NMPDR	fig|227377.1.peg.1.
PATRIC	17928679. VBICoxBur82552_0002.
TIGR	CBU_0001.
Phylogenomic databases
HOGENOM	HBG695666.
OMA	CHTLNAL.
PhylomeDB	Q83FD8.
ProtClustDB	PRK00149.
Enzyme and pathway databases
BioCyc	CBUR227377:CBU_0001-MONOMER.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_COXBU

Accession

Primary (citable) accession number: Q83FD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	June 1, 2003
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program