Q83FD0 (AROE_COXBU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase
EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	CBU_0010

Organism

Coxiella burnetii (strain RSA 493 / Nine Mile phase I) [Reference proteome] [HAMAP]

Taxonomic identifier

227377 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella › Coxiella burnetii

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP-Rule MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP-Rule MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP chorismate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway shikimate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Shikimate dehydrogenase HAMAP-Rule MF_00222		PRO_1000021279
Regions
	Nucleotide binding	127 – 131	5	NADP By similarity
Sites
	Active site	65	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q83FD0 [UniParc]. Last modified June 1, 2003. Version 1. Checksum: F1DA0DAB51DADB73	FASTA	272	29,794
	10 20 30 40 50 60 MDKYAVIGNP VEHSLSPVIF QAFEKQTNHS FDYLKIKAPV NGFAAAVKKF HDEGGKGANI 70 80 90 100 110 120 TLPFKEEAYQ LADKRSQEAN EAHVASALQF REDGTIYAVN YDGLGLVQDL TRNHNITLTQ 130 140 150 160 170 180 KSILIVGAGG ATRGILGPLL NAAPEKIVIV NRTPSKAHAL AKIFHLRGEI QGGGFDELEP 190 200 210 220 230 240 MRYDVIIHAT SLGHQGKFPP LPDGLIGSQS CCYDLSYGKI ASPFLQWAKD QGAKYNFDGL 250 260 270 GMLVEHNAAV FYLWFGIYPD TNPVIEMLQA HL

References

[1]

"Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. , Scanlan D., Heinzen R.A., Thompson H.A., Samuel J.E., Fraser C.M., Heidelberg J.F. Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RSA 493 / Nine Mile phase I.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE016828 Genomic DNA. Translation: AAO89580.1.
RefSeq	NP_819066.1. NC_002971.3.
3D structure databases
ProteinModelPortal	Q83FD0.
ModBase	Search...
Protein-protein interaction databases
STRING	227377.CBU_0010.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAO89580; AAO89580; CBU_0010.
GeneID	1207872.
KEGG	cbu:CBU_0010.
PATRIC	17928699. VBICoxBur82552_0012.
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HOG000237876.
KO	K00014.
OMA	AFDLIIN.
ProtClustDB	CLSK913771.
Enzyme and pathway databases
BioCyc	CBUR227377:GJ7S-13-MONOMER.
UniPathway	UPA00053; UER00087.
Family and domain databases
Gene3D	3.40.50.720. 1 hit.
HAMAP	MF_00222. Shikimate_DH_AroE.
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_COXBU

Accession

Primary (citable) accession number: Q83FD0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 1, 2003
Last modified:	May 29, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program