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Q83FD0

- AROE_COXBU

UniProt

Q83FD0 - AROE_COXBU

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Protein

Shikimate dehydrogenase

Gene
aroE, CBU_0010
Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Shikimate + NADP+ = 3-dehydroshikimate + NADPH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei65 – 651Proton acceptor Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi127 – 1315NADP By similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. shikimate 3-dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
  3. shikimate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciCBUR227377:GJ7S-13-MONOMER.
UniPathwayiUPA00053; UER00087.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate dehydrogenase (EC:1.1.1.25)
Gene namesi
Name:aroE
Ordered Locus Names:CBU_0010
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
ProteomesiUP000002671: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Shikimate dehydrogenaseUniRule annotationPRO_1000021279Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi227377.CBU_0010.

Structurei

3D structure databases

ProteinModelPortaliQ83FD0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0169.
HOGENOMiHOG000237876.
KOiK00014.
OMAiPFKEDAY.
OrthoDBiEOG6RRKMV.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00222. Shikimate_DH_AroE.
InterProiIPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view]
PfamiPF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00507. aroE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q83FD0-1 [UniParc]FASTAAdd to Basket

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MDKYAVIGNP VEHSLSPVIF QAFEKQTNHS FDYLKIKAPV NGFAAAVKKF    50
HDEGGKGANI TLPFKEEAYQ LADKRSQEAN EAHVASALQF REDGTIYAVN 100
YDGLGLVQDL TRNHNITLTQ KSILIVGAGG ATRGILGPLL NAAPEKIVIV 150
NRTPSKAHAL AKIFHLRGEI QGGGFDELEP MRYDVIIHAT SLGHQGKFPP 200
LPDGLIGSQS CCYDLSYGKI ASPFLQWAKD QGAKYNFDGL GMLVEHNAAV 250
FYLWFGIYPD TNPVIEMLQA HL 272
Length:272
Mass (Da):29,794
Last modified:June 1, 2003 - v1
Checksum:iF1DA0DAB51DADB73
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO89580.1.
RefSeqiNP_819066.1. NC_002971.3.

Genome annotation databases

EnsemblBacteriaiAAO89580; AAO89580; CBU_0010.
GeneIDi1207872.
KEGGicbu:CBU_0010.
PATRICi17928699. VBICoxBur82552_0012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE016828 Genomic DNA. Translation: AAO89580.1 .
RefSeqi NP_819066.1. NC_002971.3.

3D structure databases

ProteinModelPortali Q83FD0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 227377.CBU_0010.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAO89580 ; AAO89580 ; CBU_0010 .
GeneIDi 1207872.
KEGGi cbu:CBU_0010.
PATRICi 17928699. VBICoxBur82552_0012.

Phylogenomic databases

eggNOGi COG0169.
HOGENOMi HOG000237876.
KOi K00014.
OMAi PFKEDAY.
OrthoDBi EOG6RRKMV.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00087 .
BioCyci CBUR227377:GJ7S-13-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00222. Shikimate_DH_AroE.
InterProi IPR016040. NAD(P)-bd_dom.
IPR011342. Shikimate_DH.
IPR013708. Shikimate_DH-bd_N.
IPR022893. Shikimate_quinate_DH.
IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
[Graphical view ]
Pfami PF01488. Shikimate_DH. 1 hit.
PF08501. Shikimate_dh_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00507. aroE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RSA 493 / Nine Mile phase I.

Entry informationi

Entry nameiAROE_COXBU
AccessioniPrimary (citable) accession number: Q83FD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2003
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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