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Q83FD0

- AROE_COXBU

UniProt

Q83FD0 - AROE_COXBU

Protein

Shikimate dehydrogenase

Gene

aroE

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Jun 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Shikimate + NADP+ = 3-dehydroshikimate + NADPH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei65 – 651Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi127 – 1315NADPUniRule annotation

    GO - Molecular functioni

    1. NADP binding Source: InterPro
    2. shikimate 3-dehydrogenase (NADP+) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway
    3. shikimate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciCBUR227377:GJ7S-13-MONOMER.
    UniPathwayiUPA00053; UER00087.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Shikimate dehydrogenaseUniRule annotation (EC:1.1.1.25UniRule annotation)
    Gene namesi
    Name:aroEUniRule annotation
    Ordered Locus Names:CBU_0010
    OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
    Taxonomic identifieri227377 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
    ProteomesiUP000002671: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 272272Shikimate dehydrogenasePRO_1000021279Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi227377.CBU_0010.

    Structurei

    3D structure databases

    ProteinModelPortaliQ83FD0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the shikimate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0169.
    HOGENOMiHOG000237876.
    KOiK00014.
    OMAiPFKEDAY.
    OrthoDBiEOG6RRKMV.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00222. Shikimate_DH_AroE.
    InterProiIPR016040. NAD(P)-bd_dom.
    IPR011342. Shikimate_DH.
    IPR013708. Shikimate_DH-bd_N.
    IPR022893. Shikimate_quinate_DH.
    IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
    [Graphical view]
    PfamiPF01488. Shikimate_DH. 1 hit.
    PF08501. Shikimate_dh_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00507. aroE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q83FD0-1 [UniParc]FASTAAdd to Basket

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    MDKYAVIGNP VEHSLSPVIF QAFEKQTNHS FDYLKIKAPV NGFAAAVKKF    50
    HDEGGKGANI TLPFKEEAYQ LADKRSQEAN EAHVASALQF REDGTIYAVN 100
    YDGLGLVQDL TRNHNITLTQ KSILIVGAGG ATRGILGPLL NAAPEKIVIV 150
    NRTPSKAHAL AKIFHLRGEI QGGGFDELEP MRYDVIIHAT SLGHQGKFPP 200
    LPDGLIGSQS CCYDLSYGKI ASPFLQWAKD QGAKYNFDGL GMLVEHNAAV 250
    FYLWFGIYPD TNPVIEMLQA HL 272
    Length:272
    Mass (Da):29,794
    Last modified:June 1, 2003 - v1
    Checksum:iF1DA0DAB51DADB73
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO89580.1.
    RefSeqiNP_819066.1. NC_002971.3.

    Genome annotation databases

    EnsemblBacteriaiAAO89580; AAO89580; CBU_0010.
    GeneIDi1207872.
    KEGGicbu:CBU_0010.
    PATRICi17928699. VBICoxBur82552_0012.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE016828 Genomic DNA. Translation: AAO89580.1 .
    RefSeqi NP_819066.1. NC_002971.3.

    3D structure databases

    ProteinModelPortali Q83FD0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 227377.CBU_0010.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAO89580 ; AAO89580 ; CBU_0010 .
    GeneIDi 1207872.
    KEGGi cbu:CBU_0010.
    PATRICi 17928699. VBICoxBur82552_0012.

    Phylogenomic databases

    eggNOGi COG0169.
    HOGENOMi HOG000237876.
    KOi K00014.
    OMAi PFKEDAY.
    OrthoDBi EOG6RRKMV.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00087 .
    BioCyci CBUR227377:GJ7S-13-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00222. Shikimate_DH_AroE.
    InterProi IPR016040. NAD(P)-bd_dom.
    IPR011342. Shikimate_DH.
    IPR013708. Shikimate_DH-bd_N.
    IPR022893. Shikimate_quinate_DH.
    IPR006151. Shikm_DH/Glu-tRNA_Rdtase.
    [Graphical view ]
    Pfami PF01488. Shikimate_DH. 1 hit.
    PF08501. Shikimate_dh_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00507. aroE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RSA 493 / Nine Mile phase I.

    Entry informationi

    Entry nameiAROE_COXBU
    AccessioniPrimary (citable) accession number: Q83FD0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Coxiella burnetii
      Coxiella burnetii (strain RSA 493): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3