Reviewed,
UniProtKB/Swiss-Prot Q83FD0 (AROE_COXBU)
Last modified
June 16, 2009.
Version 44.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Shikimate dehydrogenase EC=1.1.1.25 | ||||
| Gene names |
| ||||
| Organism | Coxiella burnetii [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 777 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Coxiellaceae › Coxiella |
Protein attributes
| Sequence length | 272 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222 |
| Pathway | Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7. HAMAP MF_00222 |
| Sequence similarities | Belongs to the shikimate dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Aromatic amino acid biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: InterPro |
| Molecular function | NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 272 | 272 | Shikimate dehydrogenase HAMAP MF_00222 | PRO_1000021279 | |||||
Regions | |||||||||
| Nucleotide binding | 127 – 131 | 5 | NADP By similarity | ||||||
Sites | |||||||||
| Active site | 65 | 1 | Proton acceptor Potential | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Complete genome sequence of the Q-fever pathogen, Coxiella burnetii." Seshadri R., Paulsen I.T., Eisen J.A., Read T.D., Nelson K.E., Nelson W.C., Ward N.L., Tettelin H., Davidsen T.M., Beanan M.J., DeBoy R.T., Daugherty S.C., Brinkac L.M., Madupu R., Dodson R.J., Khouri H.M., Lee K.H., Carty H.A. Heidelberg J.F.Proc. Natl. Acad. Sci. U.S.A. 100:5455-5460(2003) [PubMed: 12704232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Nine Mile phase I / RSA 493. |
Cross-references
Sequence databases | |
|---|---|
| AE016828 Genomic DNA. Translation: AAO89580.1. | |
| RefSeq | NP_819066.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1NYT based on UniProtKB P15770. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1207872. |
| GenomeReviews | Gene locus CBU_0010 in contig AE016828_GR. |
| KEGG | cbu:CBU_0010. |
| NMPDR | fig|227377.1.peg.10. |
| TIGR | CBU_0010. |
Phylogenomic databases | |
| HOGENOM | Q83FD0. |
| OMA | Q83FD0. YDMMYGR. |
Enzyme and pathway databases | |
| BioCyc | CBUR227377:CBU_0010-MON. |
| BRENDA | 1.1.1.25. 256353. |
Family and domain databases | |
| HAMAP | MF_00222. [Tree] |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| Pfam | PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00507. aroE. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | AROE_COXBU | ||||||||
| Accession | Primary (citable) accession number: Q83FD0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Coxiella burnetii Coxiella burnetii (strain RSA 493): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


